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| 1 | Toward New-Generation Intelligent Manufacturing显示文摘 | Zhou Ji Li Peigen Zhou Yanhong Wang Baicun Zang Jiyuan Meng Liu | 2018 | Engineering2018，4，1： | 224 |
| 2 | De novo characterization of the root transcriptome of a traditional Chinese medicinal plant Polygonum cuspidatum显示文摘Various active components have been extracted from the root of Polygonum cuspidatum.However,the genetic basis for their activity is virtually unknown.In this study,25600002 short reads (2.3 Gb) of P.cuspidatum root transcriptome were obtained via Illumina HiSeq 2000 sequencing.A total of 86418 unigenes were assembled de novo and annotated.Twelve,18,60 and 54 unigenes were respectively mapped to the mevalonic acid (MVA),methyl-D-erythritol 4-phosphate (MEP),shikimate and resveratrol biosynthesis pathways,suggesting that they are involved in the biosynthesis of pharmaceutically important anthraquinone and resveratrol.Eighteen potential UDP-glycosyltransferase unigenes were identified as the candidates most likely to be involved in the biosynthesis of glycosides of secondary metabolites.Identification of relevant genes could be important in eventually increasing the yields of the medicinally useful constituents of the P.cuspidatum root.From the previously published transcriptome data of 19 non-model plant taxa,1127 shared orthologs were identified and characterized.This information will be very useful for future functional,phylogenetic and evolutionary studies of these plants. | HAO DaCheng MA Pei MU Jun CHEN ShiLin XIAO PeiGen PENG Yong HUO Li XU LiJia SUN Chao | 2012 | Science China(Life Sciences)2012，55，5： | 36 |
| 3 | Chemical and biological research of Clematis medicinal resources显示文摘Clematis is a botanical source for various pharmaceutically active components,which has long been used in conventional medicine since the beginning of Chinese civilization.Increasing interest in Clematis medicinal resources has led to additional discoveries of triterpenoid saponins,flavonoids,coumarins,alkaloids and many other compounds in various Clematis species,and to investigations on their chemotaxonomy,molecular phylogeny and pharmacology.In continuation with our studies on Clematis chemistry and biology,we review the chemistry,chemotaxonomy,molecular biology and phylogeny of Clematis and their relevance to drug efficacy and drug development.Various databases and technology have been used in literature search in order to characterize the global scientific effort.It is essential to study more species for both the sustainable utilization of Clematis medicinal resources and finding novel compounds with potential clinical utility.Systems biology and omics technologies will play an increasingly important role in future medicinal research involving bioactive compounds of Clematis. | HAO DaCheng GU XiaoJie XIAO PeiGen PENG Yong | 2013 | Chinese Science Bulletin2013，58，10： | 13 |
| 4 | Serum IgA,IgM,and IgG responses in COVID-19显示文摘Currently,detecting SARS-CoV-2 RNAs is a standard approach for COVID-19 diagnosis.However,there is an urgent need for reliable and rapid serological diagnostic methods to screen SARS-CoV-2-infected people including those who do not have overt symptoms.Most emerging studies described serological tests based on detection of SARS-CoV-2-specific IgM and IgG.1–4 Although detection of SARS-CoV-2-specific IgA in serum has been reported in few papers,5,6 analyses of IgA levels in a larger number of COVID-19 patients are still lacking. | Huan Ma Weihong Zeng Hongliang He Dan Zhao Dehua Jiang Peigen Zhou Linzhao Cheng Yajuan Li Xiaoling Ma Tengchuan Jin | 2020 | Cellular & Molecular Immunology2020，17，7： | 12 |
