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| 1 | A Study on Solid/Melt Interfaces and the Formation of<100> Texture in Solidified FCC Metals显示文摘The (100) texture of solidified fcc metals, caused by the preferential (100) dendrite growth, could be closeIy related to solid/melt interfaces which behave differently along different crystallographic orientation. The stability and roughness of {111} and {100} solid/melt interfaces of fcc metals were investigated using a modified Temkin multi-layer model. It is demonstrated that {100}crystal/melt interface is more unstable and rougher than {111} interface. The effect of the stability of crystal/melt interface on the (100) texture formation in solidified fcc metals has been analysed and discussed. | D.Y.Li(Dept. of Mater. Sci & Eng., The Pennsylvania State University, University Park, PA 16802, USA )B.Debray and J.A.Szpunar(Dept. of Metall. Eng., McGill University, 3450 Uuiversity Street, Molitreal, PQ, Canada H3A 2A7) | 1997 | Journal of Materials Science & Technology1997，13，6： | 20 |
| 2 | 低剂量利福昔明可预防肝硬化失代偿期患者的并发症并提高生存率显示文摘利福昔明已被推荐作为肝性脑病(HE)和自发性细菌性腹膜炎(SBP)的预防药物。该研究旨在探讨低剂量利福昔明是否能预防肝硬化患者的整体并发症和延长生存期。在这项多中心随机开放标签的前瞻性研究中,200例失代偿期肝硬化患者按1∶1的比例随机分配。利福昔明组患者给予利福昔明400 mg,每日2次,疗程6个月,其余治疗策略在两组患者中尽量保持不变。主要疗效终点是总并发症发生率和无肝移植生存率。次要终点是各种主要肝硬化相关并发症的发生率,以及Child-Pugh评分和分级。 | ZENG X SHENG X WANG PQ 朱玉凡 牛俊奇 | 2021 | 临床肝胆病杂志2021，37，3： | 15 |
| 3 | Necessity and indications of invasive treatment for Budd-Chiari syndrome显示文摘BACKGROUND:The development of collaterals in Budd-Chiari syndrome has been described and these collaterals play an important role in the presentation of this disease.These collaterals are diagnostic and their use in management strategy has never been evaluated.This study aimed to investigate the indications,feasibility and necessity of invasive treatment for patients with Budd-Chiari syndrome and to determine whether such a strategy is necessary for optimal management.METHODS:Twenty-nine patients who had been treated at our unit were enrolled in this study.Based on physical and biochemical examination,and hemodynamic compensation by collaterals,18 patients underwent radiological intervention (group A),while the other 11 had no invasive treatment (group B).The related hemodynamic parameters were acquired when percutaneous angiography was performed.RESULTS:In group A,all patients underwent successfully inferior vena cava (IVC) balloon angioplasty with or without stenting.Four patients also underwent hepatic vein angioplasty.In these patients,the mean IVC pressure before and after treatment was statistically different (29.3±9.2 vs 15.1±4.6 mmHg,P<0.01).The mean IVC pressure was much lower in group B than in group A (12.9±2.4 vs 29.3±9.2 mmHg,P<0.01),but there was no difference from that of the patients after radiological treatment (12.9±2.4 vs 15.1±4.6 mmHg,P>0.05).Median follow-up was 32.3 months (mean 21.3 months;range 3-61 months).In the course of follow-up,the patients in group A survived with good systemic status except for re-stenosis in one patient who underwent re-canalization of the IVC.In group B,10 patients had good systemic status except one patient who had a meso-caval shunt because of deterioration.CONCLUSIONS:The rationale of 'early diagnosis and early treatment' is not suitable for all patients with Budd-Chiari syndrome.Satisfactory survival can be achieved in some patients without invasive treatment,who are completely compensated by rich collaterals.Nonetheless,a positive treatment procedure should be performed if the patient's situation worsens in the course of regular follow-up. | Department of General Surgery (Fu Y,Sun YL,Ma XX,Xu PQ,Feng LS,Tang Z and Luo CH),Institute of Hepatic Vascular Disease (Sun YL),Department of Radiological Intervention (Guan S and Wang ZW),First Affiliated Hospital,Zhengzhou University School of Medicine,Zhengzhou 450052,China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 10 |
