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| 1 | Doublely-doped Mg-Al-Ce-V_(2)O_(7)^(4-)LDH composite film on magnesium alloy AZ31 for anticorrosion显示文摘A doublely-doped layered double hydroxide(LDH)film was produced on an anodized magnesium alloy AZ31.The Ce-doped Mg-Al LDH film was prepared by in-situ hydrothermal treatment method,and the intercalation of vanadate was realized by ion-exchange reaction.The structure,morphology and composition of as-prepared LDH film were investigated by X-ray diffractometer,field-emission scanning electronic microscope and energy dispersive spectrometry.Results indicated that a uniform and compact LDH film was formed and the intercalation of Ce^(3+)and vanadate would change the crystal structure of LDHs.The results of the potentiodynamic polarization,electrochemical impedance spectra,hydrogen evolution and corrosion weight loss tests showed the Ce^(3+)and vanadate anions significantly improve the impedance of LDH film,and the active double-doped LDH film could effectively protect the magnesium substrate from corrosion. | Liang Wu Xingxing Ding Zhicheng Zheng Aitao Tang Gen Zhang Andrej Atrens Fusheng Pan | 2021 | Journal of Materials Science & Technology2021，，5： | 7 |
| 2 | Selective conversion of syngas to propane over ZnCrO_x-SSZ-39 OX-ZEO catalysts显示文摘Oxide-Zeolite(OX-ZEO) bifunctional catalyst design concept has been exemplified in several processes to direct conversion syngas to value-added chemicals and fuels such as mixed light olefins, ethylene, aromatics and gasoline.Herein we demonstrate that the product can be steered toward liquefied petroleum gas(LPG) with a selectivity up to 89% in hydrocarbons especially propane selectivity reaching 80% at CO conversion of 63% using ZnCrOx-H-SSZ-39 catalyst.Interestingly, the quantity of the acid sites of SSZ-39 does not influence obviously the hydrocarbon distribution but the strength is crucial for selective formation of propane.This finding provides an alternative route of LPG synthesis from a variety of carbon resources via syngas. | Gen Li Feng Jiao Dengyun Miao Yong Wang Xiulian Pan Toshiyuki Yokoi Xiangju Meng Feng-Shou Xiao Andrei-Nicolae Parvulescu Ulrich Müller Xinhe Bao | 2019 | Journal of Energy Chemistry2019，28，9： | 6 |
| 3 | MAP4K4 induces early blood-brain barrier damage in a murine subarachnoid hemorrhage model显示文摘Sterile-20-like mitogen-activated protein kinase kinase kinase kinase 4(MAP4 K4)is expressed in endothelial cells and activates inflammatory vascular damage.Endothelial cells are important components of the blood-brain barrier.To investigate whether MAP4 K4 plays a role in the pathophysiology of subarachnoid hemorrhage,we evaluated the time-course expression of MAP4 K4 after subarachnoid hemorrhage.A subarachnoid hemorrhage model was established using the intravascular perforation method.The model mice were assigned to four groups:MAP4 K4 recombinant protein,scramble small interfering RNA,and MAP4 K4 small interfering RNA were delivered by intracerebroventricular injection,while PF-06260933,a small-molecule inhibitor of MAP4 K4,was administrated orally.Neurological score assessments,brain water assessments,Evans blue extravasation,immunofluorescence,western blot assay,and gelatin zymography were performed to analyze neurological outcomes and mechanisms of vascular damage.MAP4 K4 expression was elevated in the cortex at 24 hours after subarachnoid hemorrhage,and colocalized with endothelial markers.MAP4 K4 recombinant protein aggravated neurological impairment,brain edema,and blood-brain barrier damage;upregulated the expression of phosphorylated nuclear factor kappa B(p-p65)and matrix metalloproteinase 9(MMP9);and degraded tight junction proteins(ZO-1 and claudin 5).Injection with MAP4 K4 small interfering RNA reversed these effects.Furthermore,administration of the MAP4 K4 inhibitor PF-06260933 reduced blood-brain barrier damage in mice,promoted the recovery of neurological function,and reduced p-p65 and MMP9 protein expression.Taken together,the results further illustrate that MAP4 K4 causes early blood-brain barrier damage after subarachnoid hemorrhage.The mechanism can be confirmed by inhibiting the MAP4 K4/NF-κB/MMP9 pathway.All experimental procedures and protocols were approved by the Experimental Animal Ethics Committee of General Hospital of Northern Theater Command(No.2018002)on January 15,2018. | Zheng Zou Yu-Shu Dong Dong-Dong Liu Gen Li Guang-Zhi Hao Xu Gao Peng-Yu Pan Guo-Biao Liang | 2021 | Neural Regeneration Research2021，16，2： | 5 |
