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19篇 您的检索式:作者名="Peter WC"
    题名 作者 年代 出处 被引量
1Inhibition of angiogenesis and HCT-116 xenograft tumor growth in mice by kallistatin显示文摘AIM: To investigate the inhibitory effect of kallistatin (KAL) on angiogenesis and HCT-116 xenograft tumor growth. METHODS: Heterotopic tumors were induced by subcutaneous injection of 2 × 106 HCT-11 cells in mice. Seven days later, 2 × 1011 rAAV-GFP or rAAV-KAL was injected intratumorally (n = 5 for each group). The mice were sacrificed at d 28, by which time the tumors in the rAAV-GFP group had grown to beyond 5% of the total body weight. Tumor growth was measured by calipers in two dimensions. Tumor angiogenesis was determined with tumor microvessel density (MVD) by immunohistology. Tumor cell proliferation was assessed by Ki-67 staining. RESULTS: Intratumor injection of rAAV-KAL inhibited tumor growth in the treatment group by 78% (171 ± 52 mm3) at d 21 after virus infection compared to the control group (776 ± 241 mm3). Microvessel density was significantly inhibited in tumor tissues treated with rAAV-KAL. rAAV-KAL also decreased the proportion of proliferating cells (Ki-67 positive cells) in tumors compared with the control group.CONCLUSION: rAAV-mediated expression of KAL inhibits the growth of colon cancer by reducing angiogenesis and proliferation of tumor cells, and may provide a promising anti-angiogenesis-based approach to the treatment of metastatic colorectal cancer.Yong Diao Jian Ma Wei-Dong Xiao Jia Luo Xin-Yan Li Kin-Wah Chu Peter WC Fung Nagy Habib Farzin Farzaneh Rui-An Xu 2007World Journal of Gastroenterology2007,13,34:15
2Tissue oxygenation andperfusion in patients with systemic sepsis显示文摘Sair M Etherington P Peter WC etal 2001Crit Care Med2001,29,7:1
3An extended trochanteric osteotomy for revision total hip replacement显示文摘Peters PC Head WC Emerson RH 1993J Bone Joint Surg1993,75,:1
4The structure of the glycolipid components of the aridicin antibiotic complex 显示文摘Peter WC George C Rorbert S 1985JOrg Chem1985,50,:1
5Lipoprotein (a) serum concentration and apolipoprotein(a) phenotype correlate with severity and presence of isehemic ccrebrovascular disease 显示文摘Jurgen G Taddei - Peters WC Koltringer P 1995Stroke1995,26,:1
6Gastrointestinal mucosal integrity after prolonged exercise with fluid supplementation显示文摘Peters HP Wiersma WC Akkermans LM 2000Med Sci Sports Exerc2000,32,1:1
7Severe asthma:an overview显示文摘Moore WC Peters SP 2006J Allergy Clin Immunol2006,117,3:1
8Effect of von Willebrand factor Y/C1584 on in vivo protein level and function and interaction with ABO blood group显示文摘James AD Peter WC Lee SH 2007Blood2007,109,7:1
9Acquired hemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors' Organisation 显示文摘Peter WC Sybil H Trevor PB 2007Blood2007,109,:1
10Severe asthma: An overview显示文摘Moore WC Peters SP 2006J Allergy Clin Immunol2006,117,3:1
11Alobar holoprosencephaly: ultrasonographic prenatal diagnosis显示文摘 Daryl HC Peter WC 1984Radiology1984,151,5:1
12Preliminary report: isolation of Ebola virus from monkeys imported to USA 显示文摘Jahrling PB Geisbert TW Dalgard DW Johnson ED Ksiazek TG Hall WC Peters CA 1990Lancet1990,335,8688:1
13Illness severity, viral shedding, and antibody responses in infants hospitalized with bronchiolitis caused by respiratory syncytial virus 显示文摘Wright PF Gruber WC Peters M 2002J Infect Dis2002,185,8:1
14Soft-tissue balance and alignment in medial unicompartmental knee arthroplasty显示文摘Emerson RH Jr Head WC Peters PC Jr 0,,06:1
15Expression of glutathione S-transferase alpha, P1-1 and T1-1 in the human gastrointestinal traet 显示文摘de Bruin WC Wagenmans MJ Peters WH 2000Cancer Res2000,91,3:1
16An extended trochanteric oateotomy for revision total hip replaenment显示文摘Peters PC Jr Head WC Emerson HH Jr 1993J Bone Joint Surg Br1993,75,:1
17Lipoprotein (a) serum concentration and apolipoprotein (a) phenotype correlate with severity and presence of ischemic cerebrovascular disease显示文摘Jurgens G Taddei Peters WC Koltringer P 1995Stroke1995,26,10:1
18Osehamivir and amantadine resistant influenza viruses A ( H1N 1 ) 显示文摘Peter KC Cheng Tommy WC Leung Eric CM Ho 2009Emerging Infectious Diseases2009,15,9:1
19Intraoperative magnetic resonance imaging: impact on brain tumor surgery显示文摘Michael S Peter WC 2003Cancer Control2003,10,2:1
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