|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | Intramedullary nailing of clavicular midshaft fractures with the titanium elastic nail:problems and complications显示文摘 | Frigg A Rillmann P Perren T | 2009 | Am J Sports Med2009，37，2： | 1 |
| 3 | Lymphomas of the cervix and upper vagina:A report of five cases and a review of the literature显示文摘 | Perren T Farrant M McCarthy K | 1992 | Gynecol Oncol1992，44，： | 1 |
| 4 | Corrosion resistance of super duplex stainless steels in chloride ion containing environments显示文摘 | R A Perren T Suter C Solenthaler etc | 2001 | Corrosion Science2001，43，： | 1 |
| 5 | Detection of coloreetal cancer cells in peripheral blood by reverse transcriptase polymerase chain reaction for cytokeratin 20 显示文摘 | Wyld D K Selby P Perren T J | 1998 | Int J Cancer1998，79，3： | 1 |
| 6 | Detection of Colorectal Cancer Cslls in Peripheral Blood by Reverse-transcriptase Polymerase Chain Reaction for Cytokeratin 20显示文摘 | Wyld D K Siby P Perren T J | 1998 | Int J Cancer1998，79，3： | 1 |
| 7 | Vertebral artery hypoplasia:apredisposing factor for posterior circulation stroke?显示文摘 | Perren F Poglia D Landis T | 2007 | Neurology2007，68，1： | 1 |
| 8 | Glutathione re-duces the toxicity and improves quality of life of womendiagnosed with ovarian cancer treated with cisplatin: re-sults of a double-blind, randomised trial显示文摘 | Smyth JF Bowman A Perren T | 1997 | Ann Oncol1997，8，6： | 1 |
| 9 | Vertebral artery hypoplasia:A predisposing factor for posterior circulation stroke?显示文摘 | Perren F Poglia D Landis T | 2007 | Neurology2007，68，： | 1 |
| 10 | A selective COX-2 inhibitor suppresses chronic pancreatitis in an animal model(WBN/Kob rats) : significant reduction of macro phage infiltration and fibrosis显示文摘 | Reding T Bimmler D Perren A | 2006 | Gut2006，55，8： | 1 |
| 11 | From amaurosis fugax to asymptomatic bithalamic infarct显示文摘 | Emond H Landis T Perren F | 2009 | J Neurol2009，256，6： | 1 |
| 12 | New surgical treatment procedures in fractures of the distal tibia显示文摘 | Ryf C G(o)tsch U Perren T | | 0，，： | 1 |
| 13 | Bullying in school and cy-berspace:Associations with depressive symptoms in swiss and austral-ian adolescents显示文摘 | PERREN S DOOLEY J SHAW T | 2010 | Child Adoles Psychiatry Ment Health2010，4，11： | 1 |
| 14 | lntramedullary nailing of clavicular midshaft fractures wilh the litaniunl elastic nail:problenls and complicalions 显示文摘 | Frigg A Rillmann P Perren T el al | 2009 | Am J Sporls Med2009，37，2： | 1 |
| 15 | Are the terms 'biology' and 'osteosynthesis' contradictory? 显示文摘 | Perren SM Perren T Schneider E | 2003 | Ther Umsch2003，60，12： | 1 |
| 16 | Vertebral artery hypoplasia:a pre-disposing factor for posterior circulation stroke?显示文摘 | Perren F Poglia D Landis T | 2007 | Neurology2007，68，22： | 1 |
| 17 | Vertebral artery hypoplasia: a predisposing factor for posterior circulation stroke 显示文摘 | Perren F Poglia D Landis T | 2007 | Neurology2007，68，1： | 1 |
| 18 | Detection of colorectal cancer cells in peripheral blood by reverse-transcriptase polymerase chain reaction for cytokeratin 20 显示文摘 | Wyld D K Selby P perren T J | 1998 | Int J Cancer1998，79，3： | 1 |
| 19 | Vertebral artery hypoplasia:A predisposing factor for posterior circulation stroke?显示文摘 | Perren F Poglia D Landis T | 2007 | Neurology2007，68，1： | 1 |
| 20 | Glutathione reduced the toxicity and improves quality of life of women diagnosed with ovarian cancer treated with cisplatin:Results of a double blind randomised trial 显示文摘 | Smythj F Bowman A Perren T | 1997 | Ann Oncol1997，8，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员