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| 1 | Aspirin responsive platelet thrombophilia in essential thrombocythemia and polycythemia vera显示文摘Essential thrombocythemia(ET) and polycythemia vera(PV) frequently present with erythromelalgia and acrocyanotic complications, migraine-like microvascular cerebral and ocular transient ischemic attacks(MIAs) and/or acute coronary disease. The spectrum of MIAs in ET range from poorly localized symptoms of transient unsteadiness, dysarthria and scintillating scotoma to focal symptoms of transient monocular blindness, transient mono- or hemiparesis or both. The attacks all have a sudden onset, occur sequentially rather than simultaneously, last for a few seconds to several minutes and are usually associated with a dull, pulsatile or migraine-like headache. Increased hematocrit and blood viscosity in PV patients aggravate the microvascular ischemic syndrome of thrombocythemia to major arterial and venous thrombotic complications. Phlebotomy to correct hematocrit to normal in PV significantly reduces major arterial and venous thrombotic complications, but fails to prevent the platelet-mediated erythromelalgia and MIAs. Complete long-term relief of the erythromelalgic microvascular disturbances, MIAs and major thrombosis in ET and PV patients can be obtained with low dose aspirin and platelet reduction to normal, but not with anticoagulation. Skin punch biopsies from the erythromelalgic area show fibromuscular intimal proliferation of arterioles complicated by occlusive plateletrich thrombi leading to acrocyanotic ischemia. Symptomatic ET patients with erythromelalgic microvascular disturbances have shortened platelet survival, increased platelet activation markers β-thromboglobulin(β-TG), platelet factor 4(PF4) and thrombomoduline(TM), increased urinary thromboxane B2(TXB2) excretion, and no activation of the coagulation markers thrombin fragments F1+2 and fibrin degradation products. Inhibition of platelet cyclooxygenase(COX1) by aspirin is followed by the disappearance and no recurrence of microvascular disturbances, increase in platelet number, correction of the shortened platelet survival times to normal, and reduction of increased plasma levels of β-TG, PF4, TM and urinary TXB2 excretion to normal. These results indicate that platelet-mediated fibromuscular intimal proliferation and platelet-rich thrombi in the peripheral, cerebral and coronary end-arterial microvasculature are responsible for the erythromelalgic ischemic complica-tions, MIAs and splanchnic vein thrombosis. Baseline platelet P-selectin levels and arachidonic acid induced COX1 mediated platelet activation showed a highly significant increase of platelet P-selectin expression(not seen in ADP and collagen stimulated platelets), which was significantly higher in JAK2V617 F mutated compared to JAK2 wild type ET. | Jan Jacques Michiels Fibo WJ Ten Kate Peter J Koudstaal Perry JJ Van Genderen | 2013 | World Journal of Hematology2013，2，2： | 4 |
| 2 | A prospective cohort study of patients with transient ischemic attack to identify high-risk clinical characteristics显示文摘 | Perry JJ Sharma M Sivilotti ML | 2014 | Stroke2014，45，1： | 1 |
| 3 | Salmonella enteritidis in shell eggs: evolving concerns and innovative control measures 显示文摘 | Perry JJ Yousef A | 2012 | Adv Appl Microbiol2012，81，5： | 1 |
| 4 | New techniques for biopsy and culture of human olfactory epithelial neurons显示文摘 | Feron F Perry C McGrath JJ | 1998 | Arch Otolaryngol Head Neck Surg1998，124，8： | 1 |
| 5 | Prospective relations between helicobacter pylori infection,coronary heart disease,and stroke in middle and aged men显示文摘 | Whincup PH Mendall MA Perry JJ | | 0，，： | 1 |
| 6 | Optimized cryopreservation method for human dental pulp-derived stem cells and their tissues of origin for bankin g and clinical use显示文摘 | Woods EJ Perry BC Hockema JJ | | 0，，02： | 1 |
| 7 | High risk clinical characteristics for subarachnoid haemorrhage in patients with acute headache:prospective cohort study显示文摘 | Perry JJ Sdell IG Sivilotti MLA | | 0，，： | 1 |
| 8 | The stability, reliability, andvalid- ity of videofluoroseopy measures for patients with head andneck cancer 显示文摘 | Frowen JJ Cotton SM Perry AR | 2008 | Dysphagia2008，23，4： | 1 |
| 9 | Induced plufipotent stem cells for the study of cardiovascular disease 显示文摘 | Savla JJ Nelson BC Perry CN | 2014 | J Am Col/ Cardiol2014，64，5： | 1 |
| 10 | Prospective validation of the ABCD2 score for patients in the emergency department with transient ischemic attack显示文摘 | Perry JJ Sharma M Sivilotti ML | 2011 | CMAJ2011，183，： | 1 |
| 11 | Do statins improve outcomes and reduce the incidence of vasospasm after aneurysmal subarachnoid hemorrhage: a meta-analysis显示文摘 | Sillberg VA Wells GA Perry JJ | 2008 | Stroke2008，39，9： | 1 |
| 12 | Double umbrella closure atrial defects:initial clinical applications显示文摘 | Kean JF Perry SB | 1990 | Circulation1990，82，： | 1 |
| 13 | The stability, reliability, andvalidity of videofluoroseopy measures for patients with head and neck cancer显示文摘 | Frowen JJ Cotton SM Perry AR | 2008 | Dysphagia2008，23，4： | 1 |
| 14 | Double-umbrella closure of atrial defects:initial clinical applications显示文摘 | Rome JJ Keane JF Perry SB | 1990 | Circulation1990，82，： | 1 |
| 15 | Osteosar-coma arising in heterotopic ossification of dermatomyositis : case report and review of the literature显示文摘 | Eckardt JJ Ivins JC Perry HO | 1981 | Cancer1981，48，5： | 1 |
| 16 | The stability, reliability, and validity of videofluoroseopy measures for patients with head and neck eaneer显示文摘 | Frowen JJ Cotton SM Perry AR | 2008 | Dysphagia2008，23，： | 1 |
| 17 | Clinicaluse of ceftriaxone:a pharmacokinetic- pharmacodynamic perspective on the impact of minimum inhibitory concentration and serum protein binding显示文摘 | Perry TR Schentag JJ | 2001 | Clin Pharmacokinet2001，40，9： | 1 |
| 18 | Do statins improve outcomes and reduce the incidence of vasospasm after aneurysmal subarachnoid hemorrhage? : a meta-analysis 显示文摘 | SILLBERG VA WELLS GA PERRY JJ | 2008 | Stroke2008，39，9： | 1 |
| 19 | Contraction aad growth of wounds covered by meshed and non-meshed split thickness skin grafts显示文摘 | Perry JJ Wortham KA | 1986 | Br J Piast Surg1986，39，4： | 1 |
| 20 | Prospective validation of the ABCD' score for patients in the emergency department with transient ischemic attack显示文摘 | Perry JJ Sharma M Sivilotti ML | 2011 | CMAJ2011，183，： | 1 |
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