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| 1 | Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant显示文摘AIM: To investigate if conversion to the mammalian target of rapamycin inhibitors(mTORi) improves renal function in diabetic and/or hypertensive liver transplant patients immunosuppressed with tacrolimus or cyclosporine.METHODS: The study included 86 liver graft recipients immunosuppressed with mTORi treatment after orthotopic liver transplantation(OLT), including all liver recipients with worsening renal function before conversion to mTORi(n = 55 patients) and recipients with normal renal function who converted to m TORi for other reasons(n = 31 patients). We identified patients with diabetes mellitus(n = 28), arterial hypertension(n = 27), proteinuria(n = 27) and all three factors(n = 8)(some patients have hypertension and diabetes and no proteinuria). The primary endpoint was evolution in renal function defined as the development in plasma creatinine as a function of diabetes mellitus(DM), hypertension(HT) or proteinuria. We required elevated serum creatinine for at least two weeks to define renal dysfunction.RESULTS: Only patients that converted because of renal failure with plasma creatinine levels > 1.5 mg/dL showed an improvement of renal function(2.14 to 1.77 mg/dL)(P = 0.02). Patients with DM showed no improvement of serum creatinine levels(1.31 mg/dL to 1.37 mg/dL) compared with non DM patients(1.31 mg/dL to 1.15 mg/dL)(P = 0.01), HT patients(1.48 mg/dL to 1.5 mg/dL) with non HT patients(1.21mg/d L to 1.08 mg/dL) and patients with proteinuria(1.44 mg/dL to 1.41 mg/dL) and no proteinuria(1.31 mg/dL to 1.11 mg/dL). CONCLUSION: In OLT recipients with diabetes or hypertensive nephropathy, conversion to m TORi does not improve renal function but stabilizes plasma levels of creatinine. Proteinuria is not a contraindication to conversion to m TORi; it also stabilizes renal function. Conversion to m TORi should only be avoided in patients with diabetes, hypertension and proteinuria. | José M álamo Claudia Olivares Lydia Barrera Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Jordi Muntané Francisco J Padillo Miguel A Gómez | 2015 | World Journal of Transplantation2015，5，1： | 6 |
| 2 | Laparoscopic approach in gastrointestinal emergencies显示文摘This review focuses on the laparoscopic approach to gastrointestinal emergencies and its more recent indications. Laparoscopic surgery has a specific place in elective procedures, but that does not apply in emergency situations. In specific emergencies, there is a huge range of indications and different techniques to apply, and not all of them are equally settle. We consider that the most controversial points in minimally invasive procedures are indications in emergency situations due to technical difficulties. Some pathologies, such as oesophageal emergencies, obstruction due to colon cancer, abdominal hernias or incarcerated postsurgical hernias, are nearly always resolved by conventional surgery, that is, an open approach due to limited intraabdominal cavity space or due to the vulnerability of the bowel. These technical problems have been solved in many diseases, such as for perforated peptic ulcer or acute appendectomy for which a laparoscopic approach has become a wellknown and globally supported procedure. On the other hand, endoscopic procedures have acquired further indications, relegating surgical solutions to a second place; this happens in cholangitis or pancreatic abscess drainage. This endoluminal approach avoids the need for laparoscopic development in these diseases. Nevertheless, new instruments and new technologies could extend the laparoscopic approach to a broader array of potentials procedures. There remains, however, a long way to go. | Rosa M Jimenez Rodriguez Juan José Segura-Sampedro Mercedes Flores-Cortés Francisco López-Bernal Cristobalina Martín Verónica Pino Diaz Felipe Pareja Ciuro Javier Padillo Ruiz | 2016 | World Journal of Gastroenterology2016，22，9： | 5 |
| 3 | Conservative management of perforated duodenal diverticulum: A case report and review of the literature显示文摘Duodenal diverticula are a relatively common condition. They are asymptomatic, unless they become complicated, with perforation being the rarest but most severe complication. Surgical treatment is the most frequently performed approach. We report the case of a patient with a perforated duodenal diverticulum, which was diagnosed early and treated conservatively with antibiotics and percutaneous drainage of secondary retroperitoneal abscesses. We suggest this method could be an acceptable option for the management of similar cases, provided that the patient is in good general condition and without septic signs. | David Martínez-Cecilia Alvaro Arjona Sánchez Manuel Gómez álvarez Eva Torres Tordera Antonio Luque Molina Victor Valentí Azcárate Javier Briceo Delgado Francisco Javier Padillo Pedro López-Cillero Sebastián Rufián Pea | 2008 | World Journal of Gastroenterology2008，14，12： | 2 |