| 5 | Study on the morphology, crystalline structure and thermal properties of yam starch acetates with different degrees of substitution显示文摘This study was carried out to understand and establish the changes in physicochemical properties of starch extracted from Chinese yam (Dioscorea opposita Thunb.) after acetylation. Yam starch acetates with different degrees of substitution (DS) were prepared by the reaction of yam starch with glacial acetic acid/acetic anhydride using sulfuric acid as the catalyst. Their formation was confirmed by the presence of the carbonyl signal around 1750 cm-1 in the Fourier transform infrared (FT-IR) spectra. The thermal behavior of the native starch and starch acetate were investigated using thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The results reveal that the starch acetates are more thermally stable than the native starch. The starch esters showed 50% weight loss at tem- peratures from 328℃ to 372 ℃ , while the native starch underwent 50% weight loss at 325℃ . The glass transition temperature (Tg) of the starch decreased from 273℃ to 226℃. The X-ray diffraction (XRD) patterns could be classified as typical of the C-type for yam starch. X-ray diffraction also showed the loss of the ordered C-type starch crystalline structure and the degree of crystallinity of starch de- creased from 36.10% to 10.96% with the increasing DS. The scanning electron microscopy (SEM) sug- gested that the most of the starch granules disintegrated with many visible fragments with the in- creasing DS. | WANG Xu GAO WenYuan ZHANG LiMing XIAO PeiGen YAO LiPing LIU Yi LI KeFeng XIE WeiGuang | 2008 | Science China Chemistry2008，51，9： | 11 |
| 6 | Investigation of free amino acid, total phenolics,antioxidant activity and purine alkaloids to assess the health properties of non-Camellia tea显示文摘To find novel functional beverages from folk teas, 33 species of frequently used non-Camellia tea(plants other than Camellia) were collected and compared with Camellia tea(green tea, pu-erh tea and black tea) for the first time. Data are reported here on the quantities of 20 free amino acids(FAAs) and three purine alkaloids(measured by UHPLC), total polyphenols(measured by Folin-Ciocalteu assay), and antioxidant activity(DPPH). The total amounts of FAAs in non-Camellia tea(0.62–18.99 mg/g) are generally less than that of Camellia tea(16.55–24.99 mg/g). However, for certain FAAs, the quantities were much higher in some non-Camellia teas, such as γ-aminobutyric acid in teas from Ampelopsis grossedentata, Isodon serra and Hibiscus sabdariffa. Interestingly, theanine was detected in tea from Potentilla fruticosa(1.16±0.81 mg/g). Furthermore, the content of polyphenols in teas from A. grossedentata, Acer tataricum subsp. ginnala are significantly higher than those from Camellia tea;teas from I. serra, Pistacia chinensis and A. tataricum subsp. ginnala have remarkable antioxidant activities similar to the activities from green tea(44.23 μg/m L). Purine alkaloids(caffeine, theobromine and theophylline) were not detected in non-Camellia teas. The investigation suggest some non-Camellia teas may be great functional natural products with potential for prevention of chronic diseases and aging,by providing with abundant polyphenols, antioxidants and specific FAAs. | Wu Bi Chunnian He Yunyun Ma Jie Shen Linghua Harris Zhang Yong Peng Peigen Xiao | 2016 | Acta Pharmaceutica Sinica B2016，6，2： | 11 |
| 7 | Complete chloroplast genome sequences of Schisandra chinensis:genome structure,comparative analysis,and phylogenetic relationship of basal angiosperms显示文摘Dear Editor,Schisandra chinensis(Turcz.)Baill.belongs to family Schisandraceae.Its fruit called'Wu Wei Zi'in Chinese is a well-known medicinal material,which is used to treat chronic cough and dyspnea,nocturnal emission,enuresis,etc.(National Pharmacopoeia Committee,2015).Except for S.chinensis,many species of Schisandraceae,such as S.sphenanthera,S.lancifolia and S.rubriflora,are used as the original plants of folk medicines.Although these species have similar traditional effects,modern | Haojie Guo Jiushi Liul Li Luo Xueping Wei Jin Zhang Yaodong Qi Bengang Zhang Haitao Liu Peigen Xiao | 2017 | Science China(Life Sciences)2017，60，11： | 9 |
| 8 | Preparation and arc erosion properties of Ag/Ti_2SnC composites under electric arc discharging显示文摘New Ag/Ti_2 SnC(Ag/TSC) composites with uniform microstructure were prepared by powder metallurgy. The superior wettability between Ag and Ti_2 SnC was confirmed with a contact angle of 14°. Arc erosion properties of Ag/10 wt%Ti_2 SnC(Ag/10 TSC) and Ag/20 wt%Ti_2 SnC(Ag/20 TSC) contacts were investigated under 400 V/100 A/AC-3 and compared with Ag/CdO contact.The Ag/10 TSC contact exhibited comparable arc erosion property to Ag/CdO contact. The fine arc erosion resistance was attributed to the good wettability between Ti_2 SnC and Ag,the good heat-conducting property of Ag/10 TSC, and the slight decomposition of Ti_2 SnC that absorbed part of electric arc energy. The excessive Ti_2 SnC significantly decreased the thermal conducting property of the Ag/20 TSC composite, resulting in the severe heat accumulation that decomposed Ti_2 SnC and deteriorated arc erosion property. The oxidation behavior of Ti_2 SnC under high electric arc temperature was also studied and then an arc erosion mechanism was proposed to get a comprehensive understanding on the arc erosion property of Ag/TSC composites. | Jianxiang DING Wubian TIAN Peigen ZHANG Min ZHANG Jian CHEN Yamei ZHANG Zhengming SUN | 2019 | Journal of Advanced Ceramics2019，8，1： | 9 |
