|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Survival outcomes of right-lobe living donor liver transplantation for patients with high Model for End-stage Liver Disease scores显示文摘BACKGROUND: Controversy exists over whether living donor liver transplantation (LDLT) should be offered to patients with high Model for End-stage Liver Disease (MELD) scores. This study tried to determine whether a high MELD score would result in inferior outcomes of right-lobe LDLT. METHODS: Among 411 consecutive patients who received right-lobe LDLT at our center, 143 were included in this study. The patients were divided into two groups according to their MELD scores: a high-score group (MELD score ≥25; n=75) and a low-score group (MELD score <25; n=68). Their demographic data and perioperative conditions were compared. Univariable and multivariable analyses were performed to identify risk factors affecting patient survival. RESULTS: In the high-score group, more patients required preoperative intensive care unit admission (49.3% vs 2.9%; P<0.001), mechanical ventilation (21.3% vs 0%; P<0.001), or hemodialysis (13.3% vs 0%; P=0.005); the waiting time before LDLT was shorter (4 vs 66 days; P<0.001); more blood was transfused during operation (7 vs 2 units; P<0.001); patients stayed longer in the intensive care unit (6 vs 3 days; P<0.001) and hospital (21 vs 15 days; P=0.015) after transplantation;more patients developed early postoperative complications (69.3% vs 50.0%; P=0.018); and values of postoperative peak blood parameters were higher. However, the two groups had comparable hospital mortality. Graft survival and patient overall survival at one year (94.7% vs 95.6%; 95.9% vs 96.9%), three years (91.9% vs 92.6%; 93.2% vs 95.3%), and five years (90.2% vs 90.2%; 93.2% vs 95.3%) were also similar between the groups. CONCLUSIONS: Although the high-score group had signifi-cantly more early postoperative complications, the two groups had comparable hospital mortality and similar satisfactory rates of graft survival and patient overall survival. Therefore, a high MELD score should not be a contraindication to right-lobe LDLT if donor risk and recipient benefit are taken into full account. | Kenneth SH Chok See Ching Chan James YY Fung Tan To Cheung Albert CY Chan Sheung Tat Fan Chung Mau Lo | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 6 |
| 3 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 4 | Adrenomedullin is both proinflammatory and anti-inflammatory:its effects on gene expression and secretion of cytokines and macrophage migration inhibitory factor in NR8383 macrophage cell line显示文摘 | Wong LY Cheung BM Li YY | 2005 | Endocrinology2005，146，3： | 1 |
| 5 | Incidence ofneurosensory deficits and recovery after lower third molarsurgery:a prospective clinical study of 4338 cases显示文摘 | Cheung LK Leung YY Chow LK | 2010 | IntJ Oral Maxillofac Surg2010，39，4： | 1 |
| 6 | Psuedodefect of the capitellum:potential MR imaging pitfall显示文摘 | Rosenberg ZS Beltran J Cheung YY | | 0，，： | 1 |
| 7 | Incidence of neurosensory deficits and recovery after lower third molar surgery: a prospective clinical study of 4338 cases 显示文摘 | Cheung LK Leung YY Chow LK | 2010 | Int J Oral Maxillofac Surg2010，39，4： | 1 |
| 8 | Safety of coronectomy versus excision of wis- dom teeth:a randomized controlled triM显示文摘 | Leung YY Cheung LK | 2009 | Oral Surg Oral Med O- ral Patbol Oral Radiol Endod2009，108，6： | 1 |
| 9 | Impaired neutrophil activity and increased susceptibility tobacterial infection in mice lacking glucose-6-phosphatase-beta显示文摘 | Cheung YY Kim SY Yiu WH Pan CJ Jun HS Ruef RA etal | 2007 | J Clin Invest2007，117，3： | 1 |
| 10 | Concomitant pulmonary and mediastinal sclerosing hemangioma显示文摘 | Lu YY NG SH Cheung YC | 2004 | BJR2004，77，2： | 1 |
| 11 | Safety of coronectomy versus excision of wisdom teeth:a randomized controlled trial显示文摘 | Leung YY Cheung LK | | 0，，06： | 1 |
| 12 | Case report:Concomitant pulmonary and mediastinal sclerosing haemangiomas显示文摘 | LU YY Ng SH Cheung YC | 2004 | Br J Radiol2004，77，917： | 1 |
| 13 | Surgical ciliated cysts may mimic radicular cysts or residual cysts of maxilla: report of 3 cases显示文摘 | Leung YY Wong WY Cheung LK | 2012 | J Oral Maxillofac Surg2012，70，4： | 1 |
| 14 | Adrenomedullin is both proinflammatory and antiinflammatory: its effects on gene ex- pression and secretion of cytokines and macrophage migration inhibitory factor in NR8383 macrophage cell line显示文摘 | Wong LY Cheung BM Li YY | 2005 | Endocri- nology2005，146，3： | 1 |
| 15 | Differential induction of adrenomedullin,interleukins and tumour necrosis factoralpha by lipopolysaccharide in rat tissues in vivo显示文摘 | Li YY Wong LY Cheung BM | 2005 | Clin Exp Pharmacol Physiol2005，32，12： | 1 |
| 16 | Adrenomedullin is both proinflammatory and antiinflammatory:its effects on gene expression and secretion of cytokines and macrophage migration inhibitory factor in NR8383 macrophage cell line显示文摘 | Wang LY Cheung BM li YY | 2005 | Endocrinology2005，146，3： | 1 |
| 17 | Safety of coroneetomy versus excision of wisdom teeth: a randomized controlled trial 显示文摘 | Leung YY Cheung LK | 2009 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2009，108，6： | 1 |
| 18 | Coronectomy of the lower third molar issafe within the first 3 years 显示文摘 | Leung YY Cheung LK | 2012 | J Oral Maxillofac Surg2012，70，7： | 1 |
| 19 | Incidence of neurosensory deficits and recovery after lower third molar surgery: a prospective clinical study of 4338 cases 显示文摘 | CHEUNG LK LEUNG YY CHOW LK | 2010 | Int J Oral Maxillofac Surg2010，39，4： | 1 |
| 20 | Adrenomedullin is both proinflammatory and antiinflammatory: its effects on gene expression and secretion of cytokines and macrophage migration inhibitory factor in NR8383 macrophage cell line 显示文摘 | Wong LY Cheung BM Li YY | 2005 | Endocrinology2005，146，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员