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| 1 | Results of intravitreal dexamethasone implant 0.7 mg (Ozurdex^(█)) in non-infectious posterior uveitis显示文摘· AIM: To evaluate the safety and efficacy of dexamethasone implant in patients with non-infectious posterior uveitis with cystoid macular edema(CME).·METHODS: Retrospective analysis of patients reports with CME secondary to non-infectious uveitis treated with dexamethasone implant. Data included type of posterior uveitis, any systemic immunosuppressive therapy, Early Treatment Diabetic Retinopathy Study(ETDRS) best-corrected visual acuity(BCVA), central macular thickness(CMT) on optical coherence tomography(OCT) and signs of intraocular inflammation at baseline and then at 2wk postoperatively and monthly thereafter. Follow-up is up to 10 mo. Any per-operative and post-operative complications were recorded.·RESULTS: Six eyes of 4 patients with CME due to non-infectious posterior uveitis treated with dexamethasone implant. Diagnosis included idiopathic panuveitis, birdshot chorioretinopathy and idiopathic intermediate uveitis. At baseline mean ETDRS BCVA was63 letters and mean CMT 556 μm at 2wk postoperatively mean ETDRS BCVA improved to 70 letters and mean CMT decreased to 329 μm. All eyes showed clinical evidence of decreased inflammation. The duration of effect of the implant was 5 to 6mo and retreatment was required in 2 eyes. Two patients required antiglaucoma therapy for increased intraocular pressures.·CONCLUSION: In patients with non-infectious posterior uveitis dexamethasone implant can be a short-term effective treatment option for controlling intraocular inflammation. | Yew Chong Yap Thomas Papathomas Ahmed Kamal | 2015 | International Journal of Ophthalmology(English edition)2015，8，4： | 2 |
| 2 | Thrombospondin peptide ABT-898 inhibits inflammation and angiogenesis in a colitis model显示文摘AIM: To evaluate the efficacy of the improvedthrombospondin mimetic peptide ABT-898 in a murine model of ulcerative colitis. METHODS: The dextran sodium sulfate(DSS) was used for the induction of colitis in both TSP-1 deficient(TSP-1-/-) and wild type(WT) mice during 7 d. While mice were receiving the DSS dissolved in the drinking water, the ABT-898 peptide was dissolved in sterile 5% glucose solution and delivered using mini pumps subcutaneously implanted. Plasma samples were analyzed for interleukin(IL)-6 by ELISA assay and colonic tissues were harvested, fixed and processed for histological evaluation. Immunohistochemistry using antibodies for the detection of CD31 and MECA in endothelial cells was performed. Inflammation was graded in colonic sections and the number of microvessels in each lesion was assessed. Activation of signal transducer and activator of transcription 3(STAT3) in colonic samples was quantified by immunohistochemistry and Western blotting using antibodies against total STAT3 and phosphorylated STAT3(p STAT3)(Ser727).RESULTS: Treatment with ABT-898 considerably diminished the inflammatory response in WT and TSP-1-/- mice(P < 0.0001 in both groups vs control). Identification of blood vessels highlighted by CD31/MECA immunohistochemistry, showed significantly reduced vessel counts in colitic lesions of WT and TSP-1-/- mice treated with ABT898(TSP-1-/- controls/TSP-1-/- treated, P = 0.0002; WT controls/WT treated, P = 0.0005). Consistently, IL-6 was significantly diminished in plasma samples of TSP-1-/- and WT treated with the peptide when compared to the control mice(P = 0.0002 and P = 0.0148, respectively). p STAT3 positive cells were quantified in WT and TSP-1-/- treated with ABT-898. A significant decrease in positive cells for p STAT3 was observed in treated mice(TSP-1-/- controls/TSP-1-/- treated, P = 0.0089; WT/WT treated, P = 0.0110). These results were confirmedby Western blotting analyses showing lower levels of p STAT3 in colitic lesions from mice treated with the peptide ABT-898.CONCLUSION: These findings indicate that the new peptide ABT-898 ameliorates inflammation and angiogenesis and might be a therapeutic alternative in IBD and inflammatory diseases. | Linda S Gutierrez Jun Ling Derek Nye Konstantina Papathomas Catherine Dickinson | 2015 | World Journal of Gastroenterology2015，21，20： | 2 |
