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| 1 | Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis显示文摘Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders,including COVID-19.However,there are still no effective drugs to treat lung injury and fibrosis.In this study,we report the generation of clinical-grade human embryonic stem cells(hESCs)-derived immunity-and matrix-regulatory cells(IMRCs)produced under good manufacturing practice requirements,that can treat lung injury and fibrosis in vivo.We generate IMRCs by sequentially differentiating hESCs with serum-free reagents.IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells(UCMSCs),such as higher expression levels of proliferative,immunomodulatory and anti-fibrotic genes.Moreover,intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury,and significantly improves the survival rate of the recipient mice in a dose-dependent manner,likely through paracrine regulatory mechanisms.IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone,with an excellent efficacy and safety profile in mice and monkeys.In light of public health crises involving pneumonia,acute lung injury and acute respiratory distress syndrome,our findings suggest that IMRCs are ready for clinical trials on lung disorders. | Jun Wu Dingyun Song Zhongwen Li Baojie Guo Yani Xiao Wenjing Liu Lingmin Liang Chunjing Feng Tingting Gao Yanxia Chen Ying Li Zai Wang Jianyan Wen Shengnan Yang Peipei Liu Lei Wang Yukai Wang Liang Peng Glyn Nigel Stacey Zheng Hu Guihai Feng Wei Li Yan Huo Ronghua Jin Ng Shyh-Chang Qi Zhou Liu Wang Baoyang Hu Huaping Dai Jie Hao | 2020 | Cell Research2020，30，9： | 7 |
| 2 | Atomistic insight into ordered defect superstructures at novel grain boundaries in CuO nanosheets: From structures to electronic properties显示文摘Determining atomistic structures of grain boundaries (GBs) is essential to understand structure--property interplay in oxides.Here,different GB superstructures in CuO nanosheets,including (111) and (114) twinning boundaries (TBs) and (002)/(223) GB,are investigated.Unlike the lower-energy stoichiometric (111) TB,both experimental and first-principles investigations reveal a severe segregation of Cu and O vacancies and a nonstoichiometric property at (114) TB,which may facilitate ionic transportation and provide space for elemental segregation.More importantly,the calculated electronic structures have shown the increased conductivity as well as the unanticipated magnetism in both (114) TB and (002)/(223) GB.These findings could contribute to the race towards the property-directing structural design by GB engineering. | Lulu Zhao Lei Li Huaping Sheng He Zheng Shuangfeng Jia Weiwei Meng Huihui Liu Fan Cao Huayu Peng Jianbo Wang | 2019 | Nano Research2019，12，5： | 5 |
| 3 | Porous surfur-doped hard carbon for excellent potassium storage显示文摘Hard carbon is promising anode for potassium-ion batteries(PIBs),however,the poor rate capability hinders its development as potential anode.To address this question,we design a sulfur-doped porous hard carbon(S-HC)for PIBs through the combination of structural design and composition adjustment.The as-designed S-HC exhibits a long cycling life with^191 mAh/g after 300 cycles at 1 A/g,and an excellent rate capability with^100 mAh/g at 5 A/g,which was attributed to its structural characteristics and compositions.The S-HC demonstrates to be promising anode in the future. | Xuan Xie Shihan Qi Daxiong Wu Huaping Wang Fang Li Xiaoxin Peng Jinfeng Cai Jiaojiao Liang Jianmin Ma | 2020 | Chinese Chemical Letters2020，31，1： | 4 |
| 4 | Target-triggered inhibiting oxidase-mimicking activity of platinum nanoparticles for ultrasensitive colorimetric detection of silver ion显示文摘The development of efficient methods for the detection of hazardous and toxic elements is extremely important for environmental security and public health. In this work, we developed a facile colorimetric assaying system for Ag+ detection in aqueous solution. Chitosan-stabilized platinum nanoparticles(ChPtNPs) were synthesized and severed as an artificial oxidase to catalyze the oxidation of the substrate3,30,5,50-tetramethylbenzidine(TMB) and generate color signal. In the presence of Ag+, due to the strong metallophilic interactions between Ag+ and Pt2+ on the surface of Ch-PtNPs, Ag+ can weaken the affinity to the substrates and inactivate the catalytic activity of Ch-PtNPs, leading to decreased absorbance signal to varying degrees depending on Ag+ amount. Combing the specific binding between Ch-PtNPs and Ag+ with signal amplification procedure based on the Ch-PtNPs-catalyzed TMB oxidation, a sensitive,selective, simple, cost-effective, and rapid detection method for Ag+ can be realized. Ag+ ions in tap and lake waters have been successfully detected. We ensured that the proposed method can be a potential alternative for Ag+ determination in environmental samples. | Haohua Deng Shaobin He Xiuling Lin Lu Yang Zhen Lin Ruiting Chen Huaping Peng Wei Chen | 2019 | Chinese Chemical Letters2019，30，9： | 3 |
