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| 1 | Mechanisms of biliary carcinogenesis and growth显示文摘Cholangiocarcinoma is a rare cancer originating from the neoplastic transformation of the epithelial cells (i.e. cholangiocytes) that line the biliary tract. The prognosis for patients with cholangiocarcinoma is grim due to lack of viable treatment options. The increase in world-wide incidence and mortality from cholangiocarcinoma highlights the importance of understanding the intracellular mechanisms that trigger the neoplastic transformation of cholangiocytes and the growth of biliary cancers. The purpose of the following review is to address what has been learned over the past decade concerning the molecular basis of cholangiocarcinogenesis. The material presented is divided into two sections:(1) mechanisms regulating neoplastic transformation of cholangiocytes; and (2) factors regulating cholangiocarcinoma growth. An understanding of the growth regulatory mechanisms of cholangiocarcinoma will lead to the identification of therapeutic targets for this devastating cancer. | Candace Wise Metaneeya Pilanthananond Benjamin F Perry Gianfranco Alpini Michael McNeal Shannon S Glaser | 2008 | World Journal of Gastroenterology2008，14，19： | 5 |
| 2 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 3 | Th1/Th2 cytomet- rie bead array can discriminate cytokine secretion from endogenously activated cells in pulmonary disease, re- cent and remote infection in tuberculosis显示文摘 | Talat N Shahid F Perry S | 2011 | Cytokine2011，54，2： | 1 |
| 4 | Crystal structures of the ribosome in complex with release factors RFI and RF2 Bound to a cognate stop codon 显示文摘 | Perry S Brodersen D E Murphy F V 4th | 2005 | Cell2005，123，7： | 1 |
| 5 | Renal expression and localization of SLC9A3 sodium/hydrogen exchanger and its possible role in acid-base regulation in freshwater rainbow trout ( Oncorhynchus mykiss ) 显示文摘 | IVANIS G BRAUN M PERRY S F | 2008 | American Journal of Physiology: Regulatory Integrative and Comparative Physiology2008，295，3： | 1 |
| 6 | Optimal design of mixed refrigerant cycles 显示文摘 | NOGAL F KIM J PERRY S | 2008 | Ind Eng Chem Res2008，47，3： | 1 |
| 7 | beta-arrestin 1 and 2 dif-ferentially regulate heptahelical receptor signaling and trafficking显示文摘 | Kohout T A Lin F T Perry S J | 2001 | Proc Natl Acad Sci USA2001，98，4： | 1 |
| 8 | Expression of nm23, MMP - 2, TIMP - 2 in breast neoplasm in Zhengzhou Center Hospital, China显示文摘 | Peihong S Perry F | 2007 | Ethiop Med J2007，45，1： | 1 |
| 9 | Opacity measurements in a hot dense medium显示文摘 | Perry T S Davidson S J Serduke F J D | 1991 | Phys Rev Lett1991，67，： | 1 |
| 10 | PCR characterization and typing of Klebsiella pneumoniae using capsular type-specific, variable number tandem repeat and virulence gene targets 显示文摘 | Turton J F Perry C Elgohari S | 2010 | J Med Microbiol2010，59，5： | 1 |
| 11 | Ultrabright supramolecular beacons based on the self-assembly of two-photon chromophores on metal nanoparticles 显示文摘 | Stellacci F Marder S R Perry J W | 2003 | J Am Chem Soc2003，125，： | 1 |
| 12 | The preparation and properties of thiocarbohydrazide显示文摘 | Audrieth L F Earle S S Perry S K | 1954 | J Org Chem1954，19，： | 1 |
| 13 | Characterization of branchial transepithelial calcium fluxes in freshwater trout, Salmo gairdneri 显示文摘 | Perry S F Flik G | 1988 | Am J Physiol Regul Integr Comp Physiol1988，254，： | 1 |
| 14 | Cardiovascular actions of cadmium at environmentalexposure levels 显示文摘 | Kopp S J Glonek T Jr Perry H M Erlanger M Perry E F | 1982 | Science1982，217，4562： | 1 |
| 15 | Urea excretion as astrategy for survival in a fish living in a very alkaline environment显示文摘 | Randall D J Wood C M Perry S F | 1989 | Nature1989，337，6203： | 1 |
| 16 | Direct evidence for rapid and selective induction of tumor neovascular permeability by tumor nec- rosis factor and a novel derivative, colloidal gold bound tumor necro- sis factor显示文摘 | Jeffrey M F Markus P Perry A S | 2007 | Int J Cancer2007，120，： | 1 |
| 17 | Respiratory and acid-base pathophysiology of hydrogen peroxide in rainbow trout (Oncorhynchus mykiss Walbaum) 显示文摘 | Powell M D Perry S F | 1997 | Aquatic Toxicology1997，37，23： | 1 |
| 18 | Sedimentary evolution of the Mesozoic continental redbeds using geochemical and mineralogical tools:The case of Upper Triassic to Lowermost Jurassic Monte di Gioiosa mudrocks(Sicily,southern Italy)显示文摘 | Perri F Critelli S Mongelli G | 2011 | International Journal of Earth Sciences2011，100，： | 1 |
| 19 | Bone marrow as a cell a source for tissue engineering heart vahes 显示文摘 | PERRY T E KAUSHAL S SUTHERLAND F W H | 2003 | Ann Thorac Surg2003，75，： | 1 |
| 20 | Subjective improve- ment of olfactory function after endoscopic sinus sur- gery for chronic rhinosinusitis显示文摘 | PERRY B F KOUNTAKIS S E | 2003 | Am J otolaryngol2003，24，： | 1 |
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