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| 1 | Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets显示文摘Hepatocellular 癌(HCC ) 每年是为 500 000 死亡负责的世界范围的一个主要健康问题。很多个风险因素与也被联系疾病或它的前进的正式就职;这些与肝炎 B 或 C 病毒,白酒消费,非酒精的 steatohepatitis 和某些先天的混乱包括感染。在约 80% 盒子, HCC 与肝硬化或先进纤维变性并且与发炎和氧化应力被联系。在这评论,我们为 HCC 第一集中于不同风险因素并且总结由哪个各被认为贡献 HCC 的机制。在第二部分,我们看涉及癌症前进的分子的过程。HCC 开发作为 multistep 进程被认出通常在许多年发展。在几个变化在房间和那积累的这个时期上刺激诽谤转变,生长,和变形行为。在最近的年,不仅肿瘤房间本身而且肿瘤 microenviroment 在一个肿瘤的发展起一个主要作用,变得明显。与这 microenviroment 在发炎和肝硬化的角色之间有一个直接连接。在 vitro 并且在 vivo,它被看了那肿瘤形成,变形性质被连接到上皮间充质的转变(EMT ) ,由 facillitates,肿瘤房间是尝试移居到更赞成的 microenviroment 的一个过程。几个组由 microarray 在 HCC 和它的包围织物分析了基因表示,这导致了分子的分类进班的一个不同数字。这里,我们也发现为组织缺氧的一个角色导致了基因表示导致一临床上在 HCC 的更好攻击的基因表示。分子的分析也帮助识别重要细胞的小径和可能的治疗学的目标。这样为肝癌症显示出临床的申请的第一个分子是 multikinase 禁止者 sorafenib,其它当前在象 mTOR 禁止者 everolimus 一样的临床的研究的不同阶段。 | Tamara SEVERI Hannah van MALENSTEIN Chris VERSLYPE Jos F van PELT | 2010 | Acta Pharmacologica Sinica2010，31，11： | 23 |
| 2 | The Soil-Borne Identity and Microbiome-Assisted Agriculture:Looking Back to the Future显示文摘Looking forward includes looking back every now and then.In 2007,David Weller looked back at 30 years of biocontrol of soil-borne pathogens by Pseudomonas and signified that the progress made over decades of research has provided a firm foundation to formulate current and future research questions.It has been recognized for more than a century that soil-borne microbes play a significant role in plant growth and health.The recent application of high-throughput omics technologies has enabled detailed dissection of the microbial players and molecular mechanisms involved in the complex interactions in plant-associated microbiomes.Here,we highlight old and emerging plant microbiome concepts related to plant disease control,and address perspectives that modern and emerging microbiomics technologies can bring to functionally characterize and exploit plant-associated microbiomes for the benefit of plant health in future microbiome-assisted agriculture. | Peter A.H.M.Bakker Roeland L.Berendsen Johan A.Van Pelt Gilles Vismans Ke Yu Erqin Li Sietske Van Bentum Sanne W.M.Poppeliers Juan J.Sanchez Gil Hao Zhang Pim Goossens Ioannis A.Stringlis Yang Song Ronnie de Jonge CornéM.J.Pieterse | 2020 | Molecular Plant2020，13，10： | 3 |
| 3 | Presence of a high amount of stroma and downregulation of SMAD4 predict for worse survival for stage I–II colon cancer patients显示文摘 | Wilma E. Mesker Gerrit-Jan Liefers Jan M.C. Junggeburt Gabi W. van Pelt Paola Alberici Peter J.K. Kuppen Noel F. Miranda Karin A.M. van Leeuwen Hans Morreau Karoly Szuhai Rob A.E.M. Tollenaar Hans J. Tanke | 2009 | Cellular Oncology2009，，3： | 2 |
| 4 | The Metabolic Syndrome显示文摘 | Marc-Andre Cornier Dana Dabelea Teri L. Hernandez Rachel C. Lindstrom Amy J. Steig Nicole R. Stob Rachael E. Van Pelt Hong Wang Robert H. Eckel | 2008 | Endocrine Reviews2008，，7： | 2 |
| 5 | Rectal washout with cytotoxic solution can be extended to the whole colon显示文摘 | P. P.Mariani J. F.van Pelt N.Ectors B.Topal A.D’Hoore F.Penninckx | 2002 | Br J Surg2002，，12： | 2 |
