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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Early detection of kidney disease in community setting:the Kidney Early Evaluation Program显示文摘 | Bron WW Peters RM Ohmit SE | | 0，，01： | 1 |
| 3 | Early detection of kid- ney disease in community settings: The Kidney Early Evaluation Program(KEEP) 显示文摘 | Brown WW Peters RM Ohmit SE | 2003 | Am J Kidney Dis2003，42，1： | 1 |
| 4 | ICU incident reporting systems显示文摘 | Alber WW Peter P Laura M | 2002 | Journal of Critical Care2002，17，2： | 1 |
| 5 | Lactate-a signal coordinating cell and systemic function显示文摘 | Andrew P Adam LM Peter WW | 2005 | J Exp Biol2005，208，： | 1 |
| 6 | Controlled -release oxyeodone relieves neuropathie pain :a randomized controlled trial in painful diabetic neuropathy显示文摘 | C Peter NW Dwight M Judith WW | 2003 | Pain2003，105，： | 1 |
| 7 | Computational fluid dynamics and stent design显示文摘 | Andreas OF Peter WW James EM | 2002 | Art Org2002，26，： | 1 |
| 8 | Management of congenital nonpigmented iris cyst显示文摘 | Christopher CS Peter AN Matthew WW | 2006 | Ophthalmology2006，113，： | 1 |
| 9 | , the kidney early evaluation pmgram (KEEP) 显示文摘 | Brown WW Peters RM Ohmit SE et ah Eraly detection of kidney diesase in community settings | 2003 | An: J Kidney Dis2003，42，1： | 1 |
| 10 | Early detection of kidney disease in community settings:the kidney early evaluation program (KEEP)显示文摘 | Brown WW Peters RM Ohmit SE | 2003 | Am J Kidney Dis2003，42，： | 1 |
| 11 | Association of C - Reactive protein with carotid atherosclerosis in men and women : the framingham heart study显示文摘 | Thomas JW Byung - Ho N Peter WW | 2002 | Arterioscler Thromb Vasc Biol2002，22，10： | 1 |
| 12 | Early detection of kidney disease in community settings:the kidney early evaluation program(KEEP)显示文摘 | Brown WW Peters RM Ohmit SE | 2003 | Am J Kidney Dis2003，42，： | 1 |
| 13 | Distribution and partitioning of tracemetals (Cd,Cu,Ni,Pb,Zn) in Galveston Baywaters显示文摘 | Tang DG Kent WW Peter HS | 2002 | Marine Chemistry2002，78，5： | 1 |
| 14 | Early detection of kidney disease in community settings:the Kidney Early Evaluation Program (KEEP)显示文摘 | Brown WW Peters RM Ohmit SE | | 0，，01： | 1 |
| 15 | Egg viability and worker policing in honey bees显示文摘 | Christian WW Pirk Peter Neumann Randall Hepburn | 2004 | The National Academy of Sciences of the USA2004，101，23： | 1 |
| 16 | An abundant and ubiquitous homooligomeric ring-shaped ATPase particle related to the putative vesicle fusion proteins Sec18p and NSF显示文摘 | Peters JM Walsh MJ Franke WW | 1990 | EMBO J1990，9，6： | 1 |
| 17 | Colchicine in the treat- ment of pulmonary fibrosis 显示文摘 | Peter SG McDougall JC Douglas WW | 2013 | Chest2013，103，1： | 1 |
| 18 | An abundant and ubiquitous ho- mo-oligomeric ring-shaped ATPase particle related to the putative ves- icle fusion proteins SeclSp and NSF显示文摘 | Peters JM Walsh M J Franke WW | 1990 | EMBO J1990，9，6： | 1 |
| 19 | Controlled-release oxycodone relieves neuropathic pain:a randomized controlled trial painful diabetic neuropathy显示文摘 | Peter NW Dwight M Judith WW | 2003 | Pain2003，105，： | 1 |
| 20 | Early detection of kidney disease in community settings:the kidney early evaluation program(KEEP) 显示文摘 | Brown WW Peters RM Ohmit SE | 2003 | Am J Kidney Dis2003，42，： | 1 |
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