| 4 | Clinical experience of 3T intraoperative magnetic resonance imaging integrated neurosurgical suite in Shanghai Huashan Hospital显示文摘 | QIU Tian-ming YAO Cheng-jun WU Jin-song PAN Zhi-guang ZHUANG Dong-xiao XU Gen ZHU Feng-ping LU Jun-feng GONG Xiu ZHANG Jie YANG Zhong SHI Jian-bin HUANG Feng-ping MAO Ying ZHOU Liang-fu | 2012 | Chinese Medical Journal2012，，24： | 3 |
| 5 | The interferon-stimulated exosomal hACE2 potently inhibits SARS-CoV-2 replication through competitively blocking the virus entry显示文摘Since the outbreak of coronavirus disease 2019(COVID-19),it has become a global pandemic.The spike(S)protein of etiologic severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specifically recognizes human angiotensin-converting enzyme 2(hACE2)as its receptor,which is recently identified as an interferon(IFN)-stimulated gene.Here,we find that hACE2 exists on the surface of exosomes released by different cell types,and the expression of exosomal hACE2 is increased by IFNα/β treatment.In particular,exosomal hACE2 can specifically block the cell entry of SARS-CoV-2,subsequently inhibit the replication of SARS-CoV-2 in vitro and ex vivo.Our findings have indicated that IFN is able to upregulate a viral receptor on the exosomes which competitively block the virus entry,exhibiting a potential antiviral strategy. | Junsong Zhang Feng Huang Baijin Xia Yaochang Yuan Fei Yu Guanwen Wang Qianyu Chen Qian Wang Yuzhuang Li Rong Li Zheng Song Ting Pan Jingliang Chen Gen Lu Hui Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 6 | In-situ LDHs growth on PEO coatings on AZ31 magnesium alloy for active protection:Roles of PEO composition and conversion solution显示文摘In this work,plasma electrolytic oxidation(PEO)coatings were produced on magnesium alloy AZ31 in aluminate,silicate and phosphate-based electrolytes,and followed by hydrothermal treatments in order to synthesis layered double hydroxides(LDHs)based nanocontainers.LDHs synthesis was done in three different growth solutions(deionized water,sodium nitrate and aluminum nitrate containing solution).In frame of this work it was shown,that it was difficult to form LDHs on Si-based PEO coating,due to more stable silicate phases in comparison with aluminate and phosphate phases in respective PEO coatings.The obtained hybrid LDH/PEO coatings were characterized using SEM,EDS and GDOES,and then the corrosion protection was further investigated by EIS.Based on the obtained results,it was confirmed that,the hydrothermal treatments in Al^(3+)containing solution played an important role on overall corrosion resistance for phosphate and silicate-based PEO coatings,but not for Al-based PEO coatings. | Gen Zhang Liang Wu Maria Serdechnova Aitao Tang Cheng Wang Carsten Blawert Fusheng Pan Mikhail L.Zheludkevich | 2023 | Journal of Magnesium and Alloys2023，11，7： | 1 |
| 7 | Effect of biochar amendment on maize yield and greenhouse gas e- missions from a soil organic Carbon poor calcareous loamy soil from Central China Plain 显示文摘 | ZHANG A - feng LIU Yu - ming PAN Gen - xing | 2012 | Plant and Soil2012，351，12： | 1 |
| 8 | Expression of GPC3 protein and its significance in lung squamous cell carcinoma显示文摘 | Qiang Lin Li-wen Xiong Xu-feng Pan Jun-feng Gen Guo-liang Bao Hui-fang Sha Jiu-xian Feng Chun-yu Ji Ming Chen | 2012 | Medical Oncology2012，，2： | 1 |
| 9 | Design and optimal research of a non-contact adjustable magnetic adsorption mechanism for a wall-climbing welding robot显示文摘 | Wu Minghui Pan Gen Zhang Tao | 2013 | International Journal of Advanced Robotic Systems2013，10，1： | 1 |
| 10 | Lack of Association Between DNMT3B Polymorphisms and Sporadic Parkinson's Disease in a Han Chinese Population显示文摘Dear Editor,Recently, several single nucleotide polymorphisms (SNPs;rs34094401 on RAD51B, rs41309351 on CPXM1,rs143555311 on MPHOSPH10, rs141620200 on SERPINA1, and rs2424913 on DNMT3B) have been associated with Parkinson’s disease (PD) in Caucasians [1–3]. Considering the genetic variance among different | Hong Pan Jun-Yi Shen Juan-Juan Du Shi-Shuang Cui Jin Liu Yi-Qi Lin Yi-Xi He Yang Fu Chao Gao Gen Li Sheng-Di Chen Jian-Fang Ma | 2018 | Neuroscience Bulletin2018，34，5： | 1 |
