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| 1 | Effects of growth temperature on μc-Si:H films prepared by plasma assistant magnetron sputtering显示文摘Hydrogenated microcrystalline silicon thin films (μc-Si:H) were deposited by plasma assistant magnetron sputtering in Ar-H 2 gas mixture. The effects of growth temperature from 150 to 450 C on properties of deposited Si films were investigated at two different hydrogen diluted gases with [H 2 ]/([Ar]+[H 2 ]) of 10% and 50% at 3 Pa. The crystallinity of Si films examined by Raman scattering exhibited higher degrada- tion by lowering growth temperature from 250 to 150 C in low hydrogen diluted gas of 10% than that in high hydrogen diluted gas of 50%. The IR absorption band around 845 and 890 cm 1 as well as calculated concentration of bonded hydrogen showed more obvious decrease of samples deposited in low hydrogen diluted gas of 10% than that in high hydrogen diluted gas of 50%. The optical band gasps of both groups of samples measured by ultraviolet-visible optical absorption were decreased with increasing temperature in both gas conditions. | Su, Yuanjun Dond, Chuang Zhu, Ming Xu, Jun Fan, Penghui | 2012 | Rare Metals2012，31，2： | 3 |
| 2 | Hard nanocrystalline gold materials prepared via high-pressure phase transformation显示文摘As one of the important materials,nanocrystalline Au(n-Au)has gained numerous interests in recent decades owing to its unique properties and promising applications.However,most of the current n-Au thin films are supported on substrates,limiting the study on their mechanical properties and applications.Therefore,it is urgently desired to develop a new strategy to prepare nAu materials with superior mechanical strength and hardness.Here,a hard n-Au material with an average grain size of~40 nm is prepared by cold-forging of the unique Au nanoribbons(NRBs)with unconventional 4H phase under high pressure.Systematic characterizations reveal the phase transformation from 4H to face-centered cubic(fcc)phase during the cold compression.Impressively,the compressive yield strength and Vickers hardness(HV)of the prepared n-Au material reach~140.2 MPa and~1.0 GPa,which are 4.2 and 2.2 times of the microcrystalline Au foil,respectively.This work demonstrates that the combination of high-pressure cold-forging and the in-situ 4H-to-fcc phase transformation can effectively inhibit the grain growth in the obtained n-Au materials,leading to the formation of novel hard n-Au materials.Our strategy opens up a new avenue for the preparation of nanocrystalline metals with superior mechanical property. | Chenlong Xie Wenxin Niu Penghui Li Yiyao Ge Jiawei Liu Zhanxi Fan Xiaoxiao Liu Ye Chen Ming Zhou Zihe Li Mengdong Ma Yonghai Yue Jing Wang Li Zhu Kun Luo Yang Zhang Yingju Wu Lin Wang Bo Xu Hua Zhang Zhisheng Zhao Yongjun Tian | 2022 | Nano Research2022，15，7： | 0 |
| 3 | The 2009 pandemic A/Wenshan/01/2009 H1N1 induces apoptotic cell death in human airway epithelial cells显示文摘In 2009,a novel swine-origin H1N1 influenza virus emerged in Mexico and quickly spread to other countries,including China.This 2009 pandemic H1N1 can cause human respiratory disease,but its pathogenesis remains poorly understood.Here,we studied the infection and pathogenesis of a new 2009 pandemic strain,A/Wenshan/01/2009 H1N1,in China in human airway epithelial cell lines compared with contemporary seasonal H1N1 influenza virus.Our results showed that viral infection by the A/Wenshan H1N1 induced significant apoptotic cell death in both the human nasopharyngeal carcinoma cell line CNE-2Z and the human lung adenocarcinoma cell line A549.The A/Wenshan H1N1 virus enters both of these cell types more efficiently than the seasonal influenza virus.Viral entry in both cell lines was shown to be mediated by clathrin-and dynamin-dependent endocytosis.Therefore,we discovered that the 2009 pandemic H1N1 strain,A/Wenshan/01/2009,can induce apoptotic cell death in epithelial cells of the human respiratory tract,suggesting a molecular pathogenesis for the 2009 pandemic H1N1. | Ning Yang Xiaoxu Hong Penghui Yang Xiangwu Ju Yuguo Wang Jun Tang Chenggang Li Quanshui Fan Fuqiang Zhang Zhongwei Chen Li Xing Zhongpeng Zhao Xiao Gao Guoyang Liao Qihan Li Xiliang Wang Dangsheng Li Chengyu Jiang | 2011 | Journal of Molecular Cell Biology2011，3，4： | 0 |
