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| 1 | Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms显示文摘AIM: To investigate the role of the Wnt/β-catenin pathway in pancreatic neuroendocrine neoplasms(PanN ENs). METHODS: Tissue microarrays containing 88 PanN ENs were immunohistochemically labeled with antibodies to β-catenin, E-cadherin, adenomatous polyposis coli(APC), chromogranin and synaptophysin. One case had only metastatic tumors resected, whereas others(n = 87) received pancreatectomy with or without partial hepatectomy. Pathology slides, demographic, clinicopathologic, and follow up data were reviewed. Patients' demographics, clinicopathologic features, and immunohistochemical results from 87 primary tumors were compared between patients with low stage(stage Ⅰ/Ⅱ) and high stage(stage Ⅲ/Ⅳ) tumors. In addition, correlation of immunohistochemical results from primary tumors with disease-specific survival(DSS) was evaluated. RESULTS: Strong membranous β-catenin staining in the primary tumor was observed in all 13 stage Ⅲ/Ⅳ Pan NENs as compared to 47%(35/74) of stage Ⅰ/Ⅱtumors(P < 0.01). However, the strong membranous β-catenin staining was unassociated with tumor grade or DSS. Decreased membranous β-catenin staining was associated with decreased membranous E-cadherin labeling. Nuclear β-catenin staining was seen in 15%(2/13) of stage Ⅲ/Ⅳ Pan NENs as compared to 0%(0/74) of stage Ⅰ/Ⅱ tumors(P = 0.02). The case with metastasectomy only also showed nuclear β-catenin staining. Two of the three cases with nuclear β-catenin staining were familial adenomatous polyposis(FAP) patients. Lack of APC expression was seen in 70%(57/81) of the cases, including the 3 cases with nuclear β-catenin staining. Expression of E-cadherin and APC in primary tumor was not correlated with tumor grade, tumor stage, or disease specific survival. CONCLUSION: The Wnt/β-catenin pathway was altered in some PanN ENs, but did not Impact DSS. PanN ENs in FAP patients demonstrated nuclear β-catenin accumulation and loss of APC. | Vivian Weiss Julie Dueber Jesse P Wright Justin Cates Frank Revetta Alexander A Parikh Nipun B Merchant Chanjuan Shi | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 3 |
| 2 | Improving intermittent androgen deprivation therapy: lessons learned from basic and translational research显示文摘断断续续的雄激素剥夺治疗(IADT ) 在有 nonmetastatic 疾病的前列腺癌症病人是连续雄激素剥夺治疗(ADT ) 的一种选择。ADT 与象热闪光,性机能障碍,贫血症,疲劳,肌肉质量的损失,骨质疏松症,新陈代谢的症候群和早熟的心血管的疾病那样的众多的副作用被联系。IADT 与改进生活并且到前列腺癌症的延期前进的质量到阉割抵抗的意愿被开发。由与 ADT 相比的 IADT 的生活的稍微改进的质量的好处在多重临床的试用被表明。IADT 被注意是到在有前列腺癌症,但是在与变形前列腺癌症在病人执行的研究的生物化学的复发的病人的 ADT 的 noninferior,结果是不确定的。我们的最近的研究建议 5 个 alpha-reductase 禁止者的管理能显著地在 IADT 的离开周期期间延长当离开周期持续时间是短的时,忍受雄激素敏感的前列腺肿瘤的老鼠的幸存。这评论在动物模型和这发现进诊所的潜在的翻译在 IADT 讨论 5 alpha-reductase 抑制的幸存利益。 | Rahul A Parikh Laura E Pascal Benjamin J Davieses Zhou Wang | 2014 | Asian Journal of Andrology2014，16，4： | 2 |
| 3 | CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL. | Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed | 2018 | Cellular & Molecular Immunology2018，15，2： | 2 |
| 4 | Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomized, placebocontrolled, multicentre study (Iressa Survival Evaluation in Lung Cancer)显示文摘 | Thatcher N Chang A Parikh P | 2005 | Lancet2005，366，9496： | 1 |
| 5 | A correlation for calculating HHV from proximate analysis of solid fuels 显示文摘 | Parikh J Channiwala S A Ghosal G K | 2005 | Fuel2005，84，5： | 1 |
| 6 | Solvent free aldol condensation of propanal to 2-methylpentenal using solid base catalysts 显示文摘 | SHARMA S K PARIKH P A JASRA R V | 2007 | Journal of Molecular Catalysis A: Chemical2007，278，12： | 1 |
| 7 | Antiviral activity of ribosome-inactivating proteins in medicine显示文摘 | Parikh B A Tumer N E | 2004 | Mini Rev Med Chem2004，4，5： | 1 |
| 8 | An overview of GaN Growth Chemistry and Its Effect on Reactor Design : Application to a Planetary Radial-flow CVD System显示文摘 | Parikh R P Adomaitis R A | 2006 | Journal of Crystal Growth2006，286，： | 1 |
| 9 | Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised placebo-controlled, multicentre study (Iressa Survival Evalua tion in Lung Cancer)显示文摘 | Thatcher N Chang A Parikh P | 2005 | Lancet2005，366，： | 1 |
| 10 | Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer:results from a randomized,placebo-controlled,multicentre study (Iressa Survival Evaluation in Lung Cancer)显示文摘 | Thatcher N Chang A Parikh P | | 0，，9496： | 1 |
| 11 | Relationship among labor, bullock and tractor inputs in Pakistan agriculture 显示文摘 | Ali F Parikh A | 1992 | American Journal of Agricultural Economics1992，74，2： | 1 |
| 12 | Impact of severity of renal dysfunction on determinants of in-hospital mortality among patients undergoing percutaneous coronary intervention显示文摘 | Parikh PB Jeremias A Naidu SS | 2012 | Catheter Cardio- vasc Interv2012，80，3： | 1 |
| 13 | Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans显示文摘 | Parikh S M Mammoto T Schultz A | 2006 | PLoS Med2006，3，3： | 1 |
| 14 | The prevalence of atopic dis- orders in children with chronic otitis media with effusion显示文摘 | Alles R Parikh A Hawk L | 2001 | Pediatr Allergy Immunol2001，12，： | 1 |
| 15 | Profiling of oxidative stress in patients with inborn errors of metabolism显示文摘 | McGuire PJ Parikh A Diaz G A | 2009 | Mol Genet Metab2009，98，12： | 1 |
| 16 | Gefitinib plus best supportive are in previously treated patients with refractory advanced non-small cell lung carcinoma: results from a randomized, placebo-controlled, multicenter study 显示文摘 | Thatcher N Chang A Parikh P | 2005 | Lancet2005，366，： | 1 |
| 17 | Ultra- sonography-guided peripheral intravenous access versus traditional approaches in patients with difficult intrave- nous access显示文摘 | Costantino T G Parikh A K Satz W A | 2005 | Ann Emerg Med2005，46，5： | 1 |
| 18 | A correlation for calculating elemental composition from proximate analysis of biomass materials 显示文摘 | Parikh J Channiwala S A Ghosal G K | 2007 | Fuel2007，6，： | 1 |
| 19 | Novel distal occluder washut method for the prevention of no-reflow during stenting of saphenous vein grafts 显示文摘 | Forman ST Parikh MA | 1999 | Cathet Cardiovasc Diagn1999，47，： | 1 |
| 20 | A correlation for calculating HHV from proximate analysis of solid fuels显示文摘 | S A Channiwala G K Ghosal | 2005 | Fuel2005，84，： | 1 |
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