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| 1 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 2 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 3 | Propranolol for the prevention of postoperative arrhythmias in general thoracic surgery显示文摘 | Charles D Bayliff David R Massel Richard I Inculet Richard A Malthaner Susan D Quinton Frank S Powell Renee S Kennedy | 1999 | The Annals of Thoracic Surgery1999，，1： | 2 |
| 4 | Introduction of gaseous hydrides into an inductively coupled plasma mass spectrometer显示文摘 | POWELL M J BOOMER D W MCVICARS R J | 1986 | Analytical Chemistry1986，58，13： | 1 |
| 5 | Granulomtous enterocolitis induced in rat by purified bacterial cell wall fragmentals显示文摘 | CROMARTIE W J POWELL D W | 1985 | Gastroenterology1985，89，： | 1 |
| 6 | Modern tidal rhythmites deposited in a deep-water estuaty显示文摘 | Cowan E A Cai J Powell R D | 1998 | Geo-marine Letters1998，18，： | 1 |
| 7 | A low-cost GPS/inertial attitude heading reference system (AHRS) for general aviation applications显示文摘 | Gebre-Egziabher D Hayward R C Powell J D | 1998 | IEEE Position Location and Navigation Symposium1998，，： | 1 |
| 8 | Structure of a secoisolariciresinol diester from Salvia plebeia seed显示文摘 | POWELL R G PLATTNER R D | | 0，，12： | 1 |
| 9 | LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporterl (SGLT1)- mediated absorption of intestinal glucose 显示文摘 | Powell D R Smith M Greer J | 2013 | J Pharmacol Exp Ther2013，345，2： | 1 |
| 10 | Improved classification of conservation tillage adoption using high temporal and synthetic satellite imagery显示文摘 | Watts J D Powell S L Lawrence R L | 2011 | Remote Sensing of Environment2011，115，1： | 1 |
| 11 | Fast evaluation ofpolyharmonic splines in three dimensions显示文摘 | Beatson R K Powell M J D Tan A M | 2006 | IMA Jour-nal of Numerical Analysis2006，27，3： | 1 |
| 12 | Take it to the limit: Innovative CVaR applications to extreme credit risk measurement 显示文摘 | ALLEN D E POWELL R J | 2016 | European Journal of Operational Research2016，249，2： | 1 |
| 13 | Design of Multi- Sensor Attitude Determination Systems 显示文摘 | Gebre Egziabher D HayWard R C Powell J D | 2004 | IEEE Transactions on Aerospace and Electronic System2004，40，2： | 1 |
| 14 | Orthopyroxene-sillimanite-quartz assemblages:distribution,petrology,quantitative p-T-X constraints and p-T paths显示文摘 | Kelsey D E White R W Powell R | 2003 | J Metamorphic Geol2003，21，： | 1 |
| 15 | Design of multi-sensor attitude determination systems 显示文摘 | GEBRE-EGZIABHER D HAYWARD R C POWELL J D | 2004 | IEEE Transactions on Aerospace and Electronic Systems2004，40，2： | 1 |
| 16 | A comparisonof commercial enzymes for the aqueous enzymatic extraction ofcom oil from com germ显示文摘 | Moreau R A Johnston D B Powell M J^ | 2004 | J Am Oil Chem Soc2004，81，11： | 1 |
| 17 | A secoisolariciresinol branched fatty diester from Salvia plebeia seed显示文摘 | PLATTNER R D POWELL R G | | 0，，01： | 1 |
| 18 | Effect of LX4211 on glucose homeostasis and body composition in preclinical models 显示文摘 | Powell D R DaCosta C M Smith M | 2014 | J Pharmacol Exp Ther2014，350，2： | 1 |
| 19 | Regulation and function of insulin-like growth factor-binding protein-1显示文摘 | Lee P D Conover C A Powell D R | 1993 | Proc Soc Exp Biol Med1993，204，： | 1 |
| 20 | Assessing Personality in the Employment Interview:the Impact of Training on Rater Accuracy 显示文摘 | Powell D M Goffin R D | 2009 | Human Performance2009，，22： | 1 |
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