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| 1 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 2 | Prognostic nutritional index is an independent prognostic factor for gastric cancer patients with peritoneal dissemination显示文摘Objective: The predictive and prognostic role of prognostic nutritional index(PNI) in gastric cancer patients with peritoneal dissemination remains unclear. This study aims to explore the role of the PNI in predicting outcomes of gastric cancer patients with peritoneal dissemination.Methods: A total of 660 patients diagnosed with gastric adenocarcinoma with peritoneal metastasis between January 2000 and April 2014 at Sun Yat-sen University Cancer Center and the Sixth Affiliated Hospital of Sun Yatsen University were retrospectively analyzed. The clinicopathologic characteristics and clinical outcomes of patients with peritoneal dissemination were analyzed.Results: Compared with PNI-high group, PNI-low group was correlated with advanced age(P=0.036), worse performance status(P<0.001), higher frequency of ascites(P<0.001) and higher frequency of multisite distant metastasis(P<0.001). Kaplan-Meier survival curves showed that PNI-high group had a significantly longer median overall survival than PNI-low group(13.13 vs. 9.03 months, P<0.001). Multivariate survival analysis revealed that Borrmann type IV(P=0.014), presence of ascites(P=0.017) and lower PNI(P=0.041) were independent poor prognostic factors, and palliative surgery(P<0.001) and first-line chemotherapy(P<0.001) were good prognostic factors. For patients receiving palliative surgery, the postoperative morbidity rates in the PNI-low group and PNIhigh group were 9.1% and 9.9%, respectively(P=0.797). The postoperative mortality rate was not significantly different between PNI-low and PNI-high groups(2.3% vs. 0.9%, P=0.362).Conclusions: PNI is a useful and practical tool for evaluating the nutritional status of gastric cancer patients with peritoneal dissemination, and is an independent prognostic factor for these patients. | Runcong Nie Shuqiang Yuan Shi Chen Xiaojiang Chen Yongming Chen Baoyan Zhu Haibo Qiu Zhiwei Zhou Junsheng Peng Yingbo Chen | 2016 | Chinese Journal of Cancer Research2016，28，6： | 19 |
| 3 | Prognostic factors of primary gastrointestinal stromal tumors: a cohort study based on high-volume centers显示文摘Objective: We aimed to evaluate the clinicopathologic characteristics, immunohistochemical expression and prognostic factors of patients with primary gastrointestinal stromal tumors(GISTs).Methods: Data from 2,570 consecutive GIST patients from four medical centers in China(January2001–December 2015) were reviewed. Survival curves were constructed by the Kaplan-Meier method, and Cox regression models were used to identify independent prognostic factors.Results: Of the included patients, 1,375(53.5%) were male, and the patient age range was 18 to 95(median, 58)years. The tumors were mostly found in the stomach(64.5%), small intestine(25.1%) and colorectal region(5.1%).At the time of diagnosis, the median tumor size was 4.0(range: 0.1–55.0) cm, and the median mitotic index per 50 high power fields(HPFs) was 3(range: 0–254). Of the 2,168 resected patients, 2,009(92.7%) received curative resection. According to the modified National Institutes of Health(NIH) classification, 21.9%, 28.9%, 14.1% and35.1% were very low-, low-, intermediate-and high-risk tumors, respectively. The rate of positivity was 96.4% for c-Kit, 87.1% for CD34, 96.9% for delay of germination 1(DOG-1), 8.0% for S-100, 31.0% for smooth muscle actin(SMA) and 5.1% for desmin. However, the prognostic value of each was limited. Multivariate analysis showed that age, tumor size, mitotic index, tumor site, occurrence of curative resection and postoperative imatinib were independent prognostic factors. Furthermore, we found that high-risk patients benefited significantly from postoperative imatinib(P<0.001), whereas intermediate-risk patients did not(P=0.954).Conclusions: Age, tumor size, mitotic index, tumor site, occurrence of curative resection and postoperative imatinib were independent prognostic factors in patients with GISTs. Moreover, determining whether intermediate-risk patients can benefit from adjuvant imatinib would be of considerable interest in future studies. | Xuechao Liu Haibo Qiu Peng Zhang Xingyu Feng Tao Chen Yong Li Kaixiong Tao Guoxin Li Xiaowei Sun Zhiwei Zhou | 2018 | Chinese Journal of Cancer Research2018，30，1： | 14 |
