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| 1 | The characterization of astrocyte cell lines that display properities of glial scar显示文摘 | Groves AK Entwistle A Parmjit S | 1993 | Tissue Dev Biol1993，159，： | 1 |
| 2 | Expression of Transient Receptor Potential C6 Channels in Human Lung Macrophages显示文摘 | Finney-Hayward Tricia K Popa Mariana Oana Bahra Parmjit Li Su Poll Christopher T Gosling Martin Nicholson Andrew G Russell Richard E K Kon Onn Min Jarai Gabor Westwick John Barnes Peter J Donnelly Louise E | 2010 | American Journal of Respiratory Cell and Molecular Biology2010，，3： | 1 |
| 3 | Microbial production,Immobilization and applications of p - D - galactoaidase 显示文摘 | Parmjit S P Reeba P Ram S St | 2006 | Chemical Technology and Biotechnology2006，81，4： | 1 |
| 4 | Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence显示文摘 | Parmjit Jat Sophia Mowla Neil Perkins | 2013 | OncoTargets and Therapy (default)2013，，： | 1 |
| 5 | Mechanism of eutectic crystallization 显示文摘 | Rastogi R P Parmjit S B | 1964 | Journal of Physical Chemistry1964，68，9： | 1 |
| 6 | The ion channel transient receptor potential melastatin-2 does not play a role in inflammatory mouse models of chronic obstructive pulmonary disease显示文摘 | LIZ H PARMJIT B BENJAMIN C B | 2012 | Respir Res2012，13，1： | 1 |
| 7 | Nuclear DNA Amounts in Angiosperms and their Modern Uses—807 New Estimates显示文摘 | Michael D. Bennett Parmjit Bhandol Ilia J. Leitch | 2000 | Annals of Botany2000，，4： | 1 |
| 8 | Lactulose: Production, purification and potential applications显示文摘 | Parmjit S. Panesar Shweta Kumari | 2011 | Biotechnology Advances2011，，6： | 1 |
| 9 | Microbial production,immobilization and applications of β - D - galactosidase 显示文摘 | Parmjit SP Reeba P Ram SS | 2006 | Chemical Technology and Biotechnology2006，81，4： | 1 |
| 10 | Production of β-D-galactosidase from whey using Kluyveromyces marxianus 显示文摘 | Parmjit S P | 2008 | Res J Microbiol2008，3，1： | 1 |
| 11 | Direct derivation of conditionally immortal cell lines from an H-2K^b-tsA58 transgenic mouse显示文摘 | Parmjit S J Mark D N Paris A | 1991 | Proc Natl Acad Sci1991，88，： | 1 |
| 12 | Welan Gum: Microbial Production, Characterization, and Applications显示文摘 | Varinder Kaur Manav B. Bera Parmjit S. Panesar Harish Kumar J.F. Kennedy | 2014 | International Journal of Biological Macromolecules2014，，： | 1 |
| 13 | Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma显示文摘Loss of function of the von Hippel-Lindau(VHL)tumor suppressor gene is a hallmark of clear cell renal cell carcinoma(ccRCC).The importance of heterogeneity in the loss of this tumor suppressor has been under reported.To study the impact of intratumoral VHL heterogeneity observed in human ccRCC,we engineered VHL gene deletion in four RCC models,including a new primary tumor cell line derived from an aggressive metastatic case.The VHL gene-deleted(VHL-KO)cells underwent epithelial-to-mesenchymal transition(EMT)and exhibited increased motility but diminished proliferation and tumorigenicity compared to the parental VHL-expressing(VHL+)cells.Renal tumors with either VHL+or VHL-KO cells alone exhibit minimal metastatic potential.Combined tumors displayed rampant lung metastases,highlighting a novel cooperative metastatic mechanism.The poorly proliferative VHL-KO cells stimulated the proliferation,EMT,and motility of neighboring VHL+cells.Periostin(POSTN),a soluble protein overexpressed and secreted by VHL non-expressing(VHL−)cells,promoted metastasis by enhancing the motility of VHL-WT cells and facilitating tumor cell vascular escape.Genetic deletion or antibody blockade of POSTN dramatically suppressed lung metastases in our preclinical models.This work supports a new strategy to halt the progression of ccRCC by disrupting the critical metastatic crosstalk between heterogeneous cell populations within a tumor. | Junhui Hu Ping Tan Moe Ishihara Nicholas ABayley Shiruyeh Schokrpur Jeremy GReynoso Yangjun Zhang Raymond JLim Camelia Dumitras Lu Yang Steven MDubinett Parmjit SJat Jacques Van Snick Jiaoti Huang Arnold IChin Robert MPrins Thomas GGraeber Hua Xu Lily Wu | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 0 |
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