| 11 | Cerebral glucose metabolic prediction from amnestic mild cognitive impairment to Alzheimer’s dementia:a meta-analysis显示文摘Brain 18F-fluorodeoxyglucose positron emission tomography(FDG-PET)has been utilized to monitor disease conversion from amnestic mild cognitive impairment(aMCI)to Alzheimer’s dementia(AD).However,the conversion patterns of FDG-PET metabolism across studies are not conclusive.We conducted a voxel-wise meta-analysis using Seed-based d Mapping that included 10 baseline voxel-wise FDG-PET comparisons between 93 aMCI converters and 129 aMCI nonconverters from nine longitudinal studies.The most robust and reliable metabolic alterations that predicted conversion from aMCI to AD were localized in the left posterior cingulate cortex(PCC)/precuneus.Furthermore,meta-regression analyses indicated that baseline mean age and severity of cognitive impairment,and follow-up duration were significant moderators for metabolic alterations in aMCI converters.Our study revealed hypometabolism in the left PCC/precuneus as an early feature in the development of AD.This finding has important implications in understanding the neural substrates for AD conversion and could serve as a potential imaging biomarker for early detection of AD as well as for tracking disease progression at the predementia stage. | Hai Rong Ma Li Qin Sheng Ping Lei Pan Gen Di Wang Rong Luo Hai Cun Shi Zhen Yu Dai Jian Guo Zhong | 2018 | Translational Neurodegeneration2018，7，1： | 1 |
| 12 | Active corrosion protection of phosphate loaded PEO/LDHs composite coatings:SIET study显示文摘This work produced a Mg Al-layered double hydroxide by hydrothermal treatment of a plasma electrolytic oxidation(PEO) coating on magnesium alloy AZ31 in an phosphate electrolyte, followed by an ion-exchange reaction in 0.1 M phosphate solution. The coated specimens were scratched. Characterization, including utilization of the localized technique SIET, measured the pH and p Mg distributions and optical morphologies around the artificial defects during immersion in 0.05 M NaCl solution. In contrast with phosphate loaded PEO/LDHs, a stronger alkalinization area(with pH 11.4~12.3) appeared in the passive PEO specimens. Due to formation of insoluble Mg(OH)_(2) products, the p Mg map showed depletion of Mg^(2+) in this high p H area. Combined with optical morphologies and SEM images, the better self-healing ability toward defects for phosphate loaded PEO/LDHs was confirmed. | Gen Zhang E Jiang Liang Wu Aitao Tang Andrej Atrens Fusheng Pan | 2022 | Journal of Magnesium and Alloys2022，10，5： | 1 |
| 13 | Long noncoding RNA Pvt1 promotes the proliferation and migration of Schwann cells by sponging microRNA-214 and targeting c-Jun following peripheral nerve injury显示文摘Research has shown that long-chain noncoding RNAs(lncRNAs) are involved in the regulation of a variety of biological processes, including peripheral nerve regeneration, in part by acting as competing endogenous RNAs. c-Jun plays a key role in the repair of peripheral nerve injury. However, the precise underlying mechanism of c-Jun remains unclear. In this study, we performed microarray and bioinformatics analysis of mouse crush-injured sciatic nerves and found that the lncRNA Pvt1 was overexpressed in Schwann cells after peripheral nerve injury. Mechanistic studies revealed that Pvt1 increased c-Jun expression through sponging miRNA-214. We overexpressed Pvt1 in Schwann cells cultured in vitro and found that the proliferation and migration of Schwann cells were enhanced, and overexpression of miRNA-214 counteracted the effects of Pvt1 overexpression on Schwann cell proliferation and migration. We conducted in vivo analyses and injected Schwann cells overexpressing Pvt1 into injured sciatic nerves of mice. Schwann cells overexpressing Pvt1 enhanced the regeneration of injured sciatic nerves following peripheral nerve injury and the locomotor function of mice was improved. Our findings reveal the role of lncRNAs in the repair of peripheral nerve injury and highlight lncRNA Pvt1 as a novel potential treatment target for peripheral nerve injury. | Bin Pan Di Guo Li Jing Ke Li Xin Li Gen Li Xiao Gao Zhi-Wen Li Wei Zhao Hu Feng Meng-Han Cao | 2023 | Neural Regeneration Research2023，18，5： | 1 |
