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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | A new class of folding oligomers: crescent oligoamides显示文摘 | Zhu J Parra R D Zeng H | 2000 | J Am Chem Soc2000，122，： | 1 |
| 3 | A fuzzy goal pro- gramming approach to portfolio selection显示文摘 | Parra M A Terol A B Uria M V R | 2001 | European Journal of Operational Research2001，133，： | 1 |
| 4 | Methylene blue attenuates ischemia-reperfusion injury in lung transplantation显示文摘 | Abreu Mda M Pazetti R Almeida FM Correia AT Parra ER Silva LP | 2014 | J Surg Res2014，192，2： | 1 |
| 5 | Estrogen receptor βprotein in human breast cancer; correlation with clinical tumor parameters 显示文摘 | Fuqua SA Schiff R Parra I | 2003 | Cancer Res2003，63，： | 1 |
| 6 | Characterization of palladium supported on sulfated zirconia catalysts by DRIFTS,XAS and n-butane isomerization reaction in the presence of hydrogen 显示文摘 | Lotero E Parra R D | 1995 | Appl Catal A1995，，130： | 1 |
| 7 | Analysis of epidermal growth factor receptor expression as a predictive factor for response to gefitinib (Iressa, ZD1839) in non-small-cell lung cancer显示文摘 | Parra HS Cavina R Latteri F | 2004 | Br J Cancer2004，91，2： | 1 |
| 8 | PCR amplifica- tion of the Irish potato famine pathogen from historic specimens 显示文摘 | RISTAINO J B GROVES C T PARRA G R | 2001 | Nature2001，411，6838： | 1 |
| 9 | Rivaroxaban versus warfarin in non valvular atrial fibrillation显示文摘 | Rosenstein R Parra D | 2011 | N Engl J Med2011，365，24： | 1 |
| 10 | Exposure to Volatile Organic Compounds(VOC) in Public Buses of Pamplona,Northern Span显示文摘 | Parra M A Elustondo D Bermejo R | 2008 | Science of The TotalEnvironment2008，，404： | 1 |
| 11 | An experimental study on pitch compensation in pedestrian-protection systems for collision avoidance and mitigation 显示文摘 | Llorca D R Sotelo M A Parra I | 2009 | IEEE Transactions on Intelligent Transportation Systems2009，10，3： | 1 |
| 12 | Very high resolution interpolated climate surfaces for global land areas显示文摘 | Hijmans R J Cameron S E Parra J L | 2005 | International Journal of Climatology2005，25，15： | 1 |
| 13 | Laparoscopic cysteetomy: initial report on a new treatment for the retained bladder 显示文摘 | Parra R O Andrus C H Jones J P | 1992 | J Urol1992，148，4： | 1 |
| 14 | Recovery of iron from copper flash smelting slags 显示文摘 | BUSOLIC D PARADA F PARRA R SANCHEZ M PALACIOS J HINO M | 2011 | Trans Inst Min Metall C2011，120，： | 1 |
| 15 | Very high resolution interpolated climate surfaces for global land areas显示文摘 | Hijmans R J Cameron S E Parra J L | 2005 | International Journal of Climatology2005，25，15： | 1 |
| 16 | PCR amplification of the Irish potato famine pathogen from historic specimens 显示文摘 | Ristanio J B Groves C T Parra G R | 2001 | Nature2001，411，： | 1 |
| 17 | Energy-preserving effects of IGF-l antagonize starvation-induced cardiac autophagy显示文摘 | Troncoso R Vicencio]M Parra V | 2012 | Cardiovasc Res2012，93，2： | 1 |
| 18 | Very High Reso lution Interpolated Climate Surfaces for Global Land Areas显示文摘 | Hijmans R J Cameron S E Parra J L | 2005 | International Journal of Climatology2005，25，： | 1 |
| 19 | Water and temperature relations of growth and ochratoxin A production by Aspergillus carbonarius strains from grapes in Europe and Israe 显示文摘 | Mitchell D Parra R Aldred D | 2004 | J Appl Microbiol2004，97，2： | 1 |
| 20 | A polaronic stacking faultdefect model for CaCu3Ti40i2 material: an approach for the origin of thehuge dielectric constant and semiconducting coexistent features 显示文摘 | BUENO P R TARARAN R PARRA R | 2009 | JPhys D Appl Phys2009，42，05： | 1 |
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