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| 1 | Laboratory markers in ulcerative colitis: Current insights and future advances显示文摘Ulcerative colitis(UC)and Crohn’s disease(CD)are the major forms of inflammatory bowel diseases(IBD)in man.Despite some common features,these forms can be distinguished by different genetic predisposition,risk factors and clinical,endoscopic and histological characteristics.The aetiology of both CD and UC remains unknown,but several evidences suggest that CD and perhaps UC are due to an excessive immuneresponse directed against normal constituents of the intestinal bacterial flora.Tests sometimes invasive are routine for the diagnosis and care of patients with IBD.Diagnosis of UC is based on clinical symptoms combined with radiological and endoscopic investigations.The employment of non-invasive biomarkers is needed.These biomarkers have the potential to avoid invasive diagnostic tests that may result in discomfort and potential complications.The ability to determine the type,severity,prognosis and response to therapy of UC,using biomarkers has long been a goal of clinical researchers.We describe the biomarkers assessed in UC,with special reference to acute-phase proteins and serologic markers and thereafter,we describe the new biological markers and the biological markers could be developed in the future:(1)serum markers of acute phase response:The laboratory tests most used to measure the acute-phase proteins in clinical practice are the serum concentration of C-reactive protein and the erythrocyte sedimentation rate.Other biomarkers of inflammation in UC include platelet count,leukocyte count,and serum albumin and serum orosomucoid concentrations;(2)serologic markers/antibodies:In the last decades serological and immunologic biomarkers have been studied extensively in immunology and have been used in clinical practice to detect specific pathologies.In UC,the presence of these antibodies can aid as surrogate markers for the aberrant host immune response;and(3)future biomarkers:The development of biomarkers in UC will be very important in the future.The progress of molecular biology tools(microarrays,proteomics and nanotechnology)have revolutionised the field of the biomarker discovery.The advances in bioinformatics coupled with cross-disciplinary collaborations have greatly enhanced our ability to retrieve,characterize and analyse large amounts of data generated by the technological advances.The techniques available for biomarkers development are genomics(single nucleotide polymorphism genotyping,pharmacogenetics and gene expression analyses)and proteomics.In the future,the additionof new serological markers will add significant benefit.Correlating serologic markers with genotypes and clinical phenotypes should enhance our understanding of pathophysiology of UC. | Michele Cioffi Antonella De Rosa Rosalba Serao Ilaria Picone Maria Teresa Vietri | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，1： | 14 |
| 2 | Metabolomics characterization of colostrum in three sow breeds and its influences on piglets' survival and litter growth rates显示文摘Background: Colostrum is the first secretion produced by mammary glands during the hours immediately preceding and succeeding parturition. This secretion differs from milk and represents an essential vehicle of passive immunity,prebiotic compounds and growth factors involved in intestinal development. Most of the literature concerning colostrum composition refers mainly to human and cow; and little is known about pig colostrum metabolome and how it varies between pig breeds and different farrowing parity. Thus, the aim of the present research is to provide new information about pig colostrum composition and the associations between metabolites, the sows' breed and the survival and growth rates of their litters.Results: Colostrum samples were gathered from 58 parturitions of sows belonging to three different breeds chosen for their importance in Italian heavy pig production: 31 Large White, 15 Landrace and 12 Duroc respectively. The defatted and ultrafiltered colostrum samples were analysed using1 H–NMR spectroscopy. Principal Components Analysis(PCA) was assessed on the obtained spectra. In addition, using a Stepwise Regression and a Linear Regression analyses