| 4 | Landscape of DILI-related adverse drug reaction in China Mainland显示文摘Drug-induced liver injury(DILI)is a type of bizarre adverse drug reaction(ADR)damaging liver(L-ADR)which may lead to substantial hospitalizations and mortality.Due to the general low incidence,detection of L-ADR remains an unsolved public health challenge.Therefore,we used the data of 6.673 million of ADR reports from January 1st,2012 to December 31st,2016 in China National ADR Monitoring System to establish a new database of L-ADR reports for future investigation.Results showed that totally 114,357 ADR reports were retrieved by keywords searching of liver-related injuries from the original heterogeneous system.By cleaning and standardizing the data fields by the dictionary of synonyms and English translation,we resulted 94,593 ADR records reported to liver injury and then created a new database ready for computer mining.The reporting status of L-ADR showed a persistent 1.62-fold change over the past five years.The national population-adjusted reporting numbers of L-ADR manifested an upward trend with age increasing and more evident in men.The annual reporting rate of L-ADR in age group over 80 years old strikingly exceeded the annual DILI incidence rate in general population,despite known underreporting situation in spontaneous ADR reporting system.The percentage of herbal and traditional medicines(H/TM)L-ADR reports in the whole number was 4.5%,while 80.60%of the H/TM reports were new findings.There was great geographical disparity of reported agents,i.e.more cardiovascular and antineoplastic agents were reported in higher socio-demographic index(SDI)regions and more antimicrobials,especially antitubercular agents,were reported in lower SDI regions.In conclusion,this study presented a large-scale,unbiased,unified,and computer-minable L-ADR database for further investigation.Age-,sex-and SDI-related risks of L-ADR incidence warrant to emphasize the precise pharmacovigilance policies within China or other regions in the world. | Jiabo Wang Haibo Song Feilin Ge Peng Xiong Jing Jing Tingting He Yuming Guo Zhuo Shi Chao Zhou Zixin Han Yanzhong Han Ming Niu Zhaofang Bai Guangbin Luo Chuanyong Shen Xiaohe Xiao | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 12 |
| 5 | Virtual reality-based rehabilitation in patients following total knee arthroplasty:a systematic review and meta-analysis of randomized controlled trials显示文摘Background:Physical therapy is regarded as an essential aspect in achieving optimal outcomes following total knee arthroplasty(TKA).The coronavirus disease 2019(COVID-19)pandemic has made face-to-face rehabilitation inaccessible.Virtual reality(VR)is increasingly regarded as a potentially effective option for offering health care interventions.This systematic review and meta-analysis investigate VR-based rehabilitation's effectiveness on outcomes following TKA.Methods:From inception to May 22,2021,PubMed/Medline,Embase,Web of Science,the Cochrane Central Register of Controlled Trials,Scopus,PsycINFO,Physiotherapy Evidence Database,China National Knowledge Infrastructure,and Wanfang were comprehensively searched to identify randomized controlled trials(RCTs)evaluating the effect of VR-based rehabilitation on patients following TKA according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and the Cochrane Handbook for Systematic Reviews of Interventions.Results:Eight studies were included in the systematic review,and seven studies were included in the meta-analysis.VR-based rehabilitation significantly improved visual analog scale(VAS)scores within 1 month(standardized mean difference[SMD]:−0.44;95%confidence interval[CI]:−0.79 to−0.08,P=0.02),the Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)within 1 month(SMD:−0.71;95%CI:−1.03 to−0.40,P<0.01),and the Hospital for Special Surgery Knee Score(HSS)within 1 month and between 2 months and 3 months(MD:7.62;95%CI:5.77 to 9.47,P<0.01;MD:10.15;95%CI:8.03 to 12.27,P<0.01;respectively)following TKA compared to conventional rehabilitation.No significant difference was found in terms of the Timed Up and Go(TUG)test.Conclusions:VR-based rehabilitation improved pain and function but not postural control following TKA compared to conventional rehabilitation.More high-quality RCTs are needed to prove the advantage of VR-based rehabilitation.As the COVID-19 pandemic continues,it is necessary to promote this rehabilitation model. | Linbo Peng Yi Zeng Yuangang Wu Haibo Si Bin Shen | 2022 | Chinese Medical Journal2022，，2： | 5 |
