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| 1 | Ursodeoxycholic acid as adjuvant treatment to phototherapy for neonatal hyperbilirubinemia:a systematic review and meta‑analysis显示文摘Background Neonatal hyperbilirubinemia is observed in most newborns,and 5–15%of neonates require phototherapy.Phototherapy is efective but often prolongs hospitalization and has both short-term and potential long-term harms.The aim of this systematic review and meta-analysis was to evaluate the role of ursodeoxycholic acid(UDCA)combined with phototherapy in neonatal hyperbilirubinemia.Methods A literature search was conducted on September 1,2021;590 studies were screened,and 17 full texts were assessed by two authors.We included randomized controlled trials with or without placebo intervention.Primary outcomes were changes in total bilirubin levels at 24 hours and phototherapy duration.We calculated mean diferences with 95%confdence intervals(CI).Results Six studies with 880 neonates were included.Of these studies,only two used a placebo-controlled double-blinded design.The overall risk of bias was high in one and moderate in four of the included studies.The mean decrease in the total bilirubin level during the frst 24 hours was 2.06 mg/dL(95%CI 0.82–3.30;six studies)greater in the UDCA treatment group.The phototherapy duration was 19.7 hours(95%CI 10.4–29.1;fve studies)shorter in the UDCA treatment group.Conclusions We found low-quality evidence that UDCA as an adjuvant to phototherapy seems to decrease total bilirubin faster and shorten phototherapy duration compared to standard treatment.Further studies are needed to confrm the efcacy,acute and long-term outcomes,and safety before implementing UDCA as an adjuvant to phototherapy in neonatal hyperbilirubinemia. | Ilari Kuitunen Panu Kiviranta Ulla Sankilampi Marjo Renko | 2022 | World Journal of Pediatrics2022，18，9： | 2 |
| 2 | Groups and neural networks based stream flow data infilling procedures显示文摘 | KHALIL M PANU U S LENNOX W C | 2001 | Journal of Hydrology2001，241，： | 1 |
| 3 | The metabolic syndome-a multifaced disease显示文摘 | Mota M Panus C Mota E | 2004 | Rom J Intern Med2004，42，2： | 1 |
| 4 | Estimation of missing streamflow data using principles of chaos theory显示文摘 | Elshorbagy A Simonovic S P Panu U S | 2002 | Journal of Hydrology2002，255，： | 1 |
| 5 | Towards complete im- pregnation of wood chips with aqueous solutions Part 1 : A retrospec- tive and critical evaluation of the penetration process 显示文摘 | Sergey Malkov Panu Tikka Johan Gullichsen | 2003 | Paperi ja Puu2003，85，8： | 1 |
| 6 | Challenges in drought research: Some perspectives and future directions显示文摘 | Panu U S Sharma T C | 2002 | Hydrological Sciences Journal2002，47，1： | 1 |
| 7 | Govern- mental and auditing in Thailand: anoverview and some suggestions for improvernent显示文摘 | Laurie J Henry and Panu Attavit Kamtom | 1999 | The International Journal of Accounting1999，，： | 1 |
| 8 | Block Copolymer Micelles with Acid - Labile Ortho Ester Side- Chains : Synthesis, Char- acterization, and Enhanced Drug Delivery to Human Glioma Cells显示文摘 | Tang R Ji W H Panus D | 2011 | Journal of Controlled Release2011，151，1： | 1 |
| 9 | Inorganic hollow nanotube aerogels by atomic layer deposition onto native nanocellulose tem- plates显示文摘 | Korhonen J T Panu H Jari M | 2011 | Acs Nano2011，5，3： | 1 |
| 10 | Wavelet transform-based stress-time history editing of horizontal axis wind tur bine blades显示文摘 | PANU PRATUMNOPHARAT PAK SING LEUNG RICHARD S COURT | | 0，，： | 1 |
| 11 | Regulation of xanthine dehydrogenase and xanthine oxidase activity by hypoxia显示文摘 | Poss W B Huecksteadt T P Panus P C | 1996 | Am J Physiol Lung Cell Mol Physiol1996，270，： | 1 |
