| 1 | Cytokeratms and carcinoembryonic antigen in diagnosis,staging and prognosis of colorectal adenocarcinoma显示文摘AIM: To evaluate the serum levels of cytokeratins and carcinoembryonic antigen (CEA) in diagnosis, staging and prognosis of patients with colorectal adenocarcinoma.METHODS: The sample consisted of 169 patients. One hundred blood donors formed the control group. Radical surgery was performed on 120 patients, with an average follow-up duration of 22.3 mo. Relapses occurred in 23individuals after an average of 18.09 mo. CEA was assayed via the Delfia(R) method with a limit of 5 ng/mL. Cytokeratins were assayed via the LIA-mat(R) TPA-M Prolifigen(R) method with a limit of 72 U/L.RESULTS: In the diagnosis of patients with colorectal adenocarcinoma, CEA showed a sensitivity of 56%, a specificity of 95%, a positive predictive value of 94%, a negative predictive value of 50% and an accuracy of 76.8%.TPA-M had a sensitivity of 70%, a specificity of 96%, a positive predictive value of 97%, a negative predictive value of 66% and an accuracy of 93.6%. The elevation of one of the markers was shown to have a sensitivity of 76.9%, a specificity of 91%, a positive predictive value of 93.5%, a negative predictive value of 70% and an accuracy of 83.6%.There was no variation in the levels of the markers according to the degree of cell differentiation while there was an elevation in their concentrations in accordance with the increase in neoplastic dissemination. There was a statistically significant difference between the patients with stage Ⅳ lesions and those with stages Ⅰ, Ⅱ and Ⅲ tumors.With regard to CEA, the averagelevel was 14.2 ng/mL in patients with stage Ⅰ lesions, 8.5 ng/mL in patients with stage Ⅱ lesions, 8.0 ng/mL in patients with stage Ⅲ lesions and 87.7 ng/mL in patients with stage Ⅳ lesions. In relation to TPA-M, the levels were 153.1 U/L in patients with stage Ⅰtumors, 106.5 U/L in patients with stage Ⅱ tumors, 136.3 U/L in patients with stage Ⅲ tumors and 464.3 U/L in patients with stage Ⅳ tumors. There was a statistical difference in patients with a high CEA level in relation to a shorter survival(P<0.05). However, there was no correlation between patients with high TPA-M levels and prognostic indices of patients undergoing radical surgery.CONCLUSION: Cytokeratins demonstrate a greater sensitivity than CEA in the diagnosis of colorectal adenocarcinoma.There is an increase in the sensitivity of the markers with tumor dissemination. Cytokeratins cannot identify the worse prognosis in patients undergoing radical surgery.Cytokeratins constitute an advance in the direction of a perfect tumor marker in the treatment of patients with colorectal cancer. | Luís C.Fernandes Su B.Kim Delcio Matos | 2005 | World Journal of Gastroenterology2005，11，5： | 21 |
| 4 | Breeding for drought tolerance in perennial ryegrass(Lolium perenne L.)and tall fescue(Lolium arundinaceum[Schreb.]Darbysh.)by exploring genotype by environment by management interactions显示文摘Background:Drought‐tolerant turfgrass cultivars are becoming more important each year as landscape irrigation practices are becoming more restrictive.Methods:In this study,we quantified the level of drought tolerance(DT)in perennial ryegrass and tall fescue genotypes across years under different mowing(MH)and fertility(FL)rates.A total of 48 ryegrass and 38 tall fescue genotypes were planted in 2011 at NexGen,Albany,OR.The trial was divided into three subtrials:(i)DT;(ii)MH and DT;and(iii)FL and DT.Results:The results showed that there was significant genetic variance for most of the traits in both species.The genotype×year interaction was predominantly simple,indicating small changes in genotype ranking for both species.Lower MH improved DT in perennial ryegrass,whereas higher MH resulted in greater DT in tall fescue.For both species,higher MH improved the population mean for turf quality.Higher FL inputs led to higher turf quality for both species,but it did not affect the DT response.Conclusions:Using a selection index,six genotypes for perennial ryegrass and four for tall fescue were selected. | Claudio C.Fernandes Filho Mario H.Murad Leite Andrade Jose A.Rodrigues Nunes Joseph Wipff Debra L.Hignight Esteban F.Rios Kevin Kenworthy Kenneth Hignight | 2023 | Grassland Research2023，2，1： | 0 |
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