| 5 | Removal of humic substances from landfill leachate by Fenton oxidation and coagulation显示文摘 | Yanyu Wu Shaoqi Zhou Fanghui Qin Huaping Peng Yanglan Lai Yiming Lin | 2010 | Process Safety and Environmental Protection2010，，4： | 2 |
| 6 | Ferrocene-modified Fe3O4@SiO 2magnetic nanoparticles as building blocks for construction of reagentless enzyme-based biosensors显示文摘 | Qiu Jianding Peng Huaping Liang Ruping | 2007 | Electrochemistry Communications2007，9，11： | 1 |
| 7 | Ferrocene-Modified Fe3O4@SiO2 Magnetic Nanoparticles as Building Blocks for Construction of Reagentless Enzyme-Based Biosensors显示文摘 | Qiu Jianding Peng Huaping Liang Ruping | 2007 | Electrochem Commun2007，9，： | 1 |
| 8 | A novel nanocomposite matrix based on graphene oxide and ferrocene-branched organically modified sol-gel/chitosan for biosensor application显示文摘 | Peng Huaping Huang Zhengjun Zheng Yanjie | 2014 | Journal of Solid State Electrochemistry2014，18，： | 1 |
| 9 | Ferrocenemodified Fe304 @ Si02 : Magnetic nanoparticles as building blocks for construetion of reagentless enzyme-based biosensors显示文摘 | Qiu Iianding Peng Huaping Liang Ruping | 2007 | Eletrochem Commun2007，9，1： | 1 |
| 10 | Label-free electrochemical immunosensor based on multi-functional gold nanoparticles-polydopamine-thionine-graphene oxide nanocomposites film for determination of alpha-fetoprotein显示文摘 | Peng Huaping Hu Yan Liu AiL in | 2014 | Journal of Electroanalytical Chemistry2014，712，1： | 1 |
| 11 | Facile preparation of novel core-shell enzyme-Au-polydopa mine- Fe3O4 magnetic bionanoparticles for glucose sensor显示文摘 | PENG Huaping LIANG Ruping ZHANG Li | 2013 | Biosensors and Bioelectronics2013，42，： | 1 |
| 12 | Synthesis and characteristics of thermoplastic elastomer based on polyam ide-6显示文摘 | Chunwang Yi Zhihan Peng Huaping Wang | 2011 | Society of Chemical Industry2011，60，12： | 1 |
| 13 | Comparison of Single-Step and Two-Step EBL T-Gates Fabrication Techniques for In P-Based HEMT显示文摘T-Gate fabrication processes for In P-based High electron mobility transistors(HEMTs) are described using PMMA/Al/UVIII. The single-step and two-step Electron beam lithography(EBL) methods are proposed contrastively without dielectric support layer. The optimal gate-foot length is 196 nm for 50 nm geometry path by single-step EBL technique. Since the gate-foot and gate-head are defined independently, the two-step EBL process minimizes forward scattering and enables smaller gate-foot length, which improves to be 141 nm for 50 nm geometry path and also 88 nm for 30 nm geometry path.Both EBL methods have been incorporated into In Pbased HEMTs fabrication. With the gate-foot length decreases from 196 nm to 141 nm, the current-gain cutoff frequency(fT) is improved from 125 GHz to 164 GHz, and also the maximum oscillation frequency(fmax) increases from305 GHz to 375 GHz. | ZHONG Yinghui ZANG Huaping SUN Shuxiang WANG Haili LI Kaikai LI Xinjian DING Peng JIN Zhi | 2016 | Chinese Journal of Electronics2016，25，2： | 0 |
| 14 | Control Effect of UAV Low Volume Spray Technology on Thrips and Tomato Spotted Wilt Virus in Tobacco Field显示文摘[Objectives]The paper was to explore the influence of unmanned aerial vehicle(UAV)low volume spray technology on the control effect of viruliferous thrips and tomato spotted wilt virus(TSWV)under different pesticide concentrations,and to explore the effective control nodes and methods of thrips and TSWV.[Methods]According to the occurrence characteristics of thrips and TSWV,the field control effects of 4 pesticides on thrips and TSWV were tested by UAV with the thrips number and disease index as indicators,following the principle of regional and periodic control trials.[Results]In the groups of UAV and artificial prevention and control,4 agents were used alternatively,including 1%emamectin benzoate ME,1.7%abamectin imidacloprid ME,5%emamectin benzoate WDG,and 30%pyriproxyfen dinotefuran SL.There was no significant difference in the control effect of thrips and TSWV among treatment 1(recommended dosage of UAV agent),treatment 2(reduction of recommended dosage of UAV agent by 25%)and treatment 4(recommended dosage of artificial control agent),and the control effects on thrips were more than 83.16%in the 3 treatments.The disease index of TSWV in the 3 treatments decreased from 8.64±1.37 in the blank control group to less than 3,which reached the prevention and control threshold.But treatment 3(reduction of recommended dosage of UAV agent by 50%)did not reach the prevention and control threshold.The disease index of TSWV in the blank control area increased with the increase of the number of live nymphs of thrips,and there was a significant positive correlation,with good fitness.