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| 1 | Transplantation of human bone marrow-derived mesenchymal stem cells transfected with ectodysplasin for regeneration of sweat glands显示文摘有严重完整厚度的灼伤损害的背景病人受不了他们的无能因为完全的 destructed 汗腺不能被改革,通过排汗维持身体温度。因为他们的容易的纯化和 multipotency,骨头导出髓的间充质的干细胞(BM-MSCs ) 为房间治疗代表理想的干细胞来源。在这研究,我们试图导致人的 BM-MSCs 通过 ectodysplasin (EDA ) 为汗腺新生区分进汗腺房间基因 transfection。EDA 和 EDA 受体(EDAR ) 的动态表示第一在胚胎学的开发期间在汗腺形成被观察的方法。在有 EDA 表示向量的 transfection 以后,人的 BM-MSCs 被移植进灼伤动物模型的受伤区域。汗腺的新生被排汗测试和 immunohistochemical 分析识别。结果 EDA 和 EDAR 的内长的表示在人的胎儿的皮肤与汗腺开发相关。在 EDA transfection 以后, BM-MSC 获得了 sweat-gland-cell 显型,由流动 cytometry 分析由他们汗腺标记的表示证实了。染色的 Immunohistochemical 揭示了一显著地到在烫伤的爪的汗腺的新生的 EDA-transfected BM-MSCs 的贡献。为为与 EDA-transfected BM-MSCs 对待的爪的排汗测试的积极的率比与 BM-MSCs 或 EDA 表示向量(P 0.05 ) 对待的那些显著地高。我们的结果在汗腺的发展证实了 EDA 的重要角色的结论。有 EDA 的 BM-MSCs transfected 显著地改进了汗腺新生。这研究为受伤皮肤和它的附器的修理和新生建议修改 EDA 的 MSC 的潜在的申请。 | CAI Sa PAN Yu HAN Bing SUN Tong-zhu SHENG Zhi-yong FU Xiao-bing | 2011 | Chinese Medical Journal2011，，15： | 18 |
| 2 | Formation mechanism of propagated sensation along the meridians,as verified by cortical somatosensory-evoked potential topographic maps显示文摘The peripheral driver stimulating theory states that as a driver passes along a certain meridian during acupuncture;the driver provokes nerve sense devices along the meridian,resulting in the nerve impulse entering the central nervous system.Accordingly,volunteers have reported propagated sensations along the meridians (PSM).The present study was designed to utilize a cortical somatosensory-evoked potential (CSEP) topographic map for determining whether stimulation expansion occurs in somatosensory area I when sensation was provoked in individuals with obvious PSM.The sensation was blocked by mechanical compression,and the sensation was imitated in individuals without PSM.Results revealed a red,high-potential signal in the representative area of the lower limbs in individuals with obvious PSM symptoms when the Gall Bladder Meridian (GBM) sensation passed to the head and face.This representative area was near the middle line of the CSEP topographic map,and a red,high-potential signal,which jumps over the representative area of the upper limbs,also appeared in the representative face area,which was at the external region of the CSEP topographic map.However,in individuals exhibiting no PSM,only a red high-potential signal appeared in the representative lower limb area.When Hegu (LI 4) was stimulated in individuals without PSM,an obvious evoked response appeared only in the representative upper limb area.However,when Hegu was stimulated in individuals exhibiting PSM,the response area was larger in the representative upper limb area and extended to the representative face area.When Guangming (GB 37) was stimulated in PSM individuals,the face representation response disappeared and was confined to a foot representation of the somatosensory area I when PSM was blocked by mechanical pressure.Results suggested that mechanical compression blocked PSM,and corresponding changes were exhibited in the CSEP topographic map.These results provide compelling evidence for the hypothesis that peripheral driver stimulation is the key element in producing PSM. | Jinsen Xu Xiaohua Pan Shuxia Zheng Xianglong Hu Zheyan Sa | 2011 | Neural Regeneration Research2011，6，6： | 3 |
| 3 | A Redox-based Mechanism for the Neuroprotective and Neurodestructive Effects of Nitric Oxide and Related Nitrosocompounds显示文摘 | LIPTON SA CHOI YB PAN ZH | 1993 | Nature1993，364，6438： | 1 |
| 4 | Attenuation correction of PET images with respiration-averaged CT images in PET/CT显示文摘 | Pan T Mawlawi O Nehmeh SA | 2005 | J Nucl Med2005，46，9： | 1 |
| 5 | A redox based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso compounds显示文摘 | Lipton SA Choi YB Pan ZI | 1993 | Nature1993，364，： | 1 |
| 6 | A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds显示文摘 | LIPTON SA CHOI YB PAN ZH | 1993 | Nature1993，364，6438： | 1 |
| 7 | A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitrosocompounds 显示文摘 | Lipton SA Choi YB Pan ZH | 1993 | Nature1993，364，6438： | 1 |
| 8 | Perturbed skeletal muscle insulin signaling in the adult female intra - uterine growth restricted B rat显示文摘 | Oak SA Tran C Pan G | 2006 | Am J Physiol Endocrinol Metab2006，290，6： | 1 |
| 9 | Perturbed skeletal muscle insulin signaling in the adult female intrauterine growth - restricted rat显示文摘 | Oak SA Tran C Pan G | 2006 | Am J Physiol Endocrinol Metab2006，290，6： | 1 |
| 10 | A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds 显示文摘 | Lipton SA Choi YB Pan ZH | 1993 | Nature1993，364，6438： | 1 |
| 11 | Calmodulin-dependent protein kinase kinase-is an alternative upstream ki- nase for AMP-activated protein kinase显示文摘 | Hawley SA Pan DA Mustard KJ | | 0，，01： | 1 |
| 12 | A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds 显示文摘 | Choi YB Pan ZH | 1993 | Nature1993，364，6438： | 1 |
| 13 | Informatics in radiology:GridCAD:grid-based computer-aided detection system显示文摘 | Pan TC Gurcan MN Langella SA | 2007 | Radiographics2007，27，3： | 1 |
| 14 | Quantitation of respiratory motion during 4D-PET-CT acquisition显示文摘 | Nehmeh SA Erdi YE Pan T | 2004 | Med Phys2004，31，6： | 1 |
| 15 | A redox-based mechanism for the neuroprotective and neurodestructive effects of nitricoxide and related nitro so-compounds 显示文摘 | Lipton SA Choi YB Pan ZH | 1993 | Nature1993，364，： | 1 |
| 16 | Moderate hypothermia during aortic arch surgery is associated with reduced risk of early mortality显示文摘 | Tsai JY Pan W Lemaire SA | 2013 | J Thorac Cardiovasc Surg2013，146，3： | 1 |
| 17 | A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitric compounds显示文摘 | Lipton SA Choi YB Pan ZH | 1993 | Nature1993，364，： | 1 |
| 18 | A redox-based mechanism for the neuroprotectiv and neurodestructive effects of nitric oxide and related nitrosocompounds显示文摘 | Lipton SA Choi YB Pan ZH | 1993 | Nature1993，364，6： | 1 |
| 19 | Calmodulin-dependent protein kinase kinase-b is an alternative upstream kinase for AMP-activated protein kinase显示文摘 | Hawley SA Pan DA Mustard K J | 2005 | Cell Metab2005，2，1： | 1 |
| 20 | Calmodulin-de- pendent protein kinase kinase-beta is an ahemative up- stream kinase for AMP-activated protein kinase 显示文摘 | Hawley SA Pan DA Mustard K J | 2005 | Cell Metab2005，2，1： | 1 |
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