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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Influence of vegetable shortening and emulsifiers on the unfrozen water content and textural properties of frozen French bread dough显示文摘 | MATUDA T G PARRA D F LUGAO A B | 2005 | Lebensmittel Wissenschaft und Technologie2005，38，： | 1 |
| 3 | Recovery of iron from copper flash smelting slags 显示文摘 | BUSOLIC D PARADA F PARRA R SANCHEZ M PALACIOS J HINO M | 2011 | Trans Inst Min Metall C2011，120，： | 1 |
| 4 | Porcine Acute Phase Protein Concentrations in Different Diseases in Field Conditions显示文摘 | M D Parra P Fuentes F Tecles | 2006 | Journal of Veterinary Medicine2006，53，10： | 1 |
| 5 | Rheic Ocean ophiolitic remnants in southern Ibeda questioned by SHRIMP U-Pb zircon ages on the Beja-Acebuches amphibolites显示文摘 | Azor A Rubatto D Simancas J.F González Lodeiro F Martínez Poyatos D Martín Parra L.M Matas J | | 0，，： | 1 |
| 6 | Influence of Fibers on the Mechanical Properties of Cassava Starch Foams显示文摘 | CARR L G PARRA D F PONCE P | 2006 | Journal of Polymers and the Environment2006，14，2： | 1 |
| 7 | Tomographic study ofthe inflection points of the Pressure-volume curve in acute lung injury显示文摘 | Albaiceta GM Taboada F Parra D | 2004 | Am J Respir Crit Care Med2004，170，： | 1 |
| 8 | Influence of vegetable shortening and emulsifiers on the unfrozen water content and textural properties of frozen French bread dough显示文摘 | MATUDA T G PARRA D F LUGAO A B | 2005 | Lebensmittel Wissenschaft und Technologie2005，38，： | 1 |
| 9 | Robust visual odometry for vehicle localization in urban environments显示文摘 | Parra I Sotelo M A Llorca D F | 2010 | Robotica2010，28，3： | 1 |
| 10 | Destratification by mechanical mixers: Mixing efficiency and flow scaling显示文摘 | Hill D F Vergara A M Parra E J | 2008 | Journal of Hydraulic Engineering2008，134，12： | 1 |
| 11 | Robust visual odometry for vehicle localization in urban environments 显示文摘 | Parra I Sotelo M A Lorca D F | 2010 | Robotica2010，28，3： | 1 |
| 12 | Magnetic polymeric microspheres for protein adsorption显示文摘 | Felinto M C F C Parra D F Lugao A B | 2005 | J Nuclear Instruments and Methods in Physics Research2005，236，14： | 1 |
| 13 | Some synergistic effects of antioxidants in natural rubber显示文摘 | Parra D F Matos J D | 2002 | Journal of Thermal Analysis and Calorimetry2002，67，2： | 1 |
| 14 | Mechanical properties and water vapor transmission in some blends of cassava starch edible films显示文摘 | PARRA D F P TADINI C C PONCE P | 2004 | Carbohydrate Polymers2004，58，4： | 1 |
| 15 | Study of Gel Formation by Ionizing Radiation in Polypmpylene 显示文摘 | Oliani W L Parra D F Femaino D M | 2013 | Radi- ation Physics and Chemistry2013，84，3： | 1 |
| 16 | Mechanical properties and water vapor transmission in some blends of cassava starch edible films显示文摘 | PARRA D F TADINI C C PONCE P | 2004 | Carbohydrata Polymers2004，58，： | 1 |
| 17 | Mechanical Properties and Water Vapor Transmission in Some Blends of Cassava Starch Edible Films显示文摘 | PARRA D F TADINI C C PONCE P | 2004 | Carbohydrate Polymers2004，58，： | 1 |
| 18 | Mechanical Properties and Water Vapor Transmission in Some Blends of Cassava Starch Edible Films显示文摘 | PARRA D F TADINI C C PONCE P | 2004 | Carbohydrate Polymers2004，58，4： | 1 |
| 19 | HMSPP Nanocomposite and Brazilian Bentonite Properties AfterGamma Radiation Exposure 显示文摘 | Fermino D M Parra D F Oliani W L | 2013 | Radiation Physics and Chemistry2013，84，1： | 1 |
| 20 | Differences in the deflation limb of the pressure-volume curves in acute respiratory distress syndrome from pulmonary and extrapulmonary origin显示文摘 | Albaiceta GM Taboada F Parra D | 2003 | Intensive Care Med2003，29，11： | 1 |
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