| 9 | Effects of inoculating fungi on agilawood formation in Aquilaria sinensis显示文摘Agilawood is a costly heartwood medicine obtained from Aquilaria sinensis with active ingredients mainly composed of volatile and semi-volatile substances. However, the formation time of agilawood is quite long and little is known about its formation mechanism. Two highly active fungi obtained from natural agilawood were inoculated on A. sinensis trees to understand their interaction processes and elucidate the transformation rules of induced chemical compositions within different test periods. The results demonstrated that the fungi could successfully colonize living tissues and cells and activate the host defense system, resulting in agilawood accumulation. With increasing time, the main components of A. sinensis converted into constituents or analogs of agilawood and the host exhibited 'self-injury' to prevent fungal intrusion and protect other tissues. The data presented here could provide scientific basis for producing agilawood with the two new fungi in a safe, feasible, and sustainable manner without destroying rare Aquilaria plants. | CUI JinLong GUO ShunXing FU ShaoBin XIAO PeiGen WANG MengLiang | 2013 | Chinese Science Bulletin2013，58，26： | 8 |
| 10 | Slip casting and pressureless sintering of Ti3AlC2显示文摘Slip casting and subsequent pressureless sintering(PLS)allow the preparation of complex-shaped and large-sized Ti3AlC2 components for many potential applications.The behaviors of the suspensions,green compacts,and sintered samples of Ti3AlC2 were studied in this paper.The optimized condition of 1 wt%of arabic gum as dispersant at pH=10 results in a Ti3AlC2 suspension for slip casting Ti3AlC2 green compacts without macro defects or cracks.The sintering temperature and Al4C3 embedding powder are found to dominate the properties of the sintered Ti3AlC2 samples.The Ti3AlC2 sample sintered at 1450℃for 1.5 h with Al4C3 embedding powder reaches the best properties,namely 95.3%relative density,hardness of 4.18 GPa,thermal conductivity of 29.11W·m-1·K-1,and electrical resistivity of 0.39μΩ·m.The findings in this work may pave the way for the application of MAX phases with large size and complex shape. | Yimin GONG Wubian TIAN Peigen ZHANG Jian CHEN Yamei ZHANG Zhengming SUN | 2019 | Journal of Advanced Ceramics2019，8，3： | 6 |
| 11 | Anemone medicinal plants:ethnopharmacology,phytochemistry and biology显示文摘The Ranunculaceae genus Anemone(order Ranunculales),comprising more than 150 species,mostly herbs,has long been used in folk medicine and worldwide ethnomedicine.Various medicinal compounds have been found in Anemone plants,especially triterpenoid saponins,some of which have shown anti-cancer activities.Some Anemone compounds and extracts display immunomodulatory,antiinflammatory,antioxidant,and antimicrobial activities.More than 50 species have ethnopharmacological uses,which provide clues for modern drug discovery.Anemone compounds exert anticancer and other bioactivities via multiple pathways.However,a comprehensive review of the Anemone medicinal resources is lacking.We here summarize the ethnomedical knowledge and recent progress on the chemical and pharmacological diversity of Anemone medicinal plants,as well as the emerging molecular mechanisms and functions of these medicinal compounds.The phylogenetic relationships of Anemone species were reconstructed based on nuclear ITS and chloroplast markers.The molecular phylogeny is largely congruent with the morphology-based classification.Commonly used medicinal herbs are distributed in each subgenus and section,and chemical and biological studies of more unexplored taxa are warranted.Gene expression profiling and relevant 'omics' platforms could reveal differential effects of phytometabolites.Genomics,transcriptomics,proteomics,and metabolomics should be highlighted in deciphering novel therapeutic mechanisms and utilities of Anemone phytometabolites. | Da-Cheng Hao Xiaojie Gu Peigen Xiao | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 6 |