| 14 | Prevalence of Coronary Artery Fistula in a Single Center of China显示文摘 | Yue-Ying Pan Gen Chen Bin Chen Han-Lin Mu Yi-Qi Cheng He-Song Zeng Han-Xiong Guan | 2018 | Chinese Medical Journal2018，，12： | 1 |
| 15 | DDG1 and G Protein α Subunit RGA1 Interaction Regulates Plant Height and Senescence in Rice(Oryza sativa)显示文摘Many studies have already shown that dwarfism and moderate delayed leaf senescence positively impact rice yield,but the underlying molecular mechanism of dwarfism and leaf senescence remains largely unknown.Here,using map-based cloning,we identified an allele of DEP2,DDG1,which controls plant height and leaf senescence in rice.The ddg1 mutant displayed dwarfism,short panicles,and delayed leaf senescence.Compared with the wild-type,ddg1 was insensitive to exogenous gibberellins(GA)and brassinolide(BR).DDG1 is expressed in various organs,especially in stems and panicles.Yeast two-hybrid assay,bimolecular fluorescent complementation and luciferase complementation image assay showed that DDG1 interacts with theα-subunit of the heterotrimeric G protein.Disruption of RGA1 resulted in dwarfism,short panicles,and darker-green leaves.Furthermore,we found that ddg1 and the RGA1 mutant was more sensitive to salt treatment,suggesting that DDG1 and RGA1 are involved in regulating salt stress response in rice.Our results show that DDG1/DEP2 regulates plant height and leaf senescence through interacting with RGA1. | Xi Liu Chuxuan Zhao Di Wang Gen Pan Xiaonan Ji Su Gao Tanxiao Du Yating Feng Wenjing Chen | 2023 | Phyton-International Journal of Experimental Botany2023，92，7： | 1 |
| 16 | Significant contribution of carbonyls to atmospheric oxidation capacity(AOC)during the winter haze pollution over North China Plain显示文摘Atmospheric carbonyl compounds play significant roles in the cycling of radicals and have exhibited surprisingly high levels in winter that were well correlated to particulate matter,for which the reason have not been clearly elucidated.Here we measured carbonyl compounds and other trace gasses together with PM_(2.5)over urban Jinan in North China Plain during the winter.Markedly higher carbonyl concentrations(average:14.63±4.21 ppbv)were found during wintertime haze pollution,about one to three-times relative to those on nonhaze days,with slight difference in chemical composition except formaldehyde(HCHO).HCHO(3.68 ppbv),acetone(3.17 ppbv),and acetaldehyde(CH_3CHO)(2.83 ppbv)were the three most abundant species,accounting for~75% of the total carbonylson both haze and non-haze days.Results from observational-based model(OBM)with atmospheric oxidation capacity(AOC)indicated that AOC significantly increased with the increasing carbonyls during the winter haze events.Carbonyl photolysis have supplied key oxidants such as RO_(2) and HO_(2),and thereby enhancing the formation of fine particles and secondary organic aerosols,elucidating the observed haze-carbonyls inter-correlation.Diurnal variation with carbonyls exhibiting peak values at early-noon and night highlighted the combined contribution of both secondary formation and primary diesel-fuel sources.1-butene was further confirmed to be the major precursor for HCHO.This study confirms the great contribution of carbonyls to AOC,and also suggests that reducing the emissions of carbonyls would be an effective way to mitigate haze pollution in urban area of the NCP region. | Xue Yang Gen Zhang Guang Pan Guolan Fan Houyong Zhang Xuan Ge Mingyue Du | 2024 | Journal of Environmental Sciences2024，，5： | 0 |
