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| 1 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know显示文摘Granulocyte 巨噬细胞刺激殖民地的因素(GM-CSF ) 是一个重要造血的生长因素和有免疫力的调节的人。GM-CSF 也在各种各样的传播白血球的功能的活动有深刻效果。它被许多房间类型在收到有免疫力的刺激之上包括 T 房间,巨噬细胞, endothelial 房间和成纤维细胞生产。尽管 GM-CSF 局部地被生产,它能以一种 paracrine 方式行动到在主人防卫提高他们的功能的成员传播 neutrophils,单核白血球和淋巴细胞。最近的集中的调查为它增加树枝状的房间(DC ) 成熟和功能以及巨噬细胞活动的能力作为一个有免疫力的助手在 GM-CSF 的应用程序上被集中。在经历化疗的癌症病人对待嗜中性白血球减少症临床上被使用,在在治疗期间的爱滋病病人,并且在在骨髓移植以后的病人。有趣地, GM-CSF-deficient 老鼠的造血的系统看起来正常;最重要的变化在一些特定的 T 房间回答。尽管 GM-CSF 的分子的克隆用 T 房间的 cDNA 图书馆被执行, T 房间在激活以后生产 GM-CSF,是众所周知的,在 T 房间功能上有在由 T 房间和它的效果的生产的这 cytokine 的系统的调查的缺乏。在这篇文章,我们将在 T 房间主要集中于 GM-CSF 的免疫生物学。 | Yufang Shi Catherine H Liu Arthur I Roberts Jyoti Das Guangwu Xu Guangwen Ren Yingyu Zhang Liying Zhang Zeng Rong Yuan Hung Sheng William Tan Gobardhan Das Satish Devadas | 2006 | Cell Research2006，16，2： | 22 |
| 2 | An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants显示文摘Abscisic 酸(骆驼毛的织物) 是最重要的荷尔蒙让植物抵抗干旱和另外的不能生活的压力。骆驼毛的织物直接绑在骆驼毛的织物受体的 PYR/PYL 家庭,导致类型 2C 磷酸酶(PP2C ) 和下游的骆驼毛的织物发信号的激活的抑制。骆驼毛的织物由小分子发信号的干预能帮助植物克服象干旱,寒冷和土壤咸度那样的不能生活的压力,这被想象。然而,由植物酶的化学不稳定性和快速的分解代谢限制骆驼毛的织物本身的实际申请。这里,我们报导一件小分子骆驼毛的织物的鉴定模仿(AM1 ) 那充当骆驼毛的织物受体的家庭的多重成员的有势力使活跃之物。在 Arabidopsis, AM1 激活高度类似于由骆驼毛的织物导致了那的一个基因网络。有 AM1 的处理禁止种子萌芽,阻止叶水损失,并且支持干旱抵抗。我们与 PYL2 骆驼毛的织物受体和 HAB1 PP2C 在建筑群解决了 AM1 的水晶结构,它表明 AM1 调停交往的 gate-latch-lock 网络,在骆驼毛的织物界限 receptor/PP2C 建筑群被保存的一个结构的特征。一起,这些结果证明一件单个小分子骆驼毛的织物模仿能激活多重骆驼毛的织物受体并且保护植物免受水损失和干旱应力的伤害。而且, AM1 复杂水晶结构为设计 ABA-mimicking 小分子的下一代提供一个结构的基础。 | Minjie Cao Xue Liu Yan Zhang Xiaoqian Xue X EdwardZhou Karsten Melcher Pan Gao Fuxing Wang Liang Zeng Yang Zhao Pan Deng Dafang Zhong Jian-Kang Zhu H Eric Xu Yong Xu | 2013 | Cell Research2013，23，8： | 17 |
| 3 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 4 | Research on optimal immunization strategies for hepatitis B in different endemic areas in China显示文摘INTRODUCTION At present hepatitis B vaccine immunization is an unique effective measure for controlling hepatitis B.It is important o determine optimal immunization | Li H Wang L Wang SS Gong J Zeng XJ Li RC Nong Y Huang YK Chen XR Huang ZN | 2000 | World Journal of Gastroenterology2000，6，3： | 9 |
| 5 | Moving Force Identification - Time Domain Method显示文摘 | Law S S Chan T H T Zeng Q H | 1997 | Journal of Sound and Vibration1997，201，1： | 4 |
| 6 | Microbial production of 1,3-propanediol显示文摘 | Biebl H Menzel K Zeng A P | | 0，，： | 3 |
| 7 | 2003—2015年中国恶性肿瘤生存率变化:基于17个以人群为基础的肿瘤登记处数据的汇总分析显示文摘中国2003—2015年恶性肿瘤生存率远低于发达国家,且存在很大的地域差异性,以人群为基础的肿瘤生存率数据对了解我国肿瘤防治效果至关重要,因此本研究着重分析2003-2015年间中国恶性肿瘤患者的生存情况及变化趋势。本研究从中国国家癌症中心肿瘤登记中心抽取17个肿瘤登记点的肿瘤登记资料,包括2003—2013年间所有诊断为原发性浸润性恶性肿瘤患者(年龄为0~99岁),及其截至2015年12月31日的生存状态随访数据,分析了2003—2015年间所有恶性肿瘤及26个不同癌种的5年相对生存率,并按不同性别、年龄和地域分布进行描述和分析。 | Zeng H Chen W Zheng R 谢双华(编译) | 2019 | 中华预防医学杂志2019，53，12： | 3 |