| 12 | Research progress in the phytochemistry and biology of Ilex pharmaceutical resources显示文摘Ilex is a botanical source for various health-promoting and pharmaceutically active compounds that have been used in traditional Chinese medicine and food for thousands of years.Increasing interest in Ilex pharmaceutical and food resources has led to additional discoveries of terpenoids,saponins,polyphenols(especially flavonoids),glycosides,and many other compounds in various Ilex species,and to investigation of their chemotaxonomy,molecular phylogeny and pharmacol-ogy.In continuation of our studies on Ilex pharmacology and phylogeny,we review the phytochemistry,chemotaxonomy,molecular biology and phylogeny of Ilex species and their relevance to health-promotion and therapeutic efficacy.The similarity and dissimilarity between Ilex paraguariensis,the source plant of mate tea,and the source plants of large-leaved K udingcha(e.g.,Ilex kudingcha and Ilex latifolia)are discussed.It is essential to utilize emerging technologies in non-Camellia tea studies to promote the sustainable utilization of Ilex resources and the identification and development of novel compounds with potential health and clinical utility.Systems biology and '-omics'technologies will play an increasingly important role in pharmaceutical and food research on the bioactive compounds of Ilex species. | Dacheng Hao Xiaojie Gua Peigen Xiao Zhanguo Liang Lijia Xu Yong Peng | 2013 | Acta Pharmaceutica Sinica B2013，3，1： | 6 |
| 13 | Spontaneous Growth of Metal Whiskers on Surfaces of Solids:A Review显示文摘Spontaneous metal whisker growth phenomenon has been studied for^70 years,but still resists interpretations,which has haunted the electronics-rich systems from the birth of the industry since whiskers may lead to short circuits and hence other disasters.In addition to reliability problems,threat of Pb whiskers to human health is also significant due to the toxicity of the element and its geometry as well as its nanometer size.This issue becomes more attention drawing and urgent due to the restrictions on Pb use in EU,Japan etc.,which phases out the Pb-addition practice to mitigate Sn whiskers.This paper reviews the origin of the whiskering phenomenon and whisker-induced problems,ranging from early in the World War Ⅱ to the present;details the development of this issue in the electronics-rich systems including the phenomenon,problems and remedies;pictures the long history of the developments of the growth mechanisms and models which are full of hardship and contradictions.New aspects on the spontaneous whisker growth in some different substrates,such as in brasses and MAX phase materials are reviewed in more details.The latter was found to be a promising system to understand the whisker growth phenomenon,with new growth models proposed that may shed new light to the intricate battle field of the metal whisker research in general. | Peigen Zhang Yamei Zhang Zhengming Sun | 2015 | Journal of Materials Science & Technology2015，31，7： | 5 |
| 14 | From structural ceramics to 2D materials with multi-applications:A review on the development from MAX phases to MXenes显示文摘MAX phases(Ti_(3)SiC_(2),Ti_(3)AIC_(2),V_(2)AlC,TiqAlN_(3),etc.)are layered ternary carbides/nitrides,which are generally processed and researched as structure ceramics.Selectively removing A layer from MAX phases,MXenes(Ti_(3)C_(2),V_(2)C,Mo_(2)C,etc.)with two-dimensional(2D)structure can be prepared.The MXenes are electrically conductive and hydrophilic,which are promising as functional materials in many areas.This article reviews the milestones and the latest progress in the research of MAX phases and MXenes,from the perspective of ceramic science.Especially,this article focuses on the conversion from MAX phases to MXenes.First,we summarize the microstructure,preparation,properties,and applications of MAX phases.Among the various properties,the crack healing properties of MAX phase are highlighted.Thereafter,the critical issues on MXene research,including the preparation process,microstructure,MXene composites,and application of MXenes,are reviewed.Among the various applications,this review focuses on two selected applications:energy storage and electromagnetic interference shielding.Moreover,new research directions and future trends on MAX phases and MXenes are also discussed. | Aiguo ZHOU Yi LIU Shibo LI Xiaohui WANG Guobing YING Qixun XIA Peigen ZHANG | 2021 | Journal of Advanced Ceramics2021，10，6： | 4 |