| 4 | Ghost-Retina Net:Fast Shadow Detection Method for Photovoltaic Panels Based on Improved Retina Net显示文摘Based on the artificial intelligence algorithm of RetinaNet,we propose the Ghost-RetinaNet in this paper,a fast shadow detection method for photovoltaic panels,to solve the problems of extreme target density,large overlap,high cost and poor real-time performance in photovoltaic panel shadow detection.Firstly,the Ghost CSP module based on Cross Stage Partial(CSP)is adopted in feature extraction network to improve the accuracy and detection speed.Based on extracted features,recursive feature fusion structure ismentioned to enhance the feature information of all objects.We introduce the SiLU activation function and CIoU Loss to increase the learning and generalization ability of the network and improve the positioning accuracy of the bounding box regression,respectively.Finally,in order to achieve fast detection,the Ghost strategy is chosen to lighten the size of the algorithm.The results of the experiment show that the average detection accuracy(mAP)of the algorithm can reach up to 97.17%,the model size is only 8.75 MB and the detection speed is highly up to 50.8 Frame per second(FPS),which can meet the requirements of real-time detection speed and accuracy of photovoltaic panels in the practical environment.The realization of the algorithm also provides new research methods and ideas for fault detection in the photovoltaic power generation system. | Jun Wu Penghui Fan Yingxin Sun Weifeng Gui | 2023 | Computer Modeling in Engineering & Sciences2023，，2： | 0 |
| 5 | Grid cell remapping under three-dimensional object and social landmarks detected by implantable microelectrode arrays for the medial entorhinal cortex显示文摘Grid cells with stable hexagonal firing patterns in the medial entorhinal cortex(MEC)carry the vital function of serving as a metric for the surrounding environment.Whether this mechanism processes only spatial information or involves nonspatial information remains elusive.Here,we fabricated an MEC-shaped microelectrode array(MEA)to detect the variation in neural spikes and local field potentials of the MEC when rats forage in a square enclosure with a planar,three-dimensional object and social landmarks in sequence.The results showed that grid cells exhibited rate remapping under social conditions in which spike firing fields closer to the social landmark had a higher firing rate.Furthermore,global remapping showed that hexagonal firing patterns were rotated and scaled when the planar landmark was replaced with object and social landmarks.In addition,when grid cells were activated,the local field potentials were dominated by the theta band(5–8 Hz),and spike phase locking was observed at troughs of theta oscillations.Our results suggest the pattern separation mechanism of grid cells in which the spatial firing structure and firing rate respond to spatial and social information,respectively,which may provide new insights into how the brain creates a cognitive map. | Zhaojie Xu Fan Mo Gucheng Yang Penghui Fan Yiding Wang Botao Lu Jingyu Xie Yuchuan Dai Yilin Song Enhui He Shihong Xu Juntao Liu Mixia Wang Xinxia Cai | 2022 | Microsystems & Nanoengineering2022，8，5： | 0 |
| 6 | High-throughput transcriptional profiling of perturbations by Panax ginseng saponins and Panax notoginseng saponins using TCM-seq显示文摘Panax ginseng(PG)and Panax notoginseng(PN)are highly valuable Chinese medicines(CM).Although both CMs have similar active constituents,their clinical applications are clearly different.Over the past decade,RNA sequencing(RNA-seq)analysis has been employed to investigate the molecular mechanisms of extracts or monomers.However,owing to the limited number of samples in standard RNA-seq,few studies have systematically compared the effects of PG and PN spanning multiple conditions at the transcriptomic level.Here,we developed an approach that simultaneously profiles transcriptome changes for multiplexed samples using RNA-seq(TCM-seq),a high-throughput,low-cost workflow to molecularly evaluate CM perturbations.A species-mixing experiment was conducted to illustrate the accuracy of sample multiplexing in TCM-seq.Transcriptomes from repeated samples were used to verify the robustness of TCM-seq.We then focused on the primary active components,Panax notoginseng saponins(PNS)and Panax ginseng saponins(PGS)extracted from PN and PG,respectively.We also characterized the transcriptome changes of 10 cell lines,treated with four different doses of PNS and PGS,using TCM-seq to compare the differences in their perturbing effects on genes,functional pathways,gene modules,and molecular networks.The results of transcriptional data analysis showed that the transcriptional patterns of various cell lines were significantly distinct.PGS exhibited a stronger regulatory effect on genes involved in cardiovascular disease,whereas PNS resulted in a greater coagulation effect on vascular endothelial cells.This study proposes a paradigm to comprehensively explore the differences in mechanisms of action between CMs based on transcriptome readouts. | Junyun Cheng Jie Chen Jie Liao Tianhao Wang Xin Shao Jinbo Long Penghui Yang Anyao Li Zheng Wang Xiaoyan Lu Xiaohui Fan | 2023 | Journal of Pharmaceutical Analysis2023，13，4： | 0 |