| 17 | Significant influence of self-possessed moisture of limonitic nickel laterite on sintering performance and its action mechanism显示文摘In consideration of the abundant moisture of limonitic nickel laterite mined,it is essential to determine whether the selfpossessed moisture of limonitic nickel laterite after pre-dried is appropriate for sintering.Thus,based on the characterization of limonitic nickel laterite,the influence of its self-possessed moisture on sintering performance was expounded by sinter pot tests and the relevant mechanism was revealed by the systematical analyses of the granulation properties of sinter mixture,thermodynamic conditions during sintering and mineralogy of product sinter.The results indicate that the selfpossessed moisture of limonitic nickel laterite indeed has significant infuence on its sintering performance.At the optimum self-possessed moisture of 21 mass%,sinter indices are relatively better with tumble index,productivity and solid fuel rate of 48.87%,1.04 t m^(-2) h^(-1)and 136.52 kg t^(-1),respectively,due to the superior granulation properties of sinter mixture and thermodynamic conditions during sintering,relatively large amount of silico-ferrite of calcium and alumina and tighter sinter microstructure.However,sintering performance of limonitic nickel laterite is still much poorer than that of ordinary iron ores.It is feasible to strengthen limonitic nickel laterite sintering by inhibiting the over-fast sintering speed and improving the thermodynamic conditions during sintering. | Yu-xiao Xue De-qing Zhu Jian Pan Zheng-qi Guo Hong-yu Tian Gen Li Qing-zhou Huang Liao-ting Pan Xue-zhong Huang | 2022 | Journal of Iron and Steel Research(International)2022，29，9： | 0 |
| 18 | Synthesis and antitumor activity of heterocyclic acid ester derivatives of 20S-camptothecins显示文摘新混合物被 acylation 方法综合了的 camptothecins 的一系列杂环的酸酉旨,他们的在里面 vitro 并且在 vivo 反肿瘤,活动被评估。细胞毒素的结果证明 6 在 CPT 的衍生物的六个班上在六根人的癌症房间线上拥有了最好的功效。在测试结果的 vivo 显示了那 9 最好对老鼠肝癌 H22 的反肿瘤活动比 topotecan。 | Di Zao Li Yan Li Xiao Guang Chen Chen Gen Zhu Jing Yang Hong Yan Liu Xian Dao Pan | 2007 | Chinese Chemical Letters2007，18，11： | 0 |
| 19 | Morphology,structure and corrosion resistance of Mg-Al LDH films fabricated in different Al^(3+)concentration solutions显示文摘In situ-grown Mg-Al layered double hydroxide(LDH)films were obtained on an anodized AZ31 substrate,with the immersion of sample in different concentrations of Al^(3+)solution.The structure,composition and morphology of LDH films were investigated by X-ray diffraction(XRD),Fourier transform infrared(FTIR)and scanning electronic microscopy(SEM),and the corrosion behavior of LDH films was further studied by electrochemical impedance spectroscopy(EIS).The influence of Al^(3+)concentration on the growth behavior of LDH was also discussed.The results indicated that the nest-like structure of MgAl-LDH film was composed of interconnected MgAl-LDH nanosheets.Besides,the LDH obtained in0.032 mol·L^(-1)Al^(3+)solution,possessing dense laminated structure,could effectively seal the porous surface of anodic oxide film.EIS results revealed that the samples coated with LDH films showed a higher electrochemical impedance,and thus,the corrosion resistance of samples coated with LDH films was signally improved compared with the anodized alloy. | Liang Wu Xing-Xing Ding Xiao-Feng Zhao Yuan-Huan Liu Xue-Long Hao Ai-Tao Tang Gen Zhang Fu-Sheng Pan | 2023 | Rare Metals2023，42，2： | 0 |
| 20 | Monitoring of CO_2 geological storage based on the passive surface waves显示文摘Carbon dioxide(CO2) capture and geological storage(CCS) is one of promising technologies for greenhouse gas effect mitigation. Many geotechnical challenges remain during carbon dioxide storage field practices, among which effectively detecting CO2 from deep underground is one of engineering problems. This paper reviews monitoring techniques currently used during CO2 injection and storage.A method developed based on measuring seismic microtremors is of main interest. This method was first successfully used to characterize a site in this paper. To explore its feasibility in CO2 storage monitoring,numerical simulations were conducted to investigate detectable changes in elastic wave signatures due to injection and geological storage of CO2. It is found that, although it is effective for shallow earth profile estimation, the surface wave velocity is not sensitive to the CO2 layer physical parameter variations,especially for a thin CO2 geological storage layer in a deep underground reservoir. | Dai Kaoshan Li Xiaofeng Song Xuehang Chen Gen Pan Yongdong Huang Zhenhua | 2014 | International Journal of Mining Science and Technology2014，24，5： | 0 |
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