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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Surgical outcome and long-term follow up after laparoscopic rectosigmoid resection in women with deep infiltrating endometriosis 显示文摘 | Seracchioli R Poggioli G Pierangeli F | 2007 | B JOG2007，114，7： | 1 |
| 3 | Behavioral and development al outcomes of prenatal and postnatal vanadium exposure in the rat显示文摘 | Poggioli R Arlerri R Bertolini A | 2001 | Pharmacological Res2001，43，： | 1 |
| 4 | Anti-mullerian hormone as a seminal marker for spermatogenesis in non-obstructive azoospermia 显示文摘 | Fenichel P Rey R Poggioli S | 1999 | Hum Reprod1999，14，： | 1 |
| 5 | Behavioral and develop- mental outcomes of prenatal and postnatal vanadium exposure in the rat显示文摘 | Poggioli R Arlerri R Bertolini A | 2001 | Pharmacological Research2001，43，4： | 1 |
| 6 | ACTH-(1-24) and alpha-MSH antagonize feeding behavior stimulated by kappa opiate agonists 显示文摘 | Poggioli R Vergoni A V Bertolini A | 1986 | Peptides1986，7，5： | 1 |
| 7 | Surgical outcome and long-term follow up after laparoscopic rectosigmoid resection in women with deep infiltrating endometriosis 显示文摘 | Seracchioli R Poggioli G Pierangeli F | 2007 | BJOG2007，114，7： | 1 |
| 8 | Behavioral and developmental outcomes of prenatal and postnatal vanadium exposure in the rat 显示文摘 | Poggioli R Arletti R Bertolini A | 2001 | Pharmaeol Res2001，43，4： | 1 |
| 9 | ACTH-(1-24) and alpha-MSH antagonize feeding behavior stimulated by kappa opiate agonists显示文摘 | Vergoni A V Bertolini A | 1986 | Peptides1986，7，5： | 1 |
| 10 | Effect of potassium channel modulators on male sexual behavior显示文摘 | Benelli A Arletti R Poggioli R | 1997 | Life Sci1997，60，45： | 1 |
| 11 | Auti-Mullerian hormone as a sencinal marker for spermatogenesis in nenohstruetive azoospermia 显示文摘 | Fenichel P Rey R Poggioli S | 1999 | Hum Reprod1999，14，8： | 1 |
| 12 | Quality of Life After Islet Transplantation 显示文摘 | Poggioli R Faradji RN Ponte G | 2006 | Am J Transplant2006，6，2： | 1 |
| 13 | Antitussive effect of K+ channel openers显示文摘 | Benelli A Arletti R | 1999 | European Journal of Pharmacology1999，371，： | 1 |
| 14 | Antitussive effect of K+ channel openers显示文摘 | Poggioli R Benelli A Arletti R Cavazzuti E Bertolini A | 1999 | Eur J Pharmacol1999，371，： | 1 |
| 15 | Behavioral and develop- mental outcomes of prenatal and postnatal vanadium exposure in the rat显示文摘 | Poggioli R Arlerri R Bertolini A | 2001 | Pharmacological Research2001，43，4： | 1 |
| 16 | Anti - Mfillerian hor- mone as a seminal marker for spermatogenesis in non - ob- structive azoospermia显示文摘 | F6nichel P Rey R Poggioli S | 1999 | Hum Reprod1999，14，8： | 1 |
| 17 | Epicardial adipose tissue has a unique transcriptome modified in severe coronary artery disease显示文摘 | MCANINCH E A FONSECA T L POGGIOLI R | 2015 | Obesity(Silver Spring Md)2015，33，： | 1 |
| 18 | ACTH-(1-24) and alpha-MSH antagonize feeding Be havior stimulated by kappa opiate agonists 显示文摘 | POGGIOLI R VERGONI A V BERTOLINI A | 1986 | Pep- tides1986，7，5： | 1 |
| 19 | Islet xenotransplantation显示文摘 | Poggioli R Inverardi L Ricordi C | 2002 | Cell Transplant2002，11，2： | 1 |
| 20 | Surgical outcome and long- term follow up after laparoscopic reetosigmoid resection in women with deep infiltrating endometriosis 显示文摘 | Seracehioli R Poggioli G Pierangeli F | 2007 | B JOG2007，114，7： | 1 |
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