| 7 | Recent advances and research progress on microsystems and bioeffects of terahertz neuromodulation显示文摘Terahertz waves can interact with the nervous system of organisms under certain conditions.Compared to common optical modulation methods,terahertz waves have the advantages of low photon energy and low risk;therefore,the use of terahertz waves to regulate the nervous system is a promising new method of neuromodulation.However,most of the research has focused on the use of terahertz technology for biodetection,while relatively little research has been carried out on the biological effects of terahertz radiation on the nervous system,and there are almost no review papers on this topic.In the present article,we begin by reviewing principles and objects of research regarding the biological effects of terahertz radiation and summarizing the current state of related research from a variety of aspects,including the bioeffects of terahertz radiation on neurons in vivo and in vitro,novel regulation and detection methods with terahertz radiation devices and neural microelectrode arrays,and theoretical simulations of neural information encoding and decoding.In addition,we discuss the main problems and their possible causes and give some recommendations on possible future breakthroughs.This paper will provide insight and assistance to researchers in the fields of neuroscience,terahertz technology and biomedicine. | Meiting Liu Juntao Liu Wei Liang Botao Lu Penghui Fan Yilin Song Mixia Wang Yirong Wu Xinxia Cai | 2023 | Microsystems & Nanoengineering2023，9，6： | 0 |
| 8 | M1 macrophage-related gene model for NSCLC immunotherapy response prediction显示文摘Patients diagnosed with non-small cell lung cancer(NSCLC)have a limited lifespan and exhibit poor immunotherapy outcomes.M1 macrophages have been found to be essential for antitumor immunity.This study aims to develop an immunotherapy response evaluation model for NSCLC patients based on transcription.RNA sequencing profiles of 254 advanced-stage NSCLC patients treated with immunotherapy are downloaded from the POPLAR and OAK projects.Immune cell infiltration in NSCLC patients is examined,and thereafter,different coexpressed genes are identified.Next,the impact of M1 macrophage-related genes on the prognosis of NSCLC patients is investigated.Six M1 macrophage coexpressed genes,namely,NKX2-1,CD8A,SFTA3,IL2RB,IDO1,and CXCL9,exhibit a strong association with the prognosis of NSCLC and serve as effective predictors for immunotherapy response.A response model is constructed using a Cox regression model and Lasso Cox regression analysis.The M1 genes are validated in our TD-FOREKNOW NSCLC clinical trial by RT-qPCR.The response model shows excellent immunotherapy response prediction and prognosis evaluation value in advanced-stage NSCLC.This model can effectively predict advanced NSCLC prognosis and aid in identifying patients who could benefit from customized immunotherapy as well as sensitive drugs. | Sifan Wu Qiqi Sheng Pengjun Liu Zhe Jiao Jinru Lv Rong Qiao Dongkun Xie Zanhan Wang Jiamei Ge Penghui Li Tiaoxia Wei Jie Lei Jieyi Fan Liang Wang | 2024 | Acta Biochimica et Biophysica Sinica2024，56，3： | 0 |
| 9 | Detection of neuronal defensive discharge information transmission and characteristics in periaqueductal gray double-subregions using PtNP/PEDOT:PSS modified microelectrode arrays显示文摘Threatened animals respond with appropriate defensive behaviors to survive.It has been accepted that midbrain periaqueductal gray(PAG)plays an essential role in the circuitry system and organizes defensive behavioral responses.However,the role and correlation of different PAG subregions in the expression of different defensive behaviors remain largely unexplored.Here,we designed and manufactured a microelectrode array(MEA)to simultaneously detect the activities of dPAG and vPAG neurons in freely behaving rats.To improve the detection performance of the MEAs,PtNP/PEDOT:PSS nanocomposites were modified onto the MEAs.Subsequently,the predator odor was used to induce the rat’s innate fear,and the changes and information transmission in neuronal activities were detected in the dPAG and vPAG.Our results showed that the dPAG and vPAG participated in innate fear,but the activation degree was distinct in different defense behaviors.During flight,neuronal responses were stronger and earlier in the dPAG than the vPAG,while vPAG neurons responded more strongly during freezing.By applying high-performance MEA,it was revealed that neural information spread from the activated dPAG to the weakly activated vPAG.Our research also revealed that dPAG and vPAG neurons exhibited different defensive discharge characteristics,and dPAG neurons participated in the regulation of defense responses with burst-firing patterns.The slow activation and continuous firing of vPAG neurons cooresponded with the regulation of long-term freezing responses.The results demonstrated the important role of PAG neuronal activities in controlling different aspects of defensive behaviors and provided novel insights for investigating defense from the electrophysiological perspective. | Botao Lu Penghui Fan Ming Li Yiding Wang Wei Liang Gucheng Yang Fan Mo Zhaojie Xu Jin Shan Yilin Song Juntao Liu Yirong Wu Xinxia Cai | 2023 | Microsystems & Nanoengineering2023，9，3： | 0 |
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