| 4 | MicroRNA: A matter of life or death显示文摘Progressive cell loss due to apoptosis is a pathological hallmark implicated in a wide spectrum of degenerative diseases such as heart disease, atherosclerotic arteries and hypertensive vessels, Alzheimer's disease and other neurodegenerative disorders. Tremendous efforts have been made to improve our understanding of the molecular mechanisms and signaling pathways involved in apoptosistic cell death. Once ignored completely or overlooked as cellular detritus, microRNAs (miRNAs) that were discovered only a decade ago, have recently taken many by surprise. The importance of miRNAs has steadily gained appreciation and miRNA biology has exploded into a massive swell of interest with enormous range and potential in almost every biological discipline because of their widespread expression and diverse functions in both animals and humans. It has been established that miRNAs are critical regulators of apoptosis of various cell types. These small molecules act by repressing the expression of either the proapoptotic or antiapoptotic genes to produce antiapoptotic or proapoptotic effects. Appealing evidence has been accumulating for the involvement of miRNAs in human diseases associated with apoptotic cell death and the potential of miRNAs as novel therapeutic targets for the treatment of the diseases. This editorial aims to convey this message and to boost up the research interest by providing a timely, comprehensive overview on regulation of apoptosis bymiRNAs and a synopsis on the pathophysiologic implications of this novel regulatory network based on the currently available data in the literature. It begins with a brief introduction to apoptosis and miRNAs, followed by the description of the fundamental aspects of miRNA biogenesis and action, and the role of miRNAs in regulating apoptosis of cancer cells and cardiovascular cells. Speculations on the development of miRNAs as potential therapeutic targets are also presented. Remarks are also provided to point out the unanswered questions and to outline the new directions for the future research of the field. | Zhiguo Wang, Research Center, Montreal Heart Institute and Department of Medicine, University of Montreal, Montreal, PQ H1T 1C8, Canada | 2010 | World Journal of Biological Chemistry2010，1，4： | 6 |
| 5 | The experimental study of genetic engineering human neural stem cells mediated by lentivirus to express multigene显示文摘 | Cai PQ Tang X Lin YQ Martin O Sun GY Xu L Yang YK Zhou TH | 2006 | 中国生物学文摘2006，20，5： | 6 |
| 6 | Tuberculosis versus lymphomas in the abdominal lymph nodes: evaluation with contrast-enhancedCT显示文摘 | Yang ZG Min PQ Sone S etal | 1999 | AJRAmJ Roentgenol1999，172，3： | 1 |
| 7 | Rapid necrotic killing of poly-morphonuclear leukocytes is caused by quorum-sensing-controlled pro-duetion of rhamnolipid by Pseudomoms aemginosa 显示文摘 | Jensen PQ Bjamsholt T Phipps R | 2007 | Microbiology2007，5153，5： | 1 |
| 8 | Tuberculosis versus lymphomas in the abdominal lymph nodes;evaluation with contrast-enhanced CT显示文摘 | Yang ZG Min PQ Sone S | 1999 | AJR1999，172，3： | 1 |
| 9 | A quantitative morpho- metric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease 显示文摘 | Davies CA Mann DM Sumpter PQ | 1987 | J Neural Sci1987，78，2： | 1 |
| 10 | Instrumented posterior lumbar interbody fusion in adult spondylolisthesis显示文摘 | Yu CH Wang CT Chen PQ | | 0，，12： | 1 |
| 11 | Simultaneous detection of respir- atory virus by a multiplex reverse transcription polymerase chain re- action combined with flow -through reverse dot blotting assay 显示文摘 | Li PQ Yang ZF Chen JX | 2008 | Diagn Microbiol Infect Dis2008，62，1： | 1 |
| 12 | The postural stability control and gait pattern of idiopathic scoliosis adolescents显示文摘 | Chen PQ Wang JL Tsuang YH | 1998 | Clin Biomech(Bristol Avon)1998，13，： | 1 |
| 13 | Ectopic posterior pituitary lobe and perivertricular heterotopia: cerebral malformation with the same underlying mechanism? 显示文摘 | Mitchell LA Thamas PQ Zacharim MR | 2002 | AJNR2002，23，9： | 1 |
| 14 | rhBMP-2 release from injectable poly(DL-lactic-co-glycolic acid)/calcium-phosphate cement composites显示文摘 | Ruhe PQ Hedberg EL Padron NT | | 0，，3： | 1 |
| 15 | rhBMP-2 release from injectable poly(DL-lactic-co-glycolic acid)/calcium- phosphate cement composites 显示文摘 | Ruhe PQ Hedberg EL Padron NT | 2003 | J Bone Joint Surg Am2003，85，3： | 1 |
| 16 | A systematic review and metaanalysis of clinical outcomes of vitrectomy with or without intravitreal bevacizumab pretreatment for severe diabetic retinopathy 显示文摘 | Zhao LQ Zhu H Zhao PQ | 2011 | Br J Ophthalmol2011，95，9： | 1 |
| 17 | Interbody fusion cage design using intergrated global layout and local microstructure topology optimization 显示文摘 | Lin CY Hsiao CC Chen PQ | 2004 | Spine2004，29，16： | 1 |
| 18 | Phase Ⅱ study of gemcitabine and erlotinib as adjuvant therapy for patients with resected pancreatic cancer显示文摘 | Bao PQ Ramanathan RK Krasinkas A | 2011 | Ann Surg Oncol2011，18，4： | 1 |
| 19 | Instrumented posterior lumbar interbody fusion in adult spondylolisthesis 显示文摘 | Yu CH Wang CT Chen PQ | 2008 | Clin Orthop Relat Res2008，466，12： | 1 |
| 20 | Oil casing steel LF refining process T[O]and inclusion control (in Chinese)显示文摘 | Yao TL Lin P Tong PQ | | 0，，02： | 1 |
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