|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hallmarks in colorectal cancer:Angiogenesis and cancer stem-like cells显示文摘Carcinogenesis is a multistep process that requires the accumulation of various genetic and epigenetic aberrations to drive the progressive malignant transformation of normal human cells.Two major hallmarks of carcinogenesis that have been described are angiogenesis and the stem cell characteristic of limitless replicative potential.These properties have been targeted over the past decade in the development of therapeutic treatments for colorectal cancer(CRC),one of the most commonly diagnosed and lethal cancers worldwide.The treatment of solid tumor cancers such as CRC has been challenging due to the heterogeneity of the tumor itself and the chemoresistance of the malignant cells.Furthermore,the same microenvironment that maintains the pool of intestinal stem cells that contribute to the continuous renewal of the intestinal epithelia also provides the necessary conditions for proliferative growth of cancer stem-like cells.These cancer stem-like cells are responsible for the resistance to therapy and cancer recurrence,though they represent less than 2.5%of the tumor mass.The stromal environment surrounding the tumor cells,referred to as the tumor niche,also supports angiogenesis,which supplies the oxygen and nutrients needed for tumor development.Anti-angiogenic therapy,such as with bevacizumab,a monoclonal antibody against vascular-endothelial growth factor,significantly prolongs the survival of metastatic CRC patients.However,such treatments are not completely curative,and a large proportion of patient tumors retain chemoresistance or show recurrence.This article reviews the current knowledge regarding the molecular phenotype of CRC cancer cells,as well as discusses the mechanisms contributing to their maintenance.Future personalized therapeutic approaches that are based on the interaction of the carcinogenic hallmarks,namely angiogenic and proliferative attributes,could improve survival and decrease adverse effects induced by unnecessary chemotherapy. | Muriel Mathonnet Aurelie Perraud Niki Christou Hussein Akil Carole Melin Serge Battu Marie-Odile Jauberteau Yves Denizot | 2014 | World Journal of Gastroenterology2014，20，15： | 5 |
| 2 | Tropomyosin-related kinase B/brain derived-neurotrophicfactor signaling pathway as a potential therapeutic targetfor colorectal cancer显示文摘Colorectal cancer(CRC) is the second most common cause of cancer-related death in western countries. Approximately one-quarter of newly diagnosed patients for CRC have metastases, and a further 40%-50% experience disease recurrence or develop metastases after all standard therapies. Therefore, understanding the molecular mechanisms involved in the progression of CRC and subsequently developing novel therapeutic targets is crucial to improve management of CRC and patients' long-term survival. Several tyrosine kinase receptors have been implicated in CRC development, progression and metastasis, including epidermal growth factor receptor(EGFR) and vascular EGFR. Recently, tropomyosin-related kinase B(Trk B), a tyrosine kinase receptor, has been reported in CRC and found to clearly exert several biological and clinical features, such as tumor cell growth and survival in vitro and in vivo, metastasis formation and poor prognosis. Here we review the significance of Trk B and its ligand brain derived-neurotrophic factor in CRC. We focus on their expression in CRC tumor samples, and their functional roles in CRC cell lines and in in vivo models. Finally we discuss therapeutic approaches that can lead to the development of novel therapeutic agents for treating Trk B-expressing CRC tumors. | Hussein Akil Aurélie Perraud Marie-Odile Jauberteau Muriel Mathonnet | 2016 | World Journal of Gastroenterology2016，22，2： | 3 |
| 3 | The promoter of the hu- man cystic fibrosis transmembrane conductance regulator gene directing SV40 T antigen expression induces malignant prolifera tion of ependymal cells in transgenic mice显示文摘 | Perraud F Yoshimura K Louis B | 1992 | Oncogene1992，7，5： | 1 |
| 4 | Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its α-kinase domain显示文摘 | Alvaro Yogi Glaucia E. Callera Sarah O’Connor Tayze T. Antunes William Valinsky Perrine Miquel Augusto C.I. Montezano Anne-Laure Perraud Carsten Schmitz Alvin Shrier Rhian M. Touyz | 2013 | Cellular Signalling2013，，： | 1 |
| 5 | Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase显示文摘 | PERRAUD A L SHEN NUDT9 a member of the B DUNN C A | 2003 | The Journal Biological Chemis- try2003，278，3： | 1 |
| 6 | The Multifunctionality of Agriculture and Contractual Policies,a Comparative Analysis of France and the Netherlands显示文摘 | Daniel F J Perraud D | 2009 | Journal of Environmental Management2009，，： | 1 |
| 7 | Predictors of compliance with a home-based exercise program added to usua lmedical care in preventing postmenopausal osteoporosis: an 18-month prospective study显示文摘 | Mayoux-Benhamou M A Roux C Perraud A | 2005 | Osteoooros Int2005，16，： | 1 |
| 8 | Characterization of a lipoxygenase extract from Gertrichum candidum 显示文摘 | Perraud X Kermasha S Bisakowski B | 1999 | Process Biochemistry1999，34，： | 1 |
| 9 | TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization 显示文摘 | Launay P Fleig A Perraud AL | 2002 | Cell2002，109，： | 1 |
| 10 | Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels显示文摘 | PERRAUD A L TAKANISHI C L SHEN B | 2005 | The Journal of Biology Chemistry2005，280，： | 1 |
| 11 | Comparison of several local soil management techniques implemented in Champagne vineyards显示文摘 | Descotes A Moncomble D Perraud A | 1996 | Seizieme conference du Columa1996，3，： | 1 |
| 12 | TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization 显示文摘 | Launay P Fleig A Perraud AL | 2002 | Cell2002，109，： | 1 |
| 13 | Automatic transition predictions using simplified methods 显示文摘 | Perraud J Arnal D Casalis G | 2009 | AIAA Paper2009，，： | 1 |
| 14 | Reactive astrogliosis after basic fibroblast grouth factor (bFGF) injection in injured neonatal rat brain 显示文摘 | Eclancher F Perraud F Faltin J | 1990 | Glia1990，3，： | 1 |
| 15 | Characterization of a lipoxy- genase extract from Geotrichum candidum显示文摘 | Perraud X Kermasha S Bisanowski B | 1999 | Process Biochemistry1999，34，8： | 1 |
| 16 | ADP-ribose gating of the cal-cium-permeable LTRPC2 channel revealed by Nudix motif homolo-gy显示文摘 | Perraud AL Fleig A Dunn CA | 2001 | Nature2001，411，6837： | 1 |
| 17 | Expression of p53 and DR5 in normal and malignant tissues of colorectal cancer:correlation with advanced stages显示文摘 | PERRAUD A AKIL H NOUAILLE M | 2011 | Oncol Rep2011，26，5： | 1 |
| 18 | Critical intracellular Ca2+dependence of transient receptor potential melastatin 2(TRPM2)cation channel activation显示文摘 | Mchugh D Flemming R Xu SZ Perraud AL Beech DJ | 2003 | J Biol Chem2003，278，11： | 1 |
| 19 | Molecular components of vertebrate Mg^2+-homeostasis regulation 显示文摘 | Carsten Schmitz Francina Deason Anne-Laure Perraud | 2007 | Magnesium Research2007，20，1： | 1 |
| 20 | Identification of Ser/Thr phosphorylation sites in the C2-domain of phospholipase C 72 (PLC,/2) using TRPM7-kinase显示文摘 | Towne F Perraud AL Schmitz C | 2012 | Cell Signal2012，24，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员