the metabolites named after the signals assignment were tested for their associations with piglets' performances.Twenty-five metabolites were identified, comprehending monosaccharides, disaccharides(such as lactose), organic acids(lactate, citrate, acetate and formate), nitrogenous organic acids(such as creatine) and other compounds,including nucleotides. PCA results evidence a clustering due to breed and season effects. Lactose was the main compound determining the assignment of the samples into different clusters according to the sow breed. Furthermore, some metabolites showed to be associated with piglets' performance and survival traits: acetate and taurine were positively related to litter weight gain and piglets' survival rate, respectively, while dimethylamine and cis-aconitate were linked to new-borns' impaired ability to survive.Conclusions: The results obtained suggest that colostrum composition is affected by breed, which, together with environmental conditions, may cause changes in colostrum metabolites content with possible consequences on piglets' performances. Among the identified metabolites, acetate, taurine, dimethylamine and cis-aconitate showed consistent associations with piglets' survival rate and litter weight gain, implying that these compounds may affect new-borns' ability to survive. | Gianfranco Picone Martina Zappaterra Diana Luise Alessia Trimigno Francesco Capozzi Vincenzo Motta Roberta Davoli Leonardo Nanni Costa Paolo Bosi Paolo Trevisi | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 6 |
| 3 | Magnetic resonance imaging of the cirrhotic liver in the eraof gadoxetic acid显示文摘Gadoxetic acid improves detection and characterization of focal liver lesions in cirrhotic patients and can estimate liver function in patients undergoing liver resection.The purpose of this article is to describe the optimal gadoxetic acid study protocol for the liver,the unique characteristics of gadoxetic acid,the differences between gadoxetic acid and extra-cellular gadolium chelates,and the differences in phases of enhancement between cirrhotic and normal liver using gadoxetic acid.We also discuss how to obtain and recognize an adequate hepatobiliary phase. | Francesco Agnello Marco Dioguardi Burgio Dario Picone Federica Vernuccio Giuseppe Cabibbo Lydia Giannitrapani Adele Taibbi Antonino Agrusa Tommaso Vincenzo Bartolotta Massimo Galia Roberto Lagalla Massimo Midiri Giuseppe Brancatelli | 2016 | World Journal of Gastroenterology2016，22，1： | 4 |
| 4 | Chronic liver failure-consortium acute-on-chronic liver failure and acute decompensation scores predict mortality in Brazilian cirrhotic patients显示文摘AIM To validate prognostic scores for acute decompensation of cirrhosis and acute-on-chronic liver failure in Brazilian patients.METHODS This is a prospective cohort study designed to assess the prognostic performance of the chronic liver failure-consortium(CLIF-C) acute decompensation score(CLIF-C AD) and CLIF-C acute-on-chronic liver failure score(CLIF-C ACLF),regarding 28-d and 90-d mortality,as well as to compare them to other prognostic models,such as Model for End-Stage Liver Disease(MELD),MELD Sodium(MELD-Na),ChildPugh(CP) score,and the CLIF-C Organ Failure score(CLIF-C OF). All participants were adults with acute decompensation of cirrhosis admitted to the Emergency Department of a tertiary hospital in southern Brazil. Prognostic performances were evaluated by means of the receiver operating characteristic(ROC) curves,area under the curves(AUC) and 95%CI.RESULTS One hundred and thirteen cirrhotic patients were included. At admission,18 patients had acute-onchronic liver failure(ACLF) and 95 individuals had acute decompensation(AD) without ACLF,of which 24 eventually developed ACLF during the course of hospitalization(AD evolving to ACLF group). The AD group had significantly lower 28-d(9.0%) and 90-d(18.3%) mortality as compared to the AD evolving to ACLF group and to the ACLF group(both P < 0.001). On the other hand,28-d and 90-d mortalities were not significantly different between AD evolving to ACLF group and ACLF group(P = 0.542 and P = 0.708,respectively). Among patients with ACLF,at 28 d from the diagnosis,CLIF-C ACLF was the only score able to predict mortality significantly better than the reference line,with an AUC(95%CI) of 