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| 1 | Clinicopathological differences and correlations between right and left colon cancer显示文摘BACKGROUND The differences in histopathology and molecular biology between right colon cancer(RCC)and left colon cancer(LCC)were first reported in the literature by Bufill in 1990.Since then,a large number of studies have confirmed their differences in epidemiology,clinical presentation,comorbidities and biological behaviours,which may be related to the difference in prognosis and overall survival(OS)between the two groups.AIM To investigate statistically significant differences between Greek patients with LCC and RCC.METHODS The present observational study included 144 patients diagnosed with colon cancer of any stage who received chemotherapy in a Greek tertiary oncology hospital during a 2.5-year period.Clinical information,comorbidities,histopathologic characteristics and molecular biomarkers were collected from the patients’medical records retrospectively,while administered chemotherapy regimens,targeted agents,progression-free survival(PFS)periods with first-and second-line chemotherapy and OS were recorded retroactively and prospectively.Data analysis was performed with the SPSS statistical package.RESULTS Eighty-six males and 58 females participated in the study.One hundred(69.4%)patients had a primary lesion in the left colon,and 44(30.6%)patients had a primary lesion in the right colon.Patients with RCC were more likely to display anaemia than patients with LCC[odds ratio(OR)=3.09],while LCC patients were more likely to develop rectal bleeding(OR=3.37)and a feeling of incomplete evacuation(OR=2.78)than RCC patients.Considering comorbidities,RCC patients were more likely to suffer from diabetes(OR=3.31)and coronary artery disease(P=0.056)than LCC patients.The mucinous differentiation rate was higher in the right-sided group than in the left-sided group(OR=4.49),as was the number of infiltrated lymph nodes(P=0.039),while the percentage of high-grade differentiation was higher in the group of patients with left-sided colon cancer than in RCC patients(OR=2.78).RAS wild-type patients who received anti-epidermal growth factor receptor(EGFR):Treatment experienced greater benefit(PFS:16.5 mo)than those who received anti-vascular endothelial growth factor treatment(PFS:13.7 mo)(P=0.05),while among RAS wild-type patients who received anti-EGFR treatment,LCC patients experienced greater benefit(PFS:15.8 mo)than the RCC subgroup(PFS:5.5 mo)in the first-line chemotherapy setting(P=0.034).BRAF-mutant patients had shorter PFS(9.3 mo)than BRAF wild-type patients(14.5 mo)(P=0.033).RCC patients showed a shorter tumour recurrence period(7.7 mo)than those with LCC(14.5 mo)(P<0.001),as well as shorter(OS)(58.4 mo for RCC patients;82.4 mo for LCC patients)(P=0.018).CONCLUSION RCC patients present more comorbidities,worse histological and molecular characteristics and a consequently higher probability of tumour recurrence,poor response to targeted therapy and shorter OS than LCC patients. | Ioannis Kalantzis Afroditi Nonni Kitty Pavlakis Eumorphia-Maria Delicha Konstantinos Miltiadou Christos Kosmas Nikolaos Ziras Konstantinos Gkoumas Harikleia Gakiopoulou | 2020 | World Journal of Clinical Cases2020，8，8： | 4 |
| 2 | Routine modified D2 lymphadenectomy performance in pT1-T2N0 gastric cancer显示文摘AIM:To evaluate routine modified D2 lymphadenectomy in gastric cancer,based on immunohistochemically detected skip micrometastases in levelⅡlymph nodes. METHODS:Among 95 gastric cancer patients who were routinely submitted to curative modified D2 lymphadenectomy,from January 2004 to December 2008,32 were classified as pN0.All levelⅠlymph nodes of these 32 patients were submitted to immunohistochemistry for micrometastases detection. Patients in whom micrometastases were detected in the levelⅠlymph node stations(n=4)were excluded from further analysis.The levelⅡlymph nodes of the remaining 28 patients were studied immunohistochemically for micrometastases detection and constitute the material of the present study. RESULTS:Skip micrometastases in the levelⅡlymph nodes were detected in 14%(4 out of 28)of the patients. The