| 4 | Translational pancreatic cancer research:a comparative study on patient-derived xenograft models显示文摘AIM To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude mice.METHODS This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were obtained surgically from patients with a pathological diagnosis of pancreatic adenocarcinoma. Tumour samples from pancreatic cancer patients were transplanted into nude mice in three different locations(intraperitoneal, subcutaneous and pancreatic). Histological analysis(haematoxylin-eosin and Masson's trichrome staining) and immunohistochemical assessment of apoptosis(TUNEL), proliferation(Ki-67), angiogenesis(CD31) and fibrogenesis(α-SMA) were performed. When a tumour xenograft reached the target size, it was reimplanted in a new nude mouse. Three sequential tumour xenograft generations were generated(F1, F2 and F3).RESULTS The overall tumour engraftment rate was 61.1%. The subcutaneous model was most effective in terms of tissue growth(69.9%), followed by intraperitoneal(57.6%) and pancreatic(55%) models. Tumour development was faster in the subcutaneous model(17.7 ± 2.6 wk) compared with the pancreatic(23.1 ± 2.3 wk) and intraperitoneal(25.0 ± 2.7 wk) models(P = 0.064). There was a progressive increase in the tumour engraftment rate over successive generations for all three models(F1 28.1% vs F2 71.4% vs F3 80.9%, P < 0.001). There were no significant differences in tumour xenograft differentiation and cell proliferation between human samples and the three experimental models among the sequential generations of tumour xenografts. However, a progressive decrease in fibrosis, fibrogenesis, tumour vascularisation and apoptosis was observed in the three experimental models compared with the human samples. All three pancreatic patient-derived xenograft models presented similar histological and immunohistochemical characteristics.CONCLUSION In our experience, the faster development andgreatest number of viable xenografts could make the subcutaneous model the best option for experimentation in pancreatic cancer. | Mercedes Rubio-Manzanares Dorado Luis Miguel Marín Gómez Daniel Aparicio Sánchez Sheila Pereira Arenas Juan Manuel Praena-Fernández Juan Jose Borrero Martín Francisco Farfán López Miguel ángel Gómez Bravo Jordi Muntané Relat Javier Padillo Ruiz | 2018 | World Journal of Gastroenterology2018，24，7： | 2 |
| 5 | Alpha(2)-adrenoceptor agonists inhibit vitreal glutamate and aspartate accumulation and preserve retinal function after transient ischemia显示文摘 | Donello JE Padillo EU Webster ML | 2000 | J Pharmacol Exp Ther2000，296，1： | 2 |
| 6 | Learning curve for robotic-assisted laparoscopic rectal cancer surgery显示文摘 | Rosa M. Jiménez-Rodríguez José Manuel Díaz-Pavón Fernando Portilla de Juan Emilio Prendes-Sillero Hisnard Cadet Dussort Javier Padillo | 2013 | International Journal of Colorectal Disease2013，，6： | 2 |
| 7 | Influence of marginal donors on liver preservation injury 显示文摘 | Briceno J Marchal T Padillo J | 2002 | Transplantation2002，74，4： | 1 |
| 8 | Immunomodulatory activity of TNF-alpha during acute liver injury induced by D-galactosamine and its protection by PGE1 in rats 显示文摘 | Lozano JM Padillo J Montero JL | 2003 | Int I mmunopharmacol2003，3，2： | 1 |
| 9 | Human fibrinogen patches application reduces intraabdominal infectious complications in pancreas transplant with enteric drainage显示文摘 | Padillo J Arjona-Sanchez A Ruiz-Rabelo J | 2010 | World J Surg2010，34，： | 1 |
| 10 | Efect of bl I iary drainage Oil plasma levels of endotoxin, cytokines, and C - reative protein in obstructive jatmdice 显示文摘 | Padillo FJ Muntane J Montem JL | 2002 | World Surg2002，26，： | 1 |
| 11 | Multivariate analysis of factors associated with renal dysfunction in patients with ob- structive jaundice 显示文摘 | Padillo FJ Cruz A Bricefio J | 2015 | Br J Surg2015，92，： | 1 |
| 12 | BNP as marker of heart dysfunction in patients with liver cirrhosis 显示文摘 | Padillo J P Rioja | 2010 | Eur J Gastroenterol Hepatol2010，22，11： | 1 |
| 13 | Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin -induced diabetic rats显示文摘 | Kusari J Zhou S Padillo E | 2007 | Invest Ophthalmol Vis Sci2007，48，： | 1 |
| 14 | Influence of marginal donors on liver preservation injury显示文摘 | Briceno J Marchal T Padillo J | 2002 | Transplantation2002，74，4： | 1 |
| 15 | Melatonin prevents experimental liver cirrhosis induced by thioacetamide in rats 显示文摘 | Cruz A Padillo FJ Torres E | 2005 | Pineal Research2005，39，9： | 1 |
| 16 | Outcomes of Liver Transplantation in Candidates With Portal Vein Thrombosis显示文摘 | G. Suarez Artacho L. Barrera Pulido J.M. Alamo Martinez J. Serrano Diez-Canedo C. Bernal Bellido L.M. Marín Gomez J. Padillo Ruiz M.A. Gómez Bravo | 2010 | Transplantation Proceedings2010，，8： | 1 |
| 17 | Melatonin protects against renal oxidative stress after obstructive jaundice in rats显示文摘 | Adolfo Cruz Francisco J Padillo Isaac Túnez Carmen Mu?oz Jose Granados Carlos Pera-Madrazo Pedro Montilla | 2001 | European Journal of Pharmacology2001，，2： | 1 |
| 18 | Effect of internal biliary drainage on plasma levels of endotoxin, cytokines, and C-reactive protein in patients with obstructive jaundice显示文摘 | Padillo FJ Muntane J Montero JL | 2002 | World J Surg2002，26，11： | 1 |
| 19 | alpha(2)-Adrenoceptor agonists inhibit vitreal glutamate and aspartate accumulation and preserve retinal function after transient ischemia显示文摘 | Donello JE Padillo EU Webster ML | | 0，，01： | 1 |
| 20 | In- creased plasma levels of alrial natriuretic peptide and endocrine markers of volume depletion in patients with obstructive jaundice显示文摘 | GALLARDO J M PADILLO J MARTN-MALO A | 1998 | Br J Surg1998，85，1： | 1 |
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