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| 1 | On the combined effect of soil fertility and topography on tree growth in subtropical forest ecosystems—a study from SE China显示文摘Aims The aim of our research was to understand small-scale effects of topography and soil fertility on tree growth in a forest biodiversity and ecosystem functioning(BEF)experiment in subtropical SE China.Methods Geomorphometric terrain analyses were carried out at a spatial resolution of 5×5 m.Soil samples of different depth increments and data on tree height were collected from a total of 566 plots(667 m2 each).The soils were analyzed for carbon(soil organic carbon[SOC]),nitrogen,acidity,cation exchange capacity(CEC),exchangeable cations and base saturation as soil fertility attributes.All plots were classified into geomorphological units.Analyses of variance and linear regressions were applied to all terrain,soil fertility and tree growth attributes.Important Findings In general,young and shallow soils and relatively small differences in stable soil properties suggest that soil erosion has truncated the soils to a large extent over the whole area of the experiment.This explains the concurrently increasing CEC and SOC stocks downslope,in hollows and in valleys.However,colluvial,carbon-rich sediments are missing widely due to the convexity of the footslopes caused by uplift and removal of eroded sediments by adjacent waterways.The results showed that soil fertility is mainly influenced by topography.Monte-Carlo flow accumulation(MCCA),curvature,slope and aspect significantly affected soil fertility.Furthermore,soil fertility was affected by the different geomorphological positions on the experimental sites with ridge and spur positions showing lower exchangeable base cation contents,especially potassium(K),due to leaching.This geomorphological effect of soil fertility is most pronounced in the topsoil and decreases when considering the subsoil down to 50 cm depth.Few soil fertility attributes affect tree height after 1-2 years of growth,among which C stocks proved to be most important while pH_(KCl)and CEC only played minor roles.Nevertheless,soil acidity and a high proportion of Al on the exchange complex affected tree height even after only 1-2 years growth.Hence,our study showed that forest nutrition is coupled to a recycling of litter nutrients,and does not only depend on subsequent supply of nutrients from the mineral soil.Besides soil fertility,topography affected tree height.We found that especially MCCA as indicator of water availability affected tree growth at small-scale,as well as aspect.Overall,our synthesis on the interrelation between fertility,topography and tree growth in a subtropical forest ecosystem in SE China showed that topographic heterogeneity lead to ecological gradients across geomorphological positions.In this respect,small-scale soil-plant interactions in a young forest can serve as a driver for the future development of vegetation and biodiversity control on soil fertility.In addition,it shows that terrain attributes should be accounted for in ecological research. | Thomas Scholten Philipp Goebes Peter Kühn Steffen Seitz Thorsten Assmann Jürgen Bauhus Helge Bruelheide Francois Buscot Alexandra Erfmeier Markus Fischer Werner Härdtle Jin-Sheng He Keping Ma Pascal A.Niklaus Michael Scherer-Lorenzen Bernhard Schmid Xuezheng Shi Zhengshan Song Goddert von Oheimb Christian Wirth Tesfaye Wubet Karsten Schmidt | 2017 | Journal of Plant Ecology2017，10，1： | 22 |
| 2 | How Could Agricultural Land Systems Contribute to Raise Food Production Under Global Change?显示文摘To feed the increasing world population,more food needs to be produced from agricultural land systems.Solutions to produce more food with fewer resources while minimizing adverse environmental and ecological consequences require sustainable agricultural land use practices as supplementary to advanced biotechnology and agronomy.This review paper,from a land system perspective,systematically proposed and analyzed three interactive strategies that could possibly raise future food production under global change.By reviewing the current literatures,we suggest that cropland expansion is less possible amid fierce land competition,and it is likely to do less in increasing food production.Moreover,properly allocating crops in space