| 15 | Commercialized non-Camellia tea:traditional function and molecular identification显示文摘Non-Camellia tea is a part of the colorful Chinese tea culture,and is also widely used as beverage and medicine in folk for disease prevention and treatment.In this study,37 samples were collected,including 33 kinds of non-Camellia teas and 4 kinds of teas(Camellia).Traditional functions of non-Camellia teas were investigated.Furthermore,non-Camellia teas of original plants were characterized and identified by molecular methods.Four candidate regions(rbcL,matK,ITS2,psbA-trnH)were amplified by polymerase chain reaction.In addition,DNA barcodes were used for the first time to discriminate the commercial non-Camellia tea and their adulterants,and to evaluate their safety.This study showed that BLASTN and the relevant phylogenetic tree are efficient tools for identification of the commercial non-Camellia tea and their adulterants.However,some sequences from original plants have not been found and there is a limitation of sequence number of original plants in GenBank.Submitting more original plant sequences to the GenBank will be helpful for evaluating the safety of non-Camellia teas. | Ping Long Zhanhu Cui Yingli Wang Chunhong Zhang Na Zhang Minhui Li Peigen Xiao | 2014 | Acta Pharmaceutica Sinica B2014，4，3： | 3 |
| 16 | ACCURACY ANALYSIS FOR PLANAR LINKAGE WITH MULTIPLE CLEAR-ANCES AT TURNING PAIRS显示文摘Clearance at turning pair has a strong impact on the kinetic accuracy of linkage,but there is short of a generic model to analyze it so far.Clearance error,input error,and manufacturing tolerance of links are taken into consideration as the random variables synthetically.The kinematics and dynamics accuracy analysis models for planar linkages with multiple clearances at joints are built up as well.At last a typical planar linkage is selected for numerical illustration.These models stated in matrix resolve the relativity of output parameter errors of mechanism and therefore are of vital significance for the reliability analysis and synthesis of mechanism with clearances. | ZHANG Guojun CHENG Qiang SHAO Xinyu LI Peigen | 2008 | Chinese Journal of Mechanical Engineering2008，21，2： | 3 |
| 17 | An ethnopharmacological investigation of medicinal Salvia plants (Lamiaceae) in China显示文摘In China,over 40 species of the genus Salvia have been used as medicinal plants for various diseases,some for thousands of years.Recently,research has focused on the biological activities of Salvia medicinal plants used in traditional chinese medicine(TCM).However,to date a scientific survey of the genus Salvia in China has not been carried out.In this paper,we report the results of 10 field surveys of Salvia medicinal plants collected in 17 provinces including detailed information on their local names,growing environment,distribution and therapeutic effects.We also summarize the results of research on the materia medica,phytochemistry and pharmacology of some of the important Salvia medicinal plants.Our study reveals that 35 Salvia plants have been used in TCM in different regions of China,including 20 species used as Danshen to treat heart diseases,and 15 species used to treat a range of other conditions including gynecological diseases,muscular or skeletal problems,hepatitis,urological diseases,and mouth and eye conditions.It is clear that some species of Salvia L.possess significant pharmacological activity in the context of ethnopharmacological knowledge,especially in the treatment of heart disease.Further studies of the phytochemistry and pharmacology of Salvia species will no doubt improve their medical utilization and contribute to the development of new natural drugs. | Minhui Li Qianquan Li Chunhong Zhang Na Zhang Zhanhu Cui Luqi Huang Peigen Xiao | 2013 | Acta Pharmaceutica Sinica B2013，3，4： | 2 |
