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	题名	作者	年代	出处	被引量
1	Uptake of albumin nanoparticle surface modified with glycyrrhizin by primary cultured rat hepatocytes显示文摘AIM: To investigate the uptake difference between bovine serum albumin nanoparticle (BSA-NP) and bovine serum albumin nanoparticles with their surface modified byglycyrrhizin (BSA-NP-GL) and to develop a novel hepatocyte targeting BSA-NP-GL based on active targeting technology mediated by specific binding site of GL on rat cellular membrane. METHODS: Calcein loaded bovine serum albumin nanoparticles (Cal-BSA-NP) were prepared by desolvation process. Glycyrrhizin was conjugated to the surface reactive amino groups (SRAG) of Cal-BSA-NP by sodium periodate oxidization, which resulted in calcein-loaded bovine serum albumin nanoparticles with their surface modified by glycyrrhizin (Cal-BSA-NP-GL). The morphology of the two types of prepared nanoparticles (NP) was observed by transmission electron microscopy. The diameter of NP was measured with a laser particle size analyzer. The interaction between Cal-BSA-NP-GL and primary cultured hepatocytes was studied through cellular uptake experiments. The uptake amount of Cal-BSA-NPGL and Cal-BSA-NP by rat hepatocytes was determinedby fluorospectrophotometry. Uptake characteristics were investigated through experiments of competitive inhibition of specific binding site of GL. RESULTS: Both Cal-BSA-NP-GL and Cal-BSA-NP had regular spherical surfaces. The average diameter of CalBSA-NP-GL and Cal-BSA-NP was 77 and 79 nm respectively. The uptake amount of the two NP by hepatocytes reached its maximum at 2 h after incubation. The uptake amount of Cal-BSA-NP-GL by rat hepatocytes was 4.43-fold higher than that of Cal-BSA-NP. There was a significant difference in the uptake of Cal-BSA-NP-GL and Cal-BSA-NP by hepatocytes (P<0.01). The uptake of Cal-BSA-NP-GL was inhibited when GL was added previously to isolated rat hepatocytes, and the uptake of Cal-BSA-NP was not affected by GL.CONCLUSION: A binding site of GL is present on the surface of rat hepatocytes, BSA-NP-GL may be internalized via this site by hepatocytes and can be used as a drug carrier for active targeting of delivery drugs to hepatocytes.	Sheng-JunMao Shi-XiangHou RuHe Liang-KeZhang Da-PengWei Yue-QiBi HuiJin	2005	World Journal of Gastroenterology2005，11，20：	7
2	A Flexible Method for Effort Estimation by Analogy显示文摘	Li J Ruhe G Al-Emran A	2006	Empirical Software Engineering2006，12，1：	1
3	Methicillin-susceptible Staphylococcus aureus nasal colonization and the risk of subsequent methicillin-resistant Staphylococcus aureus infections among hospitalized patients显示文摘	Ruhe JJ de Guzman L Moss M	2011	Diagn Microbiol Infect Dis2011，71，2：	1
4	rhBMP-2 release from injectable poly(DL-lactic-co-glycolic acid)/calcium-phosphate cement composites显示文摘	Ruhe PQ Hedberg EL Padron NT		0，，3：	1
5	rhBMP-2 release from injectable poly(DL-lactic-co-glycolic acid)/calcium- phosphate cement composites 显示文摘	Ruhe PQ Hedberg EL Padron NT	2003	J Bone Joint Surg Am2003，85，3：	1
6	Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta--analysis of monoamine depletion studies显示文摘	Ruhe HG Mason NS Schene AH	2007	Mol Psychiatry2007，12，4：	1
7	Polyelec-trolyte brushes显示文摘	RUHE J BALLAUFF M BIESALSKI M	2004	Adv Polym Sci2004，165，：	1
8	A power analysis for future clinical trials on the potential adverse effects of SSRIs on amygdala reactivity显示文摘有抗抑郁剂的青少年的处理可以在这张人口为 suicidality 导致增加的风险。杏仁之类的活动在与功能的磁性的回声成像(fMRI ) 感情的脸处理期间是感情的 dysregulation 的一项著名措施。与 fluoxetine ( NTR3103 )在我们的过早地结束的使随机化的临床的试用的数据之上基于在焦急并且或我们计算了的沮丧的女孩( 12-14 岁) r =与发现效果缩放 0.66 与安慰剂相比,仅仅 8 个题目被需要活动追随者 16 星期处理与 fluoxetine 表明增加的杏仁之类。	M. A. Bottelier A. Schrantee G. van Wingen H. G. Ruhe M. B. de Ruiter L. Reneman	2016	Frontiers in Biology2016，11，3：	1
9	rhBMP-2 release from injectable poly (DL-lactic-co-glycolic acid)/calcium-phosphate cement composites显示文摘	Hedberg EL Padron NT	2003	J Bone Joint Surg Am2003，85，3：	1
10	Contact line shape on ultrahydrophobic post surfaces 显示文摘	Dorrer C Ruhe J	2007	Langmuir2007，23，6：	1
11	Contact Line Shape on Ultrahydrophobic PostSuffaces显示文摘	Dorrer C Ruhe J	2007	Langmuir2007，23，6：	1
12	Polyphenols prevent cell shedding from mouse mammary cancer spheroids and inhibit cancer cell invasion in confrontation cultures derived from embryonic stem cells显示文摘	Günther S Ruhe C Derikito M G	2007	Cancer Lett2007，250，1：	1
13	Hybrid Intelligence in Software Release Planning显示文摘	Ruhe G Ngo-The A	2004	International Journal on Hybrid Intelligent Systems2004，，1：	1
14	Hybrid Intelligence in Software Release Planning显示文摘	Günther Ruhe An Ngo The	2004	International Journal of Hybrid Intelligent Systems2004，，1：	1
15	Software release planning for evolving systems显示文摘	Omolade Saliu Guenther Ruhe	2005	Innovations Syst Softw Eng2005，1，：	1
16	Bone inductive properties of rhBMP - 2 loaded porous calcium phosphate cement implants in cranial defects in rabbits 显示文摘	RUHE P Q KROESE DEUTMAN H C WOLKE J G	2004	Biomaterials2004，25，11：	1
17	Software Release Planning: An Evolutionary and Iterative Approach显示文摘	Greer D Ruhe G	2004	Information and Software Technology2004，46，4：	1
18	Genetic alterations in the tyro-sine kinase transcriptome of human cancer cell lines显示文摘	Ruhe JE Streit S Hart S	2007	CancerRes2007，67，11：	1
19	Perflourinated polymer monolayers on porous silica for materials with super liquid repellent properties显示文摘	JUNG D H PARK I J CHOI Y K LEE S B PARK H S RUHE J	2002	Langmuir2002，18，：	1
20	Diazosolfonate polymer complexes: structure and wettability 显示文摘	BIESALSKIM RUHE J	1999	Macromoleeules1999，32，：	1

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