and time is a practical way to ensure food production.Climate change,dietary shifts,and other socio-economic drivers,which would shape the demand and supply side of food systems,should be taken into consideration during the decision-making on rational land management in respect of sustainable crop choice and allocation.And finally,crop-specific agricultural intensification would play a bigger role in raising future food production either by increasing the yield per unit area of individual crops or by increasing the number of crops sown on a particular area of land.Yet,only when it is done sustainably is this a much more effective strategy to maximize food production by closing yield and harvest gaps. | WU Wen-bin YU Qiang-yi Verburg H Peter YOU Liang-zhi YANG Peng TANG Hua-jun | 2014 | Journal of Integrative Agriculture2014，13，7： | 19 |
| 3 | VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab显示文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab. | Markus Moehler Christian Frings Annett Mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann | 2008 | World Journal of Gastroenterology2008，14，26： | 15 |
| 4 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 5 | Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?显示文摘Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of death in critically ill patients. It is the most common condition with high mortality in intensive care units. The complexity of the septic syndrome comprises immunological aspects- i.e.,sepsis induced immunosuppression- but is not restricted to this fact in modern concepts. So far, exact mechanisms and variables determining outcome and mortality stay unclear. Since there is no typical risk profile, early diagnosis and risk stratification remain difficult, which hinders rapid and effective treatment initiation. Due to the heterogeneous nature of sepsis, potential therapy options should be adapted to the individual. Biomarkers like C-reactive protein and procalcitonin are routinely used as complementary tools in clinical decision-making. Beyond the acute phase proteins, a wide bunch of promising substances and non-laboratory tools with potential diagnostic and prognostic value is under intensive investigation. So far, clinical decision just based on biomarker assessment is not yet feasible. However, biomarkers should be considered as a complementary approach. | Dubravka Kojic Benedikt H Siegler Florian Uhle Christoph Lichtenstern Peter P Nawroth Markus A Weigand Stefan Hofer Thorsten Brenner | 2015 | World Journal of Experimental Medicine2015，5，2： | 14 |
| 6 | Spatio-Temporal Changes in the Rice Planting Area and Their Relationship to Climate Change in Northeast China: A Model-Based Analysis显示文摘Rice is one of the most important grain crops in Northeast China(NEC)and its cultivation is sensitive to climate change.This study aimed to explore the spatio-temporal changes in the NEC rice planting area over the period of 1980-2010 and to analyze their relationship to climate change.To do so,the CLUE-S(conversion of land use and its effects at small region extent)model was first updated and used to simulate dynamic changes in the rice planting area in NEC to understand spatio-temporal change trends during three periods:1980-1990,1990-2000 and 2000-2010.The changing results in individual periods were then linked to climatic variables to investigate the climatic drivers of these changes.Results showed that the NEC rice planting area expanded quickly and increased by nearly 4.5 times during 1980-2010.The concentration of newly planted rice areas in NEC constantly moved northward and the changes were strongly dependent on latitude.This confirmed that climate change,increases in temperature in particular,greatly influenced the shift in the rice planting area.The shift in the north limit of the NEC rice planting area generally followed a 1°C isoline migration pattern,but with an obvious time-lag effect.These findings can help policy makers and crop producers take proper adaptation measures even when exposed to the global warming situation in NEC. | XIA Tian WU Wen-bin ZHOU Qing-bo YU Qiang-yi Peter H Verburg YANG Peng LU Zhong-jun TANG Hua-jun | 2014 | Journal of Integrative Agriculture2014，13，7： | 12 |
