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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | PAX6 mutation in association with ptosis, cataract, iris hypoplasia, corneal opacification and diabetes: a new variant of familial aniridia? 显示文摘 | Peter NM Leyland M Mudhar HS | 2013 | Clin Experiment Ophthalmol2013，41，9： | 1 |
| 3 | Multiple window correlation Analysis of HRV power and respiratory frequency显示文摘 | Maria HS Peter J | | 0，，10： | 1 |
| 4 | Relapsing polychondritis显示文摘 | Peter PD Michet CJ Jr Luthra HS | 2004 | Curr Opin Rheumatol2004，16，1： | 1 |
| 5 | Clinicopathological factors relating malignant lymphoma with Sjogren's syndrome显示文摘 | Anaya JM Mcguff HS Peter M | 1996 | Semi Arthrit Rheumat1996，25，5： | 1 |
| 6 | DNA microarray analysis for human congenital heart disease显示文摘 | Sharma HS Peters TH Moorhouse MJ | 2006 | Cell Biochem Biophys2006，44，1： | 1 |
| 7 | Cellular biomechanics in the lung 显示文摘 | Christopher M Waters Peter HS | 2002 | Am J Physiol Lung Cell Mol Physiol2002，283，： | 1 |
| 8 | PCR-amplification of GC-rich regions:′slowdown PCR′显示文摘 | Frey UH Bachmann HS Peters J | 2008 | Nature Protocols2008，3，8： | 1 |
| 9 | Recovery of water maze performance in aged versus adult rats after brain injury with the impact acceleration model显示文摘 | Peter HM Kevin JS Richard HS | 2000 | J Neurotrauma2000，17，12： | 1 |
| 10 | DNA microarray analysis for human congenital heart disease显示文摘 | Peters TH Moorhouse MJ | 2006 | Cell Biochem Biophys2006，44，1： | 1 |
| 11 | Comparative urodynamics of appendiceal and ureteral Mitrofanoff conduits in children 显示文摘 | Watson HS Bauer SB Peters CA | 1995 | J Urol1995，154，： | 1 |
| 12 | Correlation of lamotrigine concentration between serum and saliva显示文摘 | Melody R Shellee AG Michael VM Peter HT Toufic AF Richard HS | 2003 | Pharmacotherapy2003，23，： | 1 |
| 13 | Prognostic utility of growth differentiation factor-15 in patients with chronicheart failure显示文摘 | Kempf T von HS Peter T | 2007 | J Am Coll Cardiol2007，50，11： | 1 |
| 14 | Distribution and partitioning of tracemetals (Cd,Cu,Ni,Pb,Zn) in Galveston Baywaters显示文摘 | Tang DG Kent WW Peter HS | 2002 | Marine Chemistry2002，78，5： | 1 |
| 15 | Effect of UV-B on Lipid Content of Three Antarctic Marine Phytoplankton显示文摘 | Jennifer HS Andrew DD Peter DN | 1998 | Phytochemistry1998，49，4： | 1 |
| 16 | Lipids of cultured Phaeocystis pouchetii : Signatures for food-web, biogeochemical and environmental studiea in Antarctica and the Southern ocean显示文摘 | Peter DN Jennifer HS Andrew D | 1991 | Phytochemistry1991，30，10： | 1 |
| 17 | Thrombocytopenia at baseline is a predictor of in hospital mortality in patients undergoing percutaneous coronary intervention显示文摘 | Christopher BO Joan I Peter HS | 2008 | Am HeartJ2008，156，1： | 1 |
| 18 | Anatomical differences in the psoas muscles in young black and white men显示文摘 | Patrick HS Peter M Henrik S | 1999 | J Anat1999，194，： | 1 |
| 19 | Age-specific questionnaires distinguish GERD symptom frequency and severity in infants and young children: development and initial validation 显示文摘 | Deal L Gold BD Gremse DA Winter HS Peters SB Fraga PD | 2005 | J Pediatr Gastroenterol Nutr2005，41，2： | 1 |
| 20 | PCR-amplification of GC-rich regions:'slowdown PCR显示文摘 | Frey UH Bachmann HS Peters J | | 0，，08： | 1 |
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