| 6 | Enhancement of induced disease resistance by simultaneous activation of salicylate-and jasmonate-dependent defense pathways in Arabidopsis thaliana 显示文摘 | van Wees S C de Swart E A van Pelt J A | 2000 | PNAS2000，97，： | 2 |
| 7 | Transitios cell hyperplasia and Carcinomas in urinary bladders of transgeanic mice with kcratin 5 promoter-driven cyclooxygenase-2 overexpression 显示文摘 | Klein R D Van Pelt C S Sabichi AL | 2005 | Cancer Res2005，65，5： | 1 |
| 8 | Stimulation of reactive oxygen species and collagen synthesis by angiotensin II in cardiac fibroblasts显示文摘 | Lijnen PJ Pelt JF Fagard RH | 2010 | Cardiovasc Ther2010，8，7： | 1 |
| 9 | Effects of high dose Ⅳ pamidronate on disease activity and bone metabolism in patients with active RA : a randomized, double - blind, placebo - controlled trial 显示文摘 | Lodder MC Van Pelt PA Lems WF | 2003 | J Rheumatol2003，30，： | 1 |
| 10 | Effect of three differ- ent anaesthetic agents on the post-operative production of cardiac troponin T in paediatfic cardiac surgery显示文摘 | Malagon I Hogenhirk K van Pelt J | 2005 | Br J Anaesth2005，94，6： | 1 |
| 11 | Serum biomarkers for experimental acute spinal cord injury: rapid elevation of neuronspecific enolase and S-100beta显示文摘 | Loy DN Sroufe AE Pelt JL | 2005 | Neurosurgery2005，56，2： | 1 |
| 12 | A Large- Scale RNAi Screen Identifies Deaf1 as a Regulator of Innate Immune Responses in Drosophila显示文摘 | Kuttenkeuler D N Pelte M Boutros | 2010 | Journal of Innate Immunity2010，2，2： | 1 |
| 13 | Longitudinal left ven- tricular contractile dysfunction after exercise in aortic stenosis 显示文摘 | Van Pelt NC Stewart RA Legget ME | 2007 | Heart2007，93，6： | 1 |
| 14 | temporal stability of spatially measured soil matric potential probability density function 显示文摘 | Van Pelt R S Wierenga P J | 2001 | Soil SciSocAmJ2001，65，： | 1 |
| 15 | Molecular classification of hepatocellular carcinoma anno 2011显示文摘 | Malenstein H V Pelt J V Verslype C | 2011 | European journal of cancer2011，47，： | 1 |
| 16 | The Metabolic Syndrome显示文摘 | Marc-Andre Cornier Dana Dabelea Teri L. Hernandez Rachel C. Lindstrom Amy J. Steig Nicole R. Stob Rachael E. Van Pelt Hong Wang Robert H. Eckel | 2008 | Endocrine Reviews2008，，7： | 1 |
| 17 | Serum biomarkers for experimental acute spinal cord injury: rapid elevation of neuron- specific enolase and S-100 beta 显示文摘 | Loy DN Sroufe AE Pelt JL | 2005 | Neurosurgery2005，56，2： | 1 |
| 18 | Obesity, insulin resistance, and Alzheimer's disease 显示文摘 | HILDRETH KL van PELT RE SCHWARTA RS | 2012 | Obesity (Silver Spring)2012，20，8： | 1 |
| 19 | Serum biomarkers for experimental acute spinal cord injury:rapid elevation of neuron-specific enolase and S-100beta显示文摘 | Loy DN Sroufe AE Pelt JL | 2005 | Neurosurgery2005，56，： | 1 |
| 20 | Gain-of-function amino acid substitutions drive positive selection of FGFR2 mutations in human spermatogonia显示文摘 | Goriely A McVean GA van Pelt AM | | 0，，： | 1 |
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