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| 1 | Is the sentinel lymph node biopsy more sensitive for the identification of positive lymph nodes in breast cancer than the axillary lymph node dissection?显示文摘 | Ann Smeets Emi Yoshihara Annouschka Laenen Anneleen Reynders Julie Soens Hans Wildiers Robert Paridaens Chantal Van Ongeval Giuseppe Floris Patrick Neven Marie-Rose Christiaens | 2013 | SpringerPlus2013，，： | 1 |
| 2 | Feasibility study of computed tomography colonography using limited bowel preparation at normal and low-dose levels study显示文摘 | Jasper Florie Rogier E. Gelder Michiel P. Schutter Adrienne Randen Henk W. Venema Steven Jager Victor P. M. Hulst Anna Prent Shandra Bipat Patrick M. M. Bossuyt Lubbertus C. Baak Jaap Stoker | 2007 | European Radiology2007，，12： | 1 |
| 3 | Feasibility study of computed tomography colonography using limited bowel preparation at normal and low-dose levels study显示文摘 | Jasper Florie Rogier E. Gelder Michiel P. Schutter Adrienne Randen Henk W. Venema Steven Jager Victor P. M. Hulst Anna Prent Shandra Bipat Patrick M. M. Bossuyt Lubbertus C. Baak Jaap Stoker | 2007 | European Radiology2007，，12： | 1 |
| 4 | Silver doped titanium dioxide nanomaterials for enhanced visible light photocatalysis显示文摘 | Michael K Seery Reenamole George Patrick Floris | 2007 | J Photochem Photobiol A2007，189，23： | 1 |
| 5 | Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS显示文摘Ensuring the removal of host cell proteins(HCPs) during downstream processing of recombinant proteins such as monoclonal antibodies(m Abs) remains a challenge.Since residual HCPs might affect product stability or safety,constant monitoring is required to demonstrate their removal to be below the regulatory accepted level of 100 ng/mg.The current standard analytical approach for this procedure is based on ELISA;however,this approach only measures the overall HCP content.Therefore,the use of orthogonal methods,such as liquid chromatography-mass spectrometry(LC-MS),has been established,as it facilitates the quantitation of total HCPs as well as the identification and quantitation of the individual HCPs present.In the present study,a workflow for HCP detection and quantitation using an automated magnetic bead-based sample preparation,in combination with a data-independent acquisition(DIA) LC-MS analysis,was established.Employing the same instrumental setup commonly used for peptide mapping analysis of m Abs allows for its quick and easy implementation into pre-existing workflows,avoiding the need for dedicated instrumentation or personnel.Thereby,quantitation of HCPs over a broad dynamic range was enabled to allow monitoring of problematic HCPs or to track changes upon altered bioprocessing conditions. | Lisa Strasser Giorgio Oliviero Craig Jakes Izabela Zaborowska Patrick Floris Meire Ribeiro da Silva Florian Füssl Sara Carillo Jonathan Bones | 2021 | Journal of Pharmaceutical Analysis2021，11，6： | 0 |
| 6 | “坐”看云卷云舒显示文摘我喜欢在周末的午后,煮一壶咖啡,捧着iPad,慵懒在沙发里,可以暂时远离喧嚣的世界,沉浸在静谧的时光中。屋内弥漫着咖啡的香气,窗外阳光和煦,闲逸而悠然。如今这个追求速度的时代,生活总是很忙碌,忙碌中我们来不及感受,漠视了关爱。那种坐看云卷云舒,静听花开花落的惬意与闲适似乎在很多时候都显得可望而不可即。 | Cate & Nelson Eero Koivisto Floris Wubben Hyeonil Jeong Juan Cappa Lufer+Keichel position-collective Patrick Norguet Ryosuke Fukusada studio Fattorini+Rizzini+Partners Simon Legald Tommaso Caldera Tjalle & Jasper 伏平 范嘉苑 | 2015 | 现代装饰(家居)2015，0，5： | 0 |
| 7 | Antitubercular activity of the semi-polar extractives of Uvaria rufa显示文摘Objective:To investigate the inhibitory activity of the chloroform extract,petroleum ether and chloroform sub-extracts,lead-acetate treated chloroform extract,fractions and secondary metabolites of Uvaria rufa(U.rufa) against Mycobacterium tuberculosis(M.tuberculosis) H37Rv. Methods:The antituberculosis susceptibility assay was earried out using the colorimetric Microplate Alamar blue assay(MABA).In addition,the cytotoxicity of the most active fraction was evaluated using the VERO cell toxicity assay.Results:The in vitro inhibitory activity against M.tuberculosis H37Rv increased as purification progressed to fractionation(MIC up to 23μg/mL). The chloroform extract and its sub-extracts showed moderate toxicity while the most active fraction from chloroform sub-extract exhibited no cytotoxicity against VERO cells.Meanwhile, the lead acetate-treated crude chloroform extract and its fractions showed complete inhibitions (100%) with MIC values up to 8μg/mL.Phylochemical screening of the most active fraction showed,in general,the presence of terpenoids,steroids and phenolic compounds.Evaluation of the antimycobacterial activity of known secondary metabolites isolated showed no promising inhibitory activity against the test organism.Conclusions:The present results demonstrate the potential of U.rufa as a phytomedicinal source of compounds that may exhibit promising antituberculosis activity.In addition,elimination of polar pigments revealed enhanced inhibition against M.tuberculosis H37Rv.While several compounds known for this plant did not show antimycobacterial activity,the obtained results are considered sufficient reason for further study to isolate the metabolites from U.rufa responsible for the antitubercular activity. | Allan Patrick G Macabeo Florie A Tudla Karsten Krohn Scott G Franzblau | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，10： | 0 |
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