| 12 | Regulation of xan- thine dehydrogenase and xanthine oxidase activity by hypoxia 显示文摘 | Poss WB Huecksteadt TP Panus PC | 1996 | Am JPhysiol1996，270，61： | 1 |
| 13 | Multimodality imaging of neoplastic and nonneoplastic solid lesions of the pancreas显示文摘 | Low G Panu A Millo N | 2011 | Radiographics2011，31，4： | 1 |
| 14 | Estimation of Missing Streamflow Data Using Principles of Chaos Theory显示文摘 | Elshorbagy A Simonovic S P Panu U S | 2002 | Journal of Hydrology2002，255，： | 1 |
| 15 | The metabolic syndrome-a multifaced disease 显示文摘 | Mota M Panus C Mota E | 2004 | Rom J Intern Med2004，42，2： | 1 |
| 16 | Multimodality imaging of neoplastic and nonneop- lastic solid lesions of the pancreas显示文摘 | Low G Panu A Millo N | 2011 | Radiographics2011，31，4： | 1 |
| 17 | Prediction of hydrological drought durations based on Markov chains: case of the Canadian prairies显示文摘 | T.C. Sharma U.S. Panu | 2012 | Hydrological Sciences Journal2012，，4： | 1 |
| 18 | Effectiveness, safety, and drug sustainability of biologics in elderly patients with inflammatory bowel disease: A retrospective study显示文摘BACKGROUND Biologic therapy resulted in a significant positive impact on the management of inflammatory bowel disease(IBD) however data on the efficacy and side effects of these therapies in the elderly is scant.AIM To evaluate retrospectively the drug sustainability, effectiveness, and safety of the biologic therapies in the elderly IBD population.METHODS Consecutive elderly(≥ 60 years old) IBD patients, treated with biologics [infliximab(IFX), adalimumab(ADAL), vedolizumab(VDZ), ustekinumab(UST)] followed at the McGill University Inflammatory Bowel Diseases Center were included between January 2000 and 2020.Efficacy was measured by clinical scores at 3, 6-9 and 12-18 mo after initiation of the biologic therapy. Patients completing induction therapy were included. Adverse events(AEs) or serious AE were collected during and within three months of stopping of the biologic therapy.RESULTS We identified a total of 147 elderly patients with IBD treated with biologicals during the study period, including 109 with Crohn’s disease and 38 with ulcerative colitis. Patients received the following biologicals: IFX(28.5%), ADAL(38.7%), VDZ(15.6%), UST(17%). The mean duration of biologic treatment was 157.5(SD = 148) wk. Parallel steroid therapy was given in 34% at baseline,19% at 3 mo, 16.3% at 6-9 mo and 6.5% at 12-18 mo. The remission rates at 3, 6-9 and 12-18 mo were not significantly different among biological therapies. Kaplan-Meyer analysis did not show statistical difference for drug sustainability(P = 0.195), time to adverse event(P = 0.158) or infection rates(P = 0.973) between the four biologics studied. The most common AEs that led to drug discontinuation were loss of response, infusion/injection reaction and infection.CONCLUSION Current biologics were not different regarding drug sustainability, effectiveness, and safety in the elderly IBD population. Therefore, we are not able to suggest a preferred sequencing order among biologicals. | Gustavo Drugg Hahn Jean-Frederic LeBlanc Petra Anna Golovics Panu Wetwittayakhlang Abdulrahman Qatomah Anna Wang Levon Boodaghians Jeremy Liu Chen Kiow Maryam Al Ali Gary Wild Waqqas Afif Alain Bitton Peter Laszlo Lakatos Talat Bessissow | 2022 | World Journal of Gastroenterology2022，28，33： | 1 |
| 19 | Ultrasound-guided aspi- ration and injection of an intraneural ganglion cyst of the com- mon peroneal nerve显示文摘 | Liang T Panu A Crowther S | 2013 | HSS J2013，9，3： | 1 |
| 20 | Transdemal iontophoretic delivery of Ketoprofen through humancadaver skin and in humans显示文摘 | Panus PC Campbell J Shirisshkumar | 1997 | Controlled Release1997，44，23： | 1 |
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