0.71(95%CI: 0.54-0.88,P = 0.021). Among patients with AD,all prognostic scores performed significantly better than the reference line regarding 28-d mortality,presenting with similar AUCs: CLIF-C AD score 0.75(95%CI: 0.63-0.88),CP score 0.72(95%CI: 0.59-0.85),MELD score 0.75(95%CI: 0.61-0.90),MELD-Na score 0.76(95%CI: 0.61-0.90),and CLIF-C OF score 0.74(95%CI: 0.60-0.88). The same occurred concerning AUCs for 90-d mortality: CLIF-C AD score 0.70(95%CI: 0.57-0.82),CP score 0.73(95%CI: 0.62-0.84),MELD score 0.71(95%CI: 0.59-0.83),MELD-Na score 0.73(95%CI: 0.62-0.84),and CLIF-C OF score 0.65(95%CI: 0.52-0.78).CONCLUSION This study demonstrated that CLIF-C ACLF is the best available score for the prediction of 28-d mortality among patients with ACLF. CLIF-C AD score is also useful for the prediction of mortality among cirrhotic patients with AD not fulfilling diagnostic criteria for ACLF,but it was not superior to other well-established prognostic scores. | Rafael Veiga Picon Franciele Sabadin Bertol Cristiane Valle Tovo Angelo Zambam de Mattos | 2017 | World Journal of Gastroenterology2017，23，28： | 4 |
| 5 | Maintenance of Remission Among Patients With Crohn’s Disease on Antimetabolite Therapy After Infliximab Therapy Is Stopped显示文摘 | Edouard Louis Jean–Yves Mary Gwenola Vernier–Massouille Jean–Charles Grimaud Yoram Bouhnik David Laharie Jean–Louis Dupas Hélène Pillant Laurence Picon Michel Veyrac Mathurin Flamant Guillaume Savoye Raymond Jian Martine DeVos Rapha?l Porcher Gilles Paint | 2012 | Gastroenterology2012，，1： | 4 |
| 6 | A cluster-based power-efficient MAC protocol for event-driven sensing applications显示文摘 | LAZAROU G Y LI Jing PICONE J | 2007 | Ad hoc Networks2007，5，7： | 1 |
| 7 | Matrix metalloproteinase inhibitor prevents acute lung injury after cardiopulmonary bypass显示文摘 | Carney DE Lutz CJ Picone AL | 1999 | Circulation1999，100，4： | 1 |
| 8 | Multiple sequential insult cause post - pump syndrome显示文摘 | Picone AL Lutz CJ Finck C | 1999 | Ann Thorac Surg1999，67，： | 1 |
| 9 | Does hygiene counseling have an impact on the rate of CMV primary infection during pregnancy? Results of a 3-year prospective study in a French hospital 显示文摘 | Vauloup -Fellous C Picone O Cordier AG | 2009 | J Clin Virol2009，46，4： | 1 |
| 10 | Thermal integration of heat pumping systems in distillation columns 显示文摘 | P Rivera - Ortega M picon - Nunez E Tortes - reyes A Gallegos - Munoz | 1999 | Applied Thermal Engi- neering1999，19，81： | 1 |
| 11 | Community - onset bacteremia due to extended - spectrum beta -laetamase- producing Eseherichia coli:risk factors and progno- sis显示文摘 | WP MULTINATIONALA ROMANYAP O J PICON E GIJON P | 2010 | Clin Infect Dis2010，50，1： | 1 |
| 12 | Effect of morphine and naloxone on motor response of the human esophagus to swallowing and distension 显示文摘 | Picone A Bianchi PA | 1996 | Am J Physiol1996，271，41： | 1 |
| 13 | Chaoticity of a reverberation chamber assessed from the analysis of modal distributions obtained by FEM显示文摘 | Orjubin R Richalot E Picon O | 2007 | IEEE Trans on Electromagnetic Compatibility2007，49，4： | 1 |
| 14 | Cerebral metastases of a chorio- carcinoma during pregnancy 显示文摘 | Picone O Castaigne V Ede C | 2003 | Obstet Gyneco12003，102，： | 1 |
| 15 | 查看详情显示文摘 | Picone O de Keersmaecker B Ville Y | | 0，，： | 1 |
| 16 | Signal modeling techniques in speech recogni- tion显示文摘 | Picone J W | 1993 | Proceedings of the IEEE1993，81，9： | 1 |
| 17 | Matrix metalloprotein ase inhibitor prevents acute lung injury after cardiopulmonary bypass显示文摘 | Lutz CJ Picone AL | 1999 | Circulation1999，100，4： | 1 |
| 18 | Validation of Brazilian Portuguese version of quality of life questiomaire for women with endometriosis (Endometriosis Health Profile Questionnaire EHP-30)显示文摘 | Mengarda CV Passos EP Picon P | 2008 | Rev Bias Ginecol Obstet2008，30，8： | 1 |
| 19 | Aβ oligomers and fibrillar aggregates induce different apoptotic pathways in LAN5 neuroblastoma cell cultures显示文摘 | Picone P Carrotta R Montana G | 2009 | Biophys J2009，96，10： | 1 |
| 20 | Multicenter validation of a reproducibleflow cytometric score for the diagnosis of low-grademyelodysplastic syndromes:results of a EuropeanLeukemia NET study显示文摘 | DELLA PORTA MG PICONE C PASCUTTOC | 2012 | Haematologica2012，97，8： | 1 |
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