| 6 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 7 | Antioxidative stress-induced damage in cochlear explants显示文摘The imbalance of reactive oxygen species and antioxidants is considered to be an important factor in the cellular injury of the inner ear. At present, great attention has been placed on oxidative stress. However,little is known about fighting oxidative stress. In the current study, we evaluated antioxidant-induced cochlear damage by applying several different additional antioxidants. To determine whether excessive antioxidants can cause damage to cochlear cells, we treated cochlear explants with 50 m M M40403, a superoxide dismutase mimetic, 50 m M coenzyme Q-10, a vitamin-like antioxidant, or 50 m M d-methionine, an essential amino acid and the important antioxidant glutathione for 48 h. Control cochlear explants without the antioxidant treatment maintained their normal structures after incubation in the standard serum-free medium for 48 h, indicating the maintenance of the inherent oxidative and antioxidant balance in these cochlear explants. In contrast, M40403 and coenzyme Q-10-treated cochlear explants displayed significant hair cell damage together with slight damage to the auditory nerve fibers.Moreover, d-methiodine-treated explants exhibited severe damage to the surface structure of hair cells and the complete loss of the spiral ganglion neurons and their peripheral fibers. These results indicate that excessive antioxidants are detrimental to cochlear cells, suggesting that inappropriate dosages of antioxidant treatments can interrupt the balance of the inherent oxidative and antioxidant capacity in the cell. | Dalian Ding Jianghui Zhang Fang Liu Peng Li Weidong Qi Yazhi Xing Haibo Shi Haiyan Jiang Hong Sun Shankai Yin Richard Salvi | 2020 | Journal of Otology2020，15，1： | 3 |
| 8 | Essential training steps to achieving competency in the basic intraoperative transesophageal echocardiography examination for Chinese anesthesiologists显示文摘为检查定义的 intraoperative transesophageal echocardiography (T ) 的指南为医药专业人员的一个详细标准,特别地麻醉学者, T 考试怎么应该继续。多年以来, T 获得了实质的流行并且作为一种比较喜欢的监视形式出现了在血液动力学的不稳定性状况或批评照顾背景期间帮助 perioperative 管理和决策。T 训练小径和惯例指南很好在西方的国家和世界的许多区域被建立了。然而, T 为麻醉学者训练和实践信息缺乏中国。当创新技术发展,另外的教育模型出现了帮助在基本 T 考试获得才能。因此,在在中国为麻醉学者训练途径的理想的 T 上建立一致着急地被需要。开发能被合并到居民外套训练也是的麻醉学的有效课程对必要在基本 T 考试向才能提供知识和技巧。与演变,医药系统改革,增加为 intraoperative 要求提供外科的革新的血液动力学的监视,麻醉学专业人员逐渐地被强迫在他们的现在和将来的惯例执行 intraoperative T 考试。克服障碍并且在使用 TEE 形式在 intraoperative 管理和外科的决策帮助获得重要进步,出版为瓷器麻醉学者训练指南的基本 T 是一个重要努力。 | Yong G. Peng Haibo Song E. Wang Weipeng Wang Jin Liu | 2015 | Frontiers of Medicine2015，9，1： | 2 |
| 9 | In situ monitoring of the structural change of microemulsions in simulated gastrointestinal conditions by SAXS and FRET显示文摘Microemulsions are promising drug delivery systems for the oral administration of poorly watersoluble drugs. However, the evolution of microemulsions in the gastrointestinal tract is still poorly characterized,especially the structural change of microemulsions under the effect of lipase and mucus. To better understand the fate of microemulsions in the gastrointestinal tract, we applied small-angle X-ray scattering(SAXS) and fluorescence resonance energy transfer(FRET) to monitor the structural change of microemulsions under the effect of lipolysis and mucus. First, the effect of lipolysis on microemulsions was studied by SAXS, which found the generation of liquid crystalline phases. Meanwhile, FRET spectra indicated micelles with smaller particle sizes were generated during lipolysis, which could be affected by CaCl_2, bile salts and lecithin. Then, the effect of mucus on the structural change of lipolysed microemulsions was studied. The results of SAXS and FRET indicated that the liquid crystalline phases disappeared, and more micelles were generated. In summary, we studied the structural change of microemulsions in simulated gastrointestinal conditions by SAXS and FRET, and successfully monitored the appearance and disappearance of the liquid crystalline phases and micelles. | Xia Lv Shuguang Zhang Huipeng Ma Peipei Dong Xiaodong Ma Ming Xu Yan Tian Zeyao Tang Jinyong Peng Haibo Chen Jianbin Zhang | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 2 |
