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| 1 | Connexin 43 hemichannels protect bone loss during estrogen deficiency显示文摘Estrogen deficiency in postmenopausal women is a major cause of bone loss,resulting in osteopenia,osteoporosis,and a high risk for bone fracture.Connexin 43 (Cx43) hemichannels (HCs) in osteocytes play an important role in osteocyte viability,bone formation,and remodeling.We showed here that estrogen deficiency reduced Cx43 expression and HC function.To determine if functional HCs protect osteocytes and bone loss during estrogen deficiency,we adopted an ovariectomy model in wild-type (WT) and two transgenic Cx43 mice:R76W (dominant-negative mutant inhibiting only gap junction channels) and Cx43 Δ130–136 (dominant-negative mutant compromising both gap junction channels and HCs).The bone mineral density (BMD),bone structure,and histomorphometric changes of cortical and trabecular bones after ovariectomy were investigated.Our results showed that the Δ130–136 transgenic cohort had greatly decreased vertebral trabecular bone mass compared to WT and R76W mice,associated with a significant increase in the number of apoptotic osteocyte and empty lacunae.Moreover,osteoclast surfaces in trabecular and cortical bones were increased after ovariectomy in the R76W and WT mice,respectively,but not in Δ130–136 mice.These data demonstrate that impairment of Cx43 HCs in osteocytes accelerates vertebral trabecular bone loss and increase in osteocyte apoptosis,and further suggest that Cx43 HCs in osteocytes protect trabecular bone against catabolic effects due to estrogen deficiency. | Liang Ma Rui Hua Yi Tian Hongyun Cheng Roberto Jose Fajardo Joseph J. Pearson Teja Guda Daniel Brian Shropshire Sumin Gu Jean X. Jiang | 2019 | Bone Research2019，7，2： | 11 |
| 2 | A community-based, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP IlI goals for LDL cholesterol in hypercholesterolemic patients: the ezetimibe add-on to statin for effectiveness (EASE) trial 显示文摘 | Pearson TA Denke MA McBride PE | 2005 | Mayo Clin Proc2005，80，5： | 1 |
| 3 | Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sin-like protein 显示文摘 | Schumacher MA Pearson RF Moller T | 2002 | EMBO J2002，21，13： | 1 |
| 4 | A community-based, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP Ⅲ goals for LDL cholesterol in hypercholesterolemic patients: the ezetimibe add-on to statin for effectiveness (EASE) trial显示文摘 | Pearson TA Denke MA McBride PE | 2005 | Mayo Clin Proc2005，80，5： | 1 |
| 5 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 6 | A community-based, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP Ⅲ goals for LDL cholesterol in hypercholesterolemic patients: the ezetimibe add-on to statin for effectiveness (EASE) trial显示文摘 | Pearson TA Denke MA McBride PE | 2005 | Mayo Clin Proc2005，80，5： | 1 |
| 7 | Investigation of a Campylobacter jejuni outbreak by serotyping and chromosomal restriction endonuclease analysis 显示文摘 | Bradbury WC Pearson AD Marko MA | 1984 | J Clin Microbiol1984，19，3： | 1 |
| 8 | Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain显示文摘 | Pearson MA Reczek D Bretscher A | 2000 | Cell2000，101，3： | 1 |
| 9 | A community-based,randomized trial of ezetimibe added to statin therapy to attain NCEP ATP Ⅲ goals for LDL cholesterol in hypercholeserolemic patients:the ezetimibe add-on to statin for effectiveness(EASE)trial显示文摘 | Pearson TA Denke MA McBride PE | 2005 | Mayo Clin Proc2005，80，5： | 1 |
| 10 | The safely profile of long-term, high-dose intraoeular corticosteroid delivery 显示文摘 | Holekamp NM Thomas MA Pearson A | 2005 | Am J Ophthahnol2005，139，： | 1 |
| 11 | A community based, randomized trial of ezetimibe added tostatin therapy to attain NCEP ATP Ⅲ goals for LDL cholesterol in hypercholes terolemic patients: the ezetimibe add-on tO statin for effectiveness (EASE) trial 显示文摘 | Pearson TA Denke MA McBride PE | 2005 | Mayo Clin Proc2005，80，： | 1 |
| 12 | In vivo antitumor activity of NVP-AEW541-a novel, potent, and se lective inhibitor of the IGF-IR kinase显示文摘 | Garcia-Echeverria C Pearson MA Marti A | 2004 | Cancer Cell2004，5，3： | 1 |
| 13 | Importancee of findings on the initial evaluation of cancer in individual with symptomatic idiopathic deep venous thrombosis显示文摘 | Pearson SD Creager MA | 1996 | Ann Intern Med1996，12，5： | 1 |
| 14 | Transesophaged e-chocardiograhic characterization of pulmonary vein flow notdue to attraction of mitral regurgitation显示文摘 | Pasierski TJ Alton MA Pearson AC | 1991 | Am J Cardiol1991，68，4： | 1 |
| 15 | Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain 显示文摘 | Pearson MA Reczek D Bretscher A | 2000 | Cell2000，101，3： | 1 |
| 16 | Importance of findings on the initial evolution of cancer in individual with symptomatic idiopathic deep venous thrombosis显示文摘 | Comugz J Pearson SD Creager MA | 1996 | Ann Intern Med1996，125，： | 1 |
| 17 | Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain显示文摘 | Curtis MA Penney EB Pearson AG | 2003 | Proc Natl Acad Sci USA2003，100，15： | 1 |
| 18 | The safety profile of long-term ,high-dose intraocular corticosteroid delivery 显示文摘 | Holekamp NM Thomas MA Pearson A | 2005 | Am J Ophthalmol2005，139，3： | 1 |
| 19 | Respite for caregivers:an evaluation study显示文摘 | Theis SL Moss JH Pearson MA | 1994 | J Community Health Nurs1994，11，1： | 1 |
| 20 | Exploring the roles of the metal ions in Escherichia coli copper amine oxidase显示文摘 | Smith MA Pirrat P Pearson AR | 2010 | Biochemistry2010，49，6： | 1 |
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