| 7 | Post-transcriptional regulation of vascular endothelial growth factor: Implications for tumor angiogenesis显示文摘脉管的内皮生长因素(VEGF ) 是一个有势力为批评的分泌 mitogen 生理并且肿瘤血管生成。VEGF 的规定发生在几个层次,包括抄写, mRNA 稳定,翻译,和各种各样的 isoforms 的微分细胞的本地化。在我们 VEGF 的 post-transcriptional 规定的理解的最近的进展在 VEGF mRNA 的 5'UTR 包括内部 ribosomal 入口地点的稳定的 mRNA 绑定蛋白质,投,和发现的鉴定。Monoclonal anti-VEGF 抗体最近在人为使用被同意,但是为高全身的剂量受不了需要。RNA 干扰(RNAi ) 技术正在被使用在试管内并且在有有希望的结果的动物模型。这里,我们在 VEGF 的 post-transcriptional 规定上考察文学并且在为治疗学的利益指向这些机制描述最近的进步。 | Peter S Yoo Abby L Mulkeen Charles H Cha | 2006 | World Journal of Gastroenterology2006，12，31： | 11 |
| 8 | Bonfils纤维气管镜用于难以预料的困难气管插管的研究(英文)显示文摘目的 难以预料和失败的困难气管插管是引起麻醉并发症和麻醉病死率的重要因素。本研究探讨Bon fils纤维气管镜用于处理难以预料的困难气管插管的价值。方法 2 1例行体外循环下冠状动脉搭桥术的患者 ,经一名高年资的麻醉医生使用普通咽喉镜两次插管失败后作为研究对象。测定Bonfils纤维气管镜插管的成功率和插管时间 ,同时测定判断困难气管插管的临床指标 :甲颏距离、Mal lampti分类、张口度、寰枕关节的活动度等。结果 除外一个患者第二次插管成功外 ,第一次插管的成功率是 95 %。平均插管时间 (5 0± 2 5 )秒。 | 严敏 Peter H Tonner Jens Scholz Berthold Bein | 2004 | 中华急诊医学杂志2004，13，3： | 8 |
| 9 | Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart显示文摘出生后的心通过 hypertrophic 生长适应应力和超载,可能病理学或有益的一个过程(生理的肥大) 。生理的肥大改进心脏的性能在健康并且 diseased 个人,然而,宣传这有利改编的机制仍然保持糟糕定义。我们识别 cytokine cardiotrophin (CT1 ) 1 作为能够包括导致的导出 cardiomyocyte 的 angiogenic 信号的心肌层,和刺激的短暂、可逆的肥大概括心的生理的生长的特色的一个因素增加了由脉管形成。CT1 的能力从 caspase 激活的调停 CK2 的制止发源导致生理的肥大,阻止到无限制的病理学的生长的转变。外长的 CT1 蛋白质交货稀释了病理并且在正确的心失败的一个严格的模型恢复了可收缩的功能,建议为这难处理的心脏病的一种新奇处理选择。 | Mohammad Abdul-Ghani Colin Suen Baohua Jiang Yupu Deng Jonathan J Weldrick Charis Putinski Steve Brunette Pasan Femando Tom T Lee Peter Flynn Frans H H Leenen Patrick G Burgon Duncan J Stewar Lynn A Megeney | 2017 | Cell Research2017，27，10： | 8 |
| 10 | Interpretation of Climate Change and Agricultural Adaptations by Local Household Farmers: a Case Study at Bin County, Northeast China显示文摘Although climate change impacts and agricultural adaptations have been studied extensively,how smallholder farmers perceive climate change and adapt their agricultural activities is poorly understood.Survey-based data(presents farmers’personal perceptions and adaptations to climate change)associated with external biophysical-socioeconomic data(presents real-world climate change)were used to develop a farmer-centered framework to explore climate change impacts and agricultural adaptations at a local level.A case study at Bin County(1980s-2010s),Northeast China,suggested that increased annual average temperature(0.6°C per decade)and decreased annual precipitation(46 mm per decade,both from meteorological datasets)were correctly perceived by 76 and 66.9%,respectively,of farmers from the survey,and that a longer growing season was confirmed by 70%of them.These reasonably correct perceptions enabled local farmers to make appropriate adaptations to cope with climate change:Longer season alternative varieties were found for maize and rice,which led to a significant yield increase for both crops.The longer season also affected crop choice:More farmers selected maize instead of soybean,as implicated from survey results by a large increase in the maize growing area.Comparing warming-related factors,we found that precipitation and agricultural disasters were the least likely causes for farmers’agricultural decisions.As a result,crop and variety selection,rather than disaster prevention and infrastructure improvement,was the most common ways for farmers to adapt to the notable warming trend in the study region. | YU Qiang-yi WU Wen-bin LIU Zhen-huan Peter H Verburg XIA Tian YANG Peng LU Zhong-jun YOU Liang-zhi TANG Hua-jun | 2014 | Journal of Integrative Agriculture2014，13，7： | 8 |
| 11 | 氮与自然显示文摘在某种程度上,人类对全球氮循环的改变是很重要的,因为增加的氮极大地改变了许多天然生态系统的组成、生产率和其它性质。增加的氮为什么有这么大的影响力?为什么如此多的天然生态系统都处于缺氮状态?减缓氮相对于其它元素的循环过程,和控制生态系统水平的氮输入输出过程,都使氮供应成为生态系统动态的限制因子。我们讨论了可以减慢氮循环的因子陆地植物和其它有机体之间的化学计量学差异,蛋白质沉淀防御植物的多度,土壤有机质中C-N键状态。对输入来讲,氮固定的能量消耗及其后果,氮以外的养分供应,对固氮者的优先取食,所有这些都能限制生物固氮者的多度和/或活动。这些过程加在一起,推动和维持着许多天然陆地生态系统的氮限制。 | Peter M.Vitousek Stephan Htttenschwiler Lydia Olander Steven Allison 王胜 | 2002 | AMBIO-人类环境杂志2002，31，2： | 7 |
| 12 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 13 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 14 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 15 | 在润滑管理和润滑技术领域中涉及摩擦学的经济和环境方面的一些看法显示文摘本文是国际摩擦学理事会主席HPeter Jost教授应我国摩擦学学会理事长张嗣伟教授的邀请,为我国纪念摩擦学40周年会议而撰写的一篇书面讲话,因时间延误,未能在大会上发表。现征得作者本人的同意,特译成中文,在本刊发表,以饷读者。 | H Peter Jost 严飞 | 2006 | 润滑与密封2006，31，9： | 5 |
