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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Late abscess formation following indirect hernia repair utilizing silk suture 显示文摘 | Calkins CM St Peter SD Balcom A | 2007 | Pediatr Surg Int2007，23，4： | 1 |
| 3 | Tubular reabsorption and local production of urine hepcidin-25显示文摘 | Peters HP Laarakkers CM Pickkers P | 2013 | BMC nephrology2013，14，： | 1 |
| 4 | Tumor-induced injury of primary afferent sensory nerve fibers in bone cancer pain 显示文摘 | Peters CM Ghilardi JR Keyser CP | 2005 | Exp Neurnl2005，193，1： | 1 |
| 5 | Receptor and nonreceptor-mediated organ-specific toxicity of di (2-ethylhexyl) phthalate (DEHP) in peroxisome proliferator-activated receptor alpha-null mice 显示文摘 | Peters JM Perella CM | 1998 | Toxicol Pathol1998，26，： | 1 |
| 6 | The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility显示文摘 | Ebisch IM Thomas CM Peters WH | 2007 | Hum Reprod Update2007，13，： | 1 |
| 7 | Recepter and nonrecepter-nediated organ-specific toxicity of di(2-ethylhexyl) phthalate (DEHP) in peroxisone proliferator-activated receptor alpha-null mice显示文摘 | Peters JM Perella CM | 1998 | Toxicol Pathol1998，26，2： | 1 |
| 8 | Computed tomography-navi- gated transthoracic core biopsy of pulmonary lesions: which factors affect diagnostic yieht andcomplication rates? 显示文摘 | Heyer CM Reichelt S Peters SA | 2008 | Acad Radiol2008，15，8： | 1 |
| 9 | Hom0cysteine, glutathione and related thiols affect fertility parameters in the (sub) fertile couple显示文摘 | Ebisch IM Peters WH Thomas CM | 2006 | Hum Reprod2006，21，： | 1 |
| 10 | Serum hepcidin25 levels in patients with chronic kidney disease are independent of glomerular filtration rate显示文摘 | Peters HP Laarakkers CM Swinkels DW | | 0，，3： | 1 |
| 11 | Late abscess formation followingindirect hernia repair utilizing silk suture显示文摘 | Calkins CM Peter SD Balcom A | 2007 | Pediatr Surg Int2007，23，4： | 1 |
| 12 | Tumor-induced injury of primary afferent sensory Nerve fibers in bone cancer pain显示文摘 | Peters CM Ghilardi JR Keyser CP eta | 2005 | Exp Neurol2005，193，： | 1 |
| 13 | Late abscess formation following indirect hernia repair utilizing silk suture 显示文摘 | Calkins CM St Peter SD Balcom A | 2007 | Pediatr Surg Int2007，23，4： | 1 |
| 14 | The importance of folate,zinc and antioxidants in the pathogenesis and prevention of subfertility显示文摘 | Ebisch IM Thomas CM Peters WH | | Human Reproduction0，，： | 1 |
| 15 | Meta-analysis of new genome-wide association studies of colorectal cancer risk显示文摘 | Peters U Hutter CM Hsu L | | 0，，2： | 1 |
| 16 | Computed tomography-navigated transthoracic core biopsy of pulmonary lesions:which factors affect diagnostic yield and complication rates显示文摘 | Heyer CM Reichelt S Peters SA | | 0，，08： | 1 |
| 17 | Does smoking influence acne? 显示文摘 | Mills CM Peters TJ Finlay AY | 1993 | Clin Exp Dermatol1993，18，2： | 1 |
| 18 | Beliefs and social norms about codeine and promethazine hydrochloride cough syrup (CPHCS) onset and perceived addiction among urban Houstonian adolescents:an addiction trend in the city of lean显示文摘 | Peters RJ Jr Kelder SH Markham CM | 2003 | J Drug Educ2003，33，： | 1 |
| 19 | Cetirizine: A reappraisal of its pharmacological properties andtherapeutic uses in selected allergic disorders显示文摘 | Spencer CM Faulds D Peter DH | 1993 | Drugs1993，46，7： | 1 |
| 20 | Serum hep- cidin-25 levels in patients with chronic kidney disease are independent of glomentlar filtration rate 显示文摘 | Peters HP Laarakkers CM Swinkels DW | 2010 | Nephrol Dial Transplant2010，25，3： | 1 |
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