| 18 | Experimental investigations of granular shape effects on the generation of electrostatic charge显示文摘In solid processing systems,electrostatic problems are commonly observed for granules of various shapes.However,a complete understanding of the basic dependence of electrostatic charge generation on particle shape has yet to be established.This observation motivated the present study on examining the effect of granular shape on electrostatics.In this study,polyvinyl chloride(PVC) granules(diameter 1.1-4.1 mm,in the shape of a triangle or trapezium) were first discharged to remove any residual charges and subsequently their electrostatic charging characteristics were studied by allowing a granule to slide along a pipe wall.Several factors such as granular front-facing angle,length-ratio,sliding area,sliding orientation,sliding times,and relative humidity were considered when studying their effects on the electrostatic charging of granules.It was found that triangular granules with smaller front-facing angles tended to generate more electrostatic charge.The amount of electrostatic charge increased with granular lengthratio and sliding area but decreased with humidity.In addition,granular sliding in the orientation of the front-facing angle(for triangular granules) or the short side(for trapezoidal granules) generated more electrostatic charge than that in the orientation of the long side.For both granule shapes,the electrostatic charge increased with granular sliding times and reached a saturated state after around 8-9 sliding movements.The saturated electrostatic charge increased with either granular length ratio or sliding area. | Jun Yao Jiejie Wu Yanlin Zhao Eldin Wee Chuan Lim Peigen Cao Fang Zhou Chi-Hwa Wang Ning Li | 2014 | Particuology2014，12，4： | 2 |
| 19 | Research progress of Chinese herbal medicine compounds and their bioactivities:Fruitful 2020显示文摘Traditional Chinese medicines(TCMs)have continued to be a treasure trove.The study of chemodiversity and versatility of bioactivities has always been an important content of pharmacophylogeny.There is amazing progress in the discovery and research of natural components with novel structures and significant bioactivities in 2020.In this paper we review 271 valuable natural products,including terpenoids,steroids,flavonoids,phenylpropanoids,phenolics,nitrogen containing compounds and essential oil,etc.,isolated and identified from TCMs published in journals of Chinese Traditional and Herbal Drugs(Zhong Cao Yao)and Chinese Herbal Medicines(CHMs),and focus on their structures,source organisms,and relevant bioactivities,paying special attention to structural characteristics of novel compounds and newly revealed pharmacological properties of known compounds.It is worth noting that natural products with antitumor activity still constitute the primary object of research.Among the reported compounds,two new triterpenoids,i.e.,ursolic acid 3-O-β-cis-caffeate and mollugoside E,display remarkable cytotoxicity against PC-9 and HL-60 cell lines,respectively.Three known phenolic compounds,i.e.,pyoluteorin,4-hydroxy-3-methoxy cinnamaldehyde and 3,7-dimethoxy-5-hydroxy-1,4-phenanthrenequinone,exhibit significant cytotoxicity against multiple cell lines.Numerous studies on the free radical scavenging activity of reported compounds are currently underway.In vitro,three known phenolic compounds,i.e.,3,4-Odicaffeoylquinic acid methyl ester,3,4,5-O-tricaffeoylquinic acid methyl ester and arbutin,had more considerable antioxidant activities than vitamin C.The anti-inflammatory,anti-diabetic,hypolipidemic,neuroprotective and antimicrobial activities of isolated compounds are also encouraging.The structural characteristics and bioactivities of TCM compounds highlighted here reflect the enormous progress of CHM research in 2020 and will play a positive role in the future drug discovery and development.According to pharmacophylogeny,the phylogenetic distribution of compounds with different natures and flavors can be explored,with view to better mining TCM resources. | Xiaojie Gu Dacheng Hao Peigen Xiao | 2022 | Chinese Herbal Medicines2022，14，2： | 2 |
| 20 | An effective hybrid particle swarm optimization algorithm for multi-objective flexible job-shop scheduling problem显示文摘 | Guohui Zhang Xinyu Shao Peigen Li Liang Gao | 2008 | Computers & Industrial Engineering2008，，4： | 2 |
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