[Conclusions]UAV has a significant impact on the control effect of thrips and TSWV under different pesticide concentrations.In the actual flight control application,it is recommended that the amount of the pesticides is about 3/4 and not less than 1/2 of that of the artificial application.The control area should be extended to 100 m of the ridge of the tobacco field,and UAV is used periodically to control thrips and TSWV for 5 times from pre-transplanting stage to pre-squaring stage of flue-cured tobacco.The control effect is significantly different from the traditional artificial application. | Zefan LIU Dean XIE Jiabao HAN Yanfen XIE Li MA Siyuan GAO Ruiqi PENG Yuting ZHAO Xiangze FU Wengang CHENG Yonghong FENG Yan ZHANG Huaping ZHANG Ying HUANG Leijie DAI Lanfeng WANG | 2023 | Plant Diseases and Pests2023，14，4： | 0 |
| 15 | T-Gate Fabrication of InP-Based HEMTs Using PMGI/ZEP520A/PMGI/ZEP520A Stacked Resist显示文摘PMGI/ZEP520A/PMGI/ZEP520 A fourlayer resist stack is firstly proposed for T-gates fabrication of InP-based High electron mobility transistors(HEMTs).Gate-head and gate-foot are exposed in single-step Electron beam lithography(EBL), which avoids alignment deviation by automatic self-alignment. The newly introduced PMGI at the bottom greatly improves the adhesiveness of ZEP520 A resist with the substrate. The optimal gate-foot length reaches 101 nm for a design of 50 nm gate footprint pattern, and which can be improved to be 66.8nm for 30 nm gate footprint pattern. Finally, Tgates in nanometer regime have been successfully incorporated into InP-based HEMTs fabrication. Benefiting from both the narrow gate-foot and the reduced parasitic gatecapacitance by single-step EBL technique with the fourlayer resist stack, the fabricated devices with gate-foot length of 101 nm demonstrate excellent DC and RF performances: the maximum extrinsic transconductance, the current-gain cutoff frequency and maximum oscillation frequency are 1051 m S/mm, 249 GHz and 415 GHz, respectively. | ZHONG Yinghui ZANG Huaping WANG Haili SUN Shuxiang LI Kaikai DING Peng JIN Zhi | 2016 | Chinese Journal of Electronics2016，25，3： | 0 |
| 16 | Diselenide as a Dual Functional Mechanophore Capable of Stress Self-Reporting and Self-Strengthening in Polyurethane Elastomers显示文摘Unlike biological materials that can sense mechanical force and actively remodel locally,synthetic polymers typically break down under stress.Molecular-level responses to damage with both stress-reporting and self-strengthening functions are significant yet difficult to realize for synthetic polymers.To overcome this challenge,chemo-mechanical coupling into polymers that can simultaneously ameliorate mechanical,optical,or other functional properties of a polymer combined with mechanical treatment will offer a new principle for materials design.Here,we report a kind of elastomer in which destructive forces are channelled into productive and bond-forming reactions by using diselenide(Se–Se)as a mechanophore.Polyurethane has been functionalized with labile Se–Se bonds,whosemechanical activation generates seleno radicals that trigger radical transfer and cross-linking reactions in situ.These reactions are activated efficiently in a mechanical way by compression in bulk materials.The resulting covalent networks possess turn-on mechano-fluorescence and increased moduli,which provide the functions of stress reporting,mechano-healing,and mechano-remodeling for the deformed film.This study not only illuminates themechano-responsive nature of Se–Se bonds in the bulk state but also paves the way for the development of new stress-responsive materials. | Xiaopei Li Fan Yang Yiran Li Cheng Liu Peng Zhao Yi Cao Huaping Xu Yulan Chen | 2023 | CCS Chemistry2023，5，4： | 0 |
| 17 | A Testing Method for Ratio Restraint Characteristics of Differential Relay Protection of Transformers显示文摘In this paper, a method to calculate the slope of the ratio restraint characteristic of a transformer differential relay protection is proposed. The method allows using some concise but effective means to get the slope. Modulating the argument of current output from ONLLY testing equipment can make the relay protection device operate, thus, the data used for calculation would be obtained naturally after several trails. In order to make sure how effective that method could be, some experiment data is given as well. | Cao Zhihui Peng Chunyan Zhou Huaping | 2012 | Electricity2012，23，5： | 0 |
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