| 8 | Microbial production of 1,3-propanediol显示文摘 | Biebl H Menzel K Zeng A P | 1999 | Appl Microbiol Biotechnol1999，52，： | 2 |
| 9 | On Timing Offset Estimation for OFDM Systems显示文摘 | Minn H Zeng M Bhargava V K | | 0，，： | 2 |
| 10 | A Staggered-grid Finite-difference Method with Perfectly Matched Layers for Poroelastic Wave Equations显示文摘 | Zeng Y Q Liu Q H | 2001 | J Acoust Soc Am2001，109，6： | 2 |
| 11 | Genistein Down-Regulates miR-223 Expression in Pancreatic Cancer Cells显示文摘 | Jia Ma Long Cheng Hao Liu Jing Zhang Ying Shi Fanpeng Zeng Lucio Miele Fazlul H Sarkar Jun Xia Zhiwei Wang | 2013 | Current Drug Targets2013，，10： | 2 |
| 12 | Pathway analysis of glycerol fermentation by Klebsiella pneumoniae regulation of reducing equivalent balance and product formation显示文摘 | Zeng AP Biebl H Schlieker H | 1993 | Enzyme Microbiol Technol1993，15，： | 2 |
| 13 | Alkane-assisted adsorption and assembly of phthalocyanines and porphyrins显示文摘 | Qiu X H Wang C Zeng Q D | | 0，，： | 2 |
| 14 | Moving Force Identification - A Frequency and Time Domains Approach显示文摘 | LawSS Chan T H T Zeng Q H | 1999 | Journal of Dynamic Systems Measurement and Control ASME1999，121，3： | 2 |
| 15 | Effect of a Patient Education Intervention on Asthma Control and Patient-Doctor Relationship显示文摘 | Yu-Qin Zeng David H Au Shan Cai Evan Carey Fen Jiang Yan Chen Zhi-Jun Liu Ping Chen | 2018 | Chinese Medical Journal2018，，9： | 2 |
| 16 | Bulk chemicals from biotechnology:the case of 1,3-propanediol production and the new trends显示文摘 | Zeng A P Biebl H | 2002 | Advances in Biochemical Engineering/Biotechnology2002，74，： | 2 |
| 17 | Seed coat microsculpturing changes during seed development in diploid and amphidipoid Brassic species显示文摘 | ZENG C L WANG J B LIU A H | 2004 | Annals of Botany2004，93，： | 1 |
| 18 | More active PtRu/C catalyst for methanol electrooxidation by reversal of mixing sequence in catalyst preparation 显示文摘 | ZENG J H LEE J Y | 2007 | Materials Chemistry and Physics2007，104，： | 1 |
| 19 | Improved effects of a double suicide gene system on prostate cancer cells by targeted regulation of prostate-specific membrane antigen promoter and enhancer 显示文摘 | Zhang P Zeng H Wei Q | 2008 | Int J Urol2008，15，5： | 1 |
| 20 | Voltammetric behavior and determination of rutin at a single-walled carbon nanotubes modified gold electrode 显示文摘 | ZENG B Z WEI S H XIAO F | 2006 | Sensors and Actuators B2006，115，： | 1 |
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