| 10 | Swarm intelligence for classification of remote sensing data显示文摘This paper proposes a new method to classify remote sensing data by using Particle Swarm Optimization (PSO). This method is to generate classification rules through simulating the behaviors of bird flocking. Optimized intervals of each band are found by particles in multi-dimension space, linked with land use types for forming classification rules. Compared with other rule induction techniques (e.g. See5.0), PSO can efficiently find optimized cut points of each band, and have good convergence in the search process. This method has been applied to the classification of remote sensing data in Panyu district of Guangzhou with satisfactory results. It can produce higher accuracy in the classification than the See5.0 decision tree model. | Liu XiaoPing Li Xia Peng XiaoJuan Li HaiBo He JinQiang | 2008 | Science China Earth Sciences2008，51，1： | 2 |
| 11 | Long Term Sea Level Change and Water Mass Balance in the South China Sea显示文摘Sea level anomalies observed by altimeter during the 1993–2006 period, thermosteric sea level anomalies estimated by using subsurface temperature data produced by Ishii and SODA reanalysis data, tide gauge records and HOAPS freshwater flux data were analyzed to investigate the long term sea level change and the water mass balance in the South China Sea. The altimeter-observed sea level showed a rising rate of (3.5±0.9) mm yr-1 during the period 1993–2006, but this figure was considered to have been highly distorted by the relatively short time interval and the large inter-decadal variability, which apparently exists in both the thermosteric sea level and the observed sea level. Long term thermosteric sea level from 1945 to 2004 gave a rising rate of 0.15±0.06 mm yr-1. Tide gauge data revealed this discrepancy and the regional distributions of the sea-level trends. Both the ‘real’ and the thermosteric sea level showed a good correspondence to ENSO: decreasing during El Nio years and increasing during La Nia years. Amplitude and phase differences between the ‘real’ sea level and the thermosteic sea level were substantially revealed on both seasonal and interannual time scales. As one of the possible factors, the freshwater flux might play an important role in balancing the water mass. | RONG Zengrui LIU Yuguang ZONG Haibo XIU Peng | 2009 | Journal of Ocean University of China2009，8，4： | 2 |
| 12 | Facet-dependent electrochemiluminescence spectrum of nanostructured ZnO显示文摘A facet-dependent electrochemiluminescence (ECL) behavior was found for nanostructured ZnO with different dominant exposing planes.The ECL spectrum of nanostructured ZnO was recorded by the emission scan mode with a fluorescence spectrometer and applied to investigate the difference of surface state for different crystal planes.Electronic structure calculations based on density functional theory were used to study the effect of crystal plane on the band structure and density of states.It revealed that the ECL emission was originated primarily from the recombination of electrons from Zn 4s and the hole from O 2p,which could be utilized to study the physical and chemical properties of surface structures of as-prepared nanostructured ZnO.A physical model was suggested to elucidate the differences of ECL spectra.A concept was proposed that the energy released as photons during ECL process of nanocrystalline semiconductor materials will be correlated with the energy level of active sites located at different crystal planes. | WANG Lei YUE QiaoLi LI HaiBo XU ShuLing GUO LianShun ZHANG XianXi WANG HuaiSheng GAO XueXi WANG WenJun LIU JiFeng LIU Peng | 2013 | Science China Chemistry2013，56，1： | 2 |