incidence was further increased to 17%(4 out of24)in the subgroup of T1-2 gastric cancer patients.All micrometastases were detected in the No.7 lymph node station.Thus,the disease was upstaged from stageⅠA toⅠB in one patient and from stageⅠB toⅡin three patients. CONCLUSION:In gastric cancer,true R0 resection may not be achieved without modified D2 lymphadenectomy. Until D2+/D3 lymphadenectomy becomes standard, modified D2 lymphadenectomy should be performed routinely. | John Griniatsos Hara Gakiopoulou Eugenia Yiannakopoulou Nikoletta Dimitriou Gerasimos Douridas Afrodite Nonni Theodoros Liakakos Evangelos Felekouras | 2009 | World Journal of Gastroenterology2009，15，44： | 3 |
| 3 | CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation 显示文摘 | Jones C Nonni A V Fulford L | 2001 | Br J Cancer2001，85，3： | 1 |
| 4 | Tau is endogenously nitrated in mouse brain:identification of a tyrosine residue modified in vivo by NO显示文摘 | Nonnis S Cappelletti G Taverna F | 2008 | Neurochem Res2008，33，3： | 1 |
| 5 | Genes regulating the serotonin metabolic pathway in the brain stem and their role in the etiopathogenesis of the sudden infant death syndrome显示文摘 | Nonnis Marzano F Maldini M Filonzi L | 2008 | Genomics2008，91，6： | 1 |
| 6 | CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation显示文摘 | Jones C Nonni AV Fulford L | 2001 | BrJ Cancer2001，85，3： | 1 |
| 7 | Mammary epidermoid inclusioncysts after wide-core needle biopsies显示文摘 | Davies JD Nonni A D'Costa HF | 1997 | Histopathology1997，31，： | 1 |
| 8 | Comparison of molecular markers expression in vacuum - assisted biopsies and surgical specimens of human breast carcinomas 显示文摘 | ZAGOUR1 F SERGENTANIS T N NONNI A | 2010 | Pathol Res Pract2010，206，1： | 1 |
| 9 | Late onset familial Hallervorden - Spatz disease: MR findings in two sisters 显示文摘 | Ambrosetto P Nonni R Bacci A | 1992 | AJNR1992，13，3： | 1 |
| 10 | Vacuum-assisted breast biopsy: The value and limitations of cores with microcalcifications显示文摘 | Zagouri F Sergentanis TN Nonni A | 2007 | Pathol Res Pract2007，203，8： | 1 |
| 11 | Comparison of molecular markers expression in vacuum-assisted biopsies and surgical specimens of human breast carcinomas 显示文摘 | Zagouri F Sergentanis TN Nonni A | 2010 | Pathol Res Pract2010，206，1： | 1 |
| 12 | Comparison of molecular markers expression in vacuum-assisted biopsies and surgical specimens of human breast carcinomas显示文摘 | Zagouri F Sergentanis TN Nonni A | | 0，，01： | 1 |
| 13 | Cytokeratin-7, cytokeratin-19, and c-Kit: Immunoreaction during the evolution stages of primary biliary cirrhosis显示文摘 | Paschalis Chatzipantelis Andreas C. Lazaris Georgia Kafiri Konstandina Papadimitriou Thomas G. Papathomas Aphrodite Nonni Efstratios S. Patsouris | 2006 | Hepatology Research2006，，3： | 1 |
| 14 | Cytokeratin-7, cytokeratin-19, and c-Kit: Immunoreaction during the evolution stages of primary biliary cirrhosis显示文摘 | Paschalis Chatzipantelis Andreas C. Lazaris Georgia Kafiri Konstandina Papadimitriou Thomas G. Papathomas Aphrodite Nonni Efstratios S. Patsouris | 2006 | Hepatology Research2006，，3： | 1 |
| 15 | Vacuum-assisted breast biopsy:The value and limitations of cores with microcalcifications显示文摘 | Zagouri F Sergentanis TN Nonni A | | 0，，08： | 1 |
| 16 | Psycho-social sources of stress and burnout in schools : research on a sample of Italian teachers显示文摘 | Pedditzi ML Nonnis M | 2014 | Med Lav2014，105，1： | 1 |
| 17 | Tyrosine nitration is a novel post-translationalmodification occurring on the neural intermediate filament pro-tein peripherin显示文摘 | Tedeschi G Cappelletti G Nonnis S Taverna F Negri A Ron-chi C | 2007 | Neurochem Res2007，32，： | 1 |
| 18 | Comparison of molecular markers expression in vacuum-assisted biopsies and surgical specimens of human breast carcinomas显示文摘 | Zagouri F Sergentanis TN Nonni A | 2010 | Pathol Res Pract2010，206，1： | 1 |
| 19 | CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation显示文摘 | Jones C Nonni AV Fulford L | 2001 | Br J Cancer2001，85，3： | 1 |
| 20 | Psycho-social sources of stress and burnout in schools: research on a sample of Italian teachers 显示文摘 | Pedditzi ML Nonnis M | 2014 | La Medicina Del Lavoro2014，105，1： | 1 |
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