| 16 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 17 | Steatosis and steatohepatitis in postmortem material from Northwestern Greece显示文摘AIM: To determine the prevalence of steatosis and steatohepatitis in a series of autopsies in Northwestern Greece. METHODS: Liver biopsy material from a total of 600 autopsies performed over a period of 2 years (2006-2008) to def ine the cause of death was subjected to histological examination. Patient demographic data were also collected. Tissue sections were stained with different dyes for the evaluation of liver architecture, degree of fibrosis and other pathological conditions when necessary. RESULTS: Satisfactory tissue samples for histological evaluation were available in 498 cases (341 male, 157 female) with a mean age of 64.51 ± 17.78 years. In total, 144 (28.9%) had normal liver histology, 156 (31.3%) had evidence of steatosis, and 198 (39.8%) had typical histological findings of steatohepatitis. The most common causes of death were ischemic heart disease with or without myocardial infarction (43.4%), and traffic accidents (13.4%). CONCLUSION: A high prevalence of steatosis and steatohepatitis was detected in postmortem biopsies from Northwestern Greece. Since both diseases can have serious clinical consequences, they should be considered as an important threat to the health of the general population in Greece. | Christos D Zois Gerasimos H Baltayiannis Anna Bekiari Anna Goussia Peter Karayiannis Michalis Doukas Demetrios Demopoulos Antigoni Mitsellou Theodoros Vougiouklakis Vasiliki Mitsi Epameinondas V Tsianos | 2010 | World Journal of Gastroenterology2010，16，31： | 4 |
| 18 | 近岸风力发电机及其电磁场对鱼类的影响显示文摘随着近岸风力发电场大规模的开发,应用各种技术的海底电缆的数量也不断增加。风力发电场使用不同类型的电缆,这些电缆或用于内涡轮传输,或用于变压器阵列传输,以及变压器向岸上传输。由于通过海底电缆的电流会产生电磁场,因此人们关注磁场对鱼类可能产生的影响。研究显示,有些鱼类对磁敏感,因为它们要利用地磁场进行定位。这就意味着,如果地磁场发生局部改变,鱼体的空间格局将受到影响。当某一地区存在长期固定的磁暴露时,还应在鱼类的生理方面加以考虑,尤其对于那些较少进行迁移的鱼。虽然已有研究显示磁场能够影响鱼类,但目前只有有限的证据证实风力发电机的水下电缆产生的电磁场对鱼类会有影响。对于波罗的海欧洲鳗鲡的研究显示,这种影响并不是很重要。本文中,我们对海上输电所用的海底电缆类型进行了综述,对其产生的磁场性质进行了描述,同时总结了磁场对鱼类的影响,并探讨了这种影响与近岸风力发电场所用电缆之间的关系。 | Marcus C.hman Peter Sigray Hkan Westerberg 张晓琴 | 2007 | AMBIO-人类环境杂志2007，36，B12： | 4 |
| 19 | 钨/低活化钢连接用Fe基非晶钎料显示文摘采用单辊急冷技术制备Fe(60)Mn(15)B(16.67)Si(6.33)Sn2非晶箔带,将其作为钎料对DEMO聚变示范堆偏滤器用钨与低活化钢进行了钎焊连接。结果表明:1220℃温度下保温15 min所获得的钎焊接头界面结合良好,无孔洞、裂纹等宏观缺陷,其焊缝组织由单相Fe基固溶体、混合相层(固溶体基体上分布着(Fe,Cr)3B与FeW2B2相)和FeW2B2基化合物层3部分构成;基于合金组元的扩散与交互作用,揭示了钎焊接头组织特征与相关形成机制。 | 刘天鸷 王英敏 魏明玉 羌建兵 Hussler Peter 王建豹 练友运 刘翔 | 2018 | 材料热处理学报2018，39，6： | 4 |
| 20 | Recommendations to quantify villous atrophy in video capsule endoscopy images of celiac disease patients显示文摘AIM To quantify the presence of villous atrophy in endoscopic images for improved automation.METHODS There are two main categories of quantitative descriptors helpful to detect villous atrophy:(1) Statistical and(2) Syntactic. Statistical descriptors measure the small intestinal substrate in endoscope-acquired images based on mathematical methods. Texture is the most commonly used statistical descriptor to quantify villous atrophy. Syntactic descriptors comprise a syntax, or set of rules, for analyzing and parsing the substrate into a set of objects with boundaries. The syntax is designed to identify and distinguish three-dimensional structures based on their shape.RESULTS The variance texture statistical descriptor is useful to describe the average variability in image gray level representing villous atrophy, but does not determine the range in variability and the spatial relationships between regions. Improved textural descriptors will incorporate these factors, so that areas with variability gradients and regions that are orientation dependent can be distinguished. The protrusion syntactic descriptor is useful to detect three-dimensional architectural components, but is limited to identifying objects of a certain shape. Improvement in this descriptor will require incorporating flexibility to the prototypical template, so that protrusions of any shape can be detected, measured, and distinguished.CONCLUSION Improved quantitative descriptors of villous atrophy are being developed, which will be useful in detecting subtle, varying patterns of villous atrophy in the small intestinal mucosa of suspected and known celiac disease patients. | Edward J Ciaccio Govind Bhagat Suzanne K Lewis Peter H Green | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，18： | 3 |
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