| 3 | Assessing tsunami vulnerability, an example from Herakleio, Crete显示文摘 | PAPATHOMA M D DOMINE-HOWES ZONG | 2003 | Nature Hazards and Earth System Science2003，3，5： | 1 |
| 4 | Triazine networks modified with monofunctional reactive cyanate ester monomers 显示文摘 | Wang D W | 1992 | J Appli Polym Sci1992，44，： | 1 |
| 5 | Prognossstic Si- gnificance of marix metalloproteinanses 2 and in bladder Canleer 显示文摘 | Papathoma AS Petrakic Grigorakis A | 2000 | Anticancer Res2000，20，3： | 1 |
| 6 | hnmunohistochemical investigation of angiogenic factors in parathyroid proliferative lesions显示文摘 | LAZARIS A C TSELENI-BALAFOUTA S PAPATHOMAS T | 2006 | Eur J Endocrinol2006，154，6： | 1 |
| 7 | The use of a calcium-channel blocker, nicardipine, for severely asphyxiated newborn infants显示文摘 | Levene MI Gibson NA Fenton AC Papathoma E Barnett D | 1990 | Dev Med Child Neurol1990，32，7： | 1 |
| 8 | EBV-positive diffuse lm'ge B-cell lymphoma of the elderly 显示文摘 | Ok CY Papathomas TG Medeiros LJ | 2013 | Blood2013，122，3： | 1 |
| 9 | liquid crystalline epoxy thermals based on dihydroxymethylstilbene synthesis and characterization显示文摘 | Barelay G G Oherck Papathomas K I | 2006 | Polymer Science Part A Polym Chem2006，60，： | 1 |
| 10 | Development of conductive adhesive materials via fill aplications显示文摘 | SUNG K KANG STEPHEN L BUCHWALTER NANCY C LABIANCA J GELORME SAMPATH PURUSHOTHAMAN K PAPATHOMAS M POLIKS | 2001 | IEEE Transactions on Components and Packaging Technologies2001，24，3： | 1 |
| 11 | The Bayesian image retrieval system,PicHunter:Theory,implementation,and psychophysical experiments显示文摘 | COX I J MINKA T P PAPATHOMAS T V | 2000 | IEEE Transactions on Image Processing2000，9，1： | 1 |
| 12 | Determinants and consequences of major insulin-like growth factor components among full-term healthy neonates显示文摘 | Skalkidou A Petridou E Papathoma E | 2003 | Cancer Epidemiol Biomarkers Prev2003，12，9： | 1 |
| 13 | Pseudosarcomatous myofihroblastic lesion of the urinary bladder: A rare entity posing a diagnostic chal- lenge and therapeutic dilemma 显示文摘 | Lekas A Parasi A Papathomas TG | 2008 | Diagn Pathol2008，3，： | 1 |
| 14 | Prognostic significance of matrix metalloproteinase 2 and 9 in bladder cancer显示文摘 | Papathoma AS Petrarki C Grigorakis A | 2000 | Anticancer Res2000，20，8： | 1 |
| 15 | EBV-positive dif-fuse large B-cell lymphoma of the elderly 显示文摘 | Ok CY Papathomas TG Medeiros LJ | 2013 | Blood2013，122，3： | 1 |
| 16 | Prognostic significance of matrix metalloproteinases 2 and 9 in bladder cancer显示文摘 | PETRAKI C GRIGORAKIS A | 2000 | Anticancer Res2000，20，3： | 1 |
| 17 | Rigid-rod thermosets based on 1,3,5-triazine-linked aromatic ester segments显示文摘 | Barclay G G Ober C K Papathomas K I | 1992 | Macromolccules1992，25，： | 1 |
| 18 | The Bayesian image retrieval system,PicHunter:theory implementation and psychophysical experiments显示文摘 | Cox I Minka T Papathomas T V | 2000 | IEEE Transactions on Image Processing2000，9，1： | 1 |
| 19 | Prognostic signifi- cance of matrix metalloproteinases 2 and 9 in bladder cancer显示文摘 | Papathoma A S Petraki C Grigorakis A | 2000 | Anticancer Res2000，20，3： | 1 |
| 20 | Cytokeratin-7, cytokeratin-19, and c-Kit: Immunoreaction during the evolution stages of primary biliary cirrhosis显示文摘 | Paschalis Chatzipantelis Andreas C. Lazaris Georgia Kafiri Konstandina Papadimitriou Thomas G. Papathomas Aphrodite Nonni Efstratios S. Patsouris | 2006 | Hepatology Research2006，，3： | 1 |
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