| 13 | The Active Sites and Corresponding Stability Challenges of the M-N-C Catalysts for Proton Exchange Membrane Fuel Cell显示文摘Proton exchange membrane fuel cells(PEMFCs)as promising alternatives to traditional internal combustion engines have attracted massive concerns to promote their wide application in society.However,the biggest challenge to the commercialization of PEMFCs remains the high cost due to the adoption of the platinum group metal(PGM)catalysts in the cathode. | Ruolin Peng Zhongkun Zhao Hongmin Sun Yongping Yang Tinglu Song Yao Yang Jiankun Shao Haibo Jin Hongtao Sun Zipeng Zhao | 2023 | Chinese Journal of Chemistry2023，41，6： | 1 |
| 14 | Synthesis of LiNi 1/3 Co 1/3 Mn 1/3 O 2 as a cathode material for lithium battery by the rheological phase method显示文摘 | Haibo Ren Yourong Wang Daocong Li Lihua Ren Zhenghe Peng Yunhong Zhou | 2008 | Journal of Power Sources2008，，1： | 1 |
| 15 | Preparation of Lanthana-doped titania nanoparticles with anatase mesoporous walls and high photocatalytic activity显示文摘 | Tianyou Peng De Zhao Haibo Song | 2005 | Journal of Molecular Catalysis A: Chemical2005，238，12： | 1 |
| 16 | Structural dynamic analysis of the orbiting scroll wrap in the scroll compressor显示文摘 | Yicai LIU Yubo XIA Peng YAN Yinbin LI Haibo XIE | 2013 | Frontiers in Energy2013，7，1： | 1 |
| 17 | Research on the Process Layer and Substation Layer Relay Protection in Smart Substation Relay Protection显示文摘The intelligent substation relay protection facility is a fundamental element in construction of modern power system,based on the principles of flexibility,security and accuracy,and it can be divided into process layer and substation layer according to specific equipment.The former is suitable for individual sampling of disposable equipment,can be separated from the base station synchronization sampling,with the help of synchronous digital system and ping-pong algorithm to achieve synchronization of the overall sampling,that is to take the distribution protection components,through the separate transmission medium to realize the information transmission;the latter is for variable power plant components centralized backup protection,taking online real-time tuning technique. | Kong Haibo Xie Xiaodong Wang Lingfei Sun Peng Xu Bing | 2018 | Journal of Electronic Research and Application2018，2，1： | 1 |
| 18 | A simple and reusable fluorescent sensor for heme proteins based on a conjugated polymer-doped electrospun nanofibrous membrane显示文摘 | Huaming Wang Zhou Peng Yuanyuan Long Haibo Chen Yufei Yang Na Li Feng Liu | 2012 | Talanta2012，，： | 1 |
| 19 | Rabbit Sera Containing Compound Danshen Dripping Pill Attenuate Leukocytes Adhesion to TNF-Alpha–Activated Human Umbilical Vein Endothelial Cells by Suppressing Endothelial ICAM-1 and VCAM-1 Expression Through NF-KappaB Signaling Pathway显示文摘 | Haibo Xu Dejian Wang Cheng Peng Xiushen Huang Ming Ou Ningsheng Wang Peixun Wang Lijuan Zhou Xiaolin Ye | 2014 | Journal of Cardiovascular Pharmacology2014，，4： | 1 |
| 20 | A Method for Assessing the Fairness of Health Resource Allocation Based on Geographical Grid显示文摘The assessment of the fairness of health resource allocation is an important part of the study for the fairness of social development.The data used in most of the existing assessment methods comes from statistical yearbooks or field survey sampling.These statistics are generally based on administrative areas and are difficult to support a fine-grained evaluation model.In response to these problems,the evaluation method proposed in this paper is based on the query statistics of the geographic grid of the target area,which are more accurate and efficient.Based on the query statistics of hot words in the geographic grids,this paper adopts the maximum likelihood estimation method to estimate the population in the grid region.Then,according to the statistical yearbook data of Hunan province,the estimated number and actual number of hospitals in each grid are analyzed and compared to measure the fairness of health resource allocation in the target region.Experiments show that the geographical grid population assessment based on hot words is more accurate and close to the actual value.The estimated average error is only about 17.8 percent.This method can assess the fairness of health resource allocation in any scale,and is innovative in data acquisition and evaluation methods. | Jin Han Wenhao Jiang Jin Shi Sun Xin Jin Peng Haibo Liu | 2020 | Computers, Materials & Continua2020，，8： | 1 |
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