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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Basic mechanical properties of retina in simple elongation显示文摘 | Wu W Peters WH 3rd Hammer ME | 1987 | Biomech Eng1987，109，1： | 1 |
| 3 | Glutathione S- transferases ia gastric carcinomas and in adjacent normal gastric epithelium: immunohistochemical and biochemical analyses 显示文摘 | Schipper DI Wagenmans MJ Peters WH | 1996 | Anticancer Res1996，16，6： | 1 |
| 4 | Glutathione S-transferase activity and subunit composition in transi- tional cell cancer and mucosa of the human bladder显示文摘 | Berendsen CL Peters WH Scheffer PG | 1997 | Urology1997，49，4： | 1 |
| 5 | The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility显示文摘 | Ebisch IM Thomas CM Peters WH | 2007 | Hum Reprod Update2007，13，： | 1 |
| 6 | Hom0cysteine, glutathione and related thiols affect fertility parameters in the (sub) fertile couple显示文摘 | Ebisch IM Peters WH Thomas CM | 2006 | Hum Reprod2006，21，： | 1 |
| 7 | Isoniazid and its toxic metabolite hydrazine induce in vitro pyrazinamide toxicity显示文摘 | Tostmann A Boeree MJ Peters WH | | 0，，06： | 1 |
| 8 | The importance of folate,zinc and antioxidants in the pathogenesis and prevention of subfertility显示文摘 | Ebisch IM Thomas CM Peters WH | | Human Reproduction0，，： | 1 |
| 9 | The influence of positive margins and nerve invasion in adenoid cystic carcinoma of the head and neck treated with surgery and radiation 显示文摘 | Garden AS Weber RS Morrison WH Ang KK Peters LJ | 1995 | Int J Radiat Oncol Bio Phys1995，32，3： | 1 |
| 10 | COX-2 polymorphisms and the risk for head and neck cancer in white patients 显示文摘 | Peters WH Lacko M Te Morsche RH | 2009 | Head Neck2009，31，： | 1 |
| 11 | Glutathione Stransferases and iododeoxyuridine labelling index during chemotherapy of gastric cancer 显示文摘 | Schipper DL Wagenmans MJ Peters WH | 2000 | Anticancer Res2000，20，3： | 1 |
| 12 | Combined polymorphisms in UDP-gluouronosyltranl transferases 1A1 and 1A6: implications for patient with Gilbert syndrome显示文摘 | Peter WH Temorsche RH Roelofs HM | 2003 | J Hepatol2003，38，： | 1 |
| 13 | Replication of CNTNAP2 association with nonwor d repetition and support for FOXP2 association with timed reading and motor activities in a dyslexis family sample显示文摘 | Peter B Raskind WH Matsushita M Lisowski M Vu T Beminger VW etal | | 0，，01： | 1 |
| 14 | Isoniazid and its toxic metabolite hydrazine induce in vitro pyrazinamide toxicity显示文摘 | Tostmann A Boeree MJ Peters WH | | 0，，06： | 1 |
| 15 | Variability of glutathione S - transferase alpha in human liver and plaama 显示文摘 | Mulder TP Court DA Peters WH | 1999 | Clin Chem1999，45，3： | 1 |
| 16 | Acute fatty liver in pregnancy显示文摘 | Tan AC van Krieken JH Peters WH | 2002 | Neth J Med2002，60，9： | 1 |
| 17 | Pathways from emotional adjustment to glycemic control in youths with diabetes in Hong Kong显示文摘 | Sunita MS Peter WH Louis CK | 2000 | Journal of Pediatric Psychology2000，25，6： | 1 |
| 18 | From gene to disease; unconjugated hyperbilirubinemia: Gilbertg syndrome and Crigler-Najjar types 1 and II显示文摘 | Drenth JP Peters WH Jansen JB | 2002 | Ned Tijdschr Genesekd2002，146，32： | 1 |
| 19 | Acute fatty liver in pregnancy显示文摘 | Tan AC van Krieken JH Peters WH | 2002 | Neth J Med2002，60，9： | 1 |
| 20 | A follow-up study of adherence and glycemic control among Hong Kong youths with diabetes显示文摘 | Sunita MS Peter WH David W | 2003 | Journal of Pediatric Psychology2003，28，1： | 1 |
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