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| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | Prognostically relevant gene signatures of high-grade serous ovarian carcinoma显示文摘 | Verhaak Roel G W Tamayo Pablo Yang Ji-Yeon Hubbard Diana Zhang Hailei Creighton Chad J Fereday Sian Lawrence Michael Carter Scott L Mermel Craig H Kostic Aleksandar D Etemadmoghadam Dariush Saksena Gordon Cibulskis Kristian Duraisamy Sekhar | 2013 | Journal of Clinical Investigation2013，，1： | 2 |
| 3 | No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics显示文摘 | Sanders Alan R Duan Jubao Levinson Douglas F Shi Jianxin He Deli Hou Cuiping Burrell Gregory J Rice John P Nertney Deborah A Olincy Ann Rozic Pablo Vinogradov Sophia Buccola Nancy G Mowry Bryan J Freedman Robert Amin Farooq Black Donald W | 2008 | The American Journal of Psychiatry2008，，4： | 1 |
| 4 | Control system for a PWM based STATCOM显示文摘 | Pablo G G Aurelio G C | 2000 | IEEE Trans on PWRD2000，15，4： | 1 |
| 5 | Patterns of fruit set within inflorescence of Ancratiurn maritpiurn ( Amaryllidaceae ) : nouniform pollination, resource limitation, or architectural effects 显示文摘 | Monica M Pablo G Javier G | 2000 | American Journal of Botany2000，87，： | 1 |
| 6 | Multifractal analysis of ground-level ozone concentrations at urban, suburban and rural background monitoring sites in Southwestern Iberian Peninsula显示文摘 | Pablo P D Francisco J J H Eduardo G de R | 2013 | Atmospheric Pollution Research2013，4，2： | 1 |
| 7 | Both melatonin and a putative nuclear melatonin receptor agonist CGP 52608 stimulate glutathione peroxidase and glutathione reductase activities in mouse brain in vivo显示文摘 | Pablos M I Guerrero J M Oritz G G | 1997 | Neuroendocrinol Lett1997，18，2： | 1 |
| 8 | Concurrent and simple digital controller of an AC/DC converter with power factor correction based on an FPGA显示文摘 | de ANGEL C PABLO Z OSCAR G | 2003 | IEEE Trans Power Electr2003，18，1： | 1 |
| 9 | Is the application of carbendazimharmful to healthy plants?Evidence of weak phytotoxicity in tobacco显示文摘 | Pablo C G Juan M R Rosa M R | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 10 | Improvement of the waste oil vacuum distillation recycling by continuous extraction with dense propane 显示文摘 | Jesusa R Pablo C Maria T G | 2007 | Industrial & Engineering Chemistry Research2007，46，1： | 1 |
| 11 | Synthesis of a novel ditopic ligand incorporating directly bonded 1,10-phenanthroline and 2,2 2:6 2″-terpyridine units显示文摘 | SERGIO T | 2006 | Tetrahedron Letters2006，47，： | 1 |
| 12 | Sunflower protein films incorporated with clove essential oil have potential application for the preservation of fish patties显示文摘 | Pablo R. Salgado M. Elvira López-Caballero M. Carmen Gómez-Guillén Adriana N. Mauri M. Pilar Montero | 2013 | Food Hydrocolloids2013，，1： | 1 |
| 13 | Regeneration of used lubricant oil by ethane extraction 显示文摘 | Jesusa R Pablo C Maria T G | 2007 | Journal of Supercritical Fluids2007，39，3： | 1 |
| 14 | Transformerless Inverter for Single-Phase Photovoltaic Systems显示文摘 | Roberto G Jesus L Pablo S | 2007 | IEEE Transactions on Power Electronics2007，22，2： | 1 |
| 15 | The utility of low-cost photogrammetry for stiffness analysis and finite-element validation of wood with knots in bending显示文摘 | Pablo G Juan O | 2013 | Biosystems engineering2013，114，： | 1 |
| 16 | Matagenes and molecular pattern discovery using matrix facterization显示文摘 | Jean-Philippe B Pablo T Todd R G | 2004 | Proc Nail Acad Sei USA2004，101，： | 1 |
| 17 | Genetic variability related to serum uric acid concentration and risk of Parkinson’s disease显示文摘 | Isabel González‐Aramburu Pascual Sánchez‐Juan Silvia Jesús Ana Gorostidi Eduardo Fernández‐Juan Fátima Carrillo María Sierra Pilar Gómez‐Garre María T. Cáceres‐Redondo José Berciano Javier Ruiz‐Martínez Onofre Combarros Pablo Mir Jon Infante | 2013 | Mov Disord2013，，： | 1 |
| 18 | Fault-generated mountain fronts in southeast Spain: Geomorphologic assessment of tectonic and seismic activity 显示文摘 | Silva Pablo G Goy J L Zazo C | 2003 | Geomorphology2003，50，13： | 1 |
| 19 | Symmetry groups, semidefinite pro grams and sums of squares显示文摘 | Karin G Pablo A P | 2004 | Journal of Pure and Ap plied Algebra2004，192，123： | 1 |
| 20 | Atmospheric pressure gas chromatography-time-of-flight-mass spectrometry(APGCTOF-MS)for the determination of regulated and emerging contaminants in aqueous samples after stir bar sorptive extraction(SBSE)显示文摘 | Marina G P-H Eduardo G-M Pablo A L-M | 2014 | Analytica chimica acta2014，851，： | 1 |
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