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| 1 | Early phase of acute pancreatitis: Assessment and management显示文摘Acute pancreatitis(AP) is a potentially life-threatening disease with a wide spectrum of severity. The overall mortality of AP is approximately 5%. According to the revised Atlanta classification system, AP can be classified as mild, moderate, or severe. Severe AP often takes a clinical course with two phases, an early and a late phase, which should both be considered separately. In this review article, we first discuss general aspects of AP, including incidence, pathophysiology, etiology, and grading of severity, then focus on the assessment of patients with suspected AP, including diagnosis and risk stratification, followed by the management of AP during the early phase, with special emphasis on fluid therapy, pain management, nutrition, and antibiotic prophylaxis. | Veit Phillip Jrg M Steiner Hana Algül | 2014 | World Journal of Gastrointestinal Pathophysiology2014,5,3: | 19 |
| 2 | The evolution and functional diversification of animal microRNA genes显示文摘microRNAs (miRNAs ) 是 22 核苷酸(nt ) 的一个丰富的班在更高真核细胞的染色体是弥漫的规章的 RNA。以便充分在染色体理解他们的突起,阐明是必要的能多样化 miRNA 活动的分子的机制。在这评论,我们描述一些允许新奇 miRNA 功能出现的许多策略,与 miRNA 基因怎么在动物演变的特别强调。这些机制在他们的顺序包括变化,处理,或表示模式;miRNA 的获得 * 功能或 antisense 处理;并且 de novo 基因出生。miRNAs 的设备和通用性位于下面多半演变并且变化他们怎么成为了更高的染色体的主导的成分。 | Na Liu Katsutomo Okamura David M Tyler Michael D Phillips Wei-Jen Chung Eric C Lai | 2008 | Cell Research2008,18,10: | 17 |
| 3 | Relationship between the exocrine and endocrine pancreas after acute pancreatitis显示文摘AIM:To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.METHODS:Relevant literature cited in three major biomedical journal databases(EMBASE,MEDLINE,and Scopus)was reviewed independently by two authors.There were no language constraints but the search was limited to human studies.Studies included were cohort studies of adult patients who were discharged after an attack of acute pancreatitis.Patients were excluded if they were under 18 years of age or had a previous diagnosis of prediabetes or diabetes mellitus,pancreatic exocrine insufficiency,or chronic pancreatitis.The main outcome measure was the prevalence of concomitant pancreatic exocrine insufficiency in patients who were diagnosed with prediabetes and diabetes mellitus after an attack of acute pancreatitis.Subgroup analysis was conducted for patients who were diagnosed with prediabetes only and those who were diagnosed withdiabetes mellitus only.Subgroup analysis looking at the time course of concomitant pancreatic exocrine and endocrine insufficiency was also conducted.Pooled prevalence and corresponding 95%confidence intervals were calculated for all outcome measures and P-values<0.05 were deemed statistically significant.RESULTS:Eight clinical studies comprising of 234patients met all eligibility criteria.The pooled prevalence of newly diagnosed prediabetes or diabetes in individuals after acute pancreatitis was 43%(95%CI:30%-56%).The pooled prevalence of pancreatic exocrine insufficiency in individuals after acute pancreatitis was 29%(95%CI:19%-39%).The prevalence of concomitant pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes was 40%(95%CI:25%-55%).The prevalence of concomitant pancreatic exocrine insufficiency among individuals with prediabetes alone and diabetes mellitus alone was 41%(95%CI:12%-75%)and 39%(95%CI:28%-51%),respectively.Further analysis showed that the prevalence of concomitant pancreatic exocrine insufficiency in individuals with prediabetes or diabetes decreases over time after an attack of acute pancreatitis.CONCLUSION:Pancreatic exocrine insufficiency occurs in 40%of individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.Further studies are needed to investigate the pathogenesis of diabetes in this setting. | Stephanie L M Das James I C Kennedy Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov | 2014 | World Journal of Gastroenterology2014,20,45: | 9 |
| 4 | Hypothalamic-pituitary-adrenal axis function during perinatal depression显示文摘Abnormal function of the hypothalamic–pituitary–adrenal(HPA) axis is an important pathological finding in pregnant women exhibiting major depressive disorder. They show high levels of cortisol proinflammatory cytokines, hypothalamic-pituitary peptide hormones and catecholamines, along with low dehydroepiandrosterone levels in plasma. During pregnancy, the TH2 balance together with the immune system and placental factors play crucial roles in the development of the fetal allograft to full term. These factors, when altered, may generate a persistent dysfunction of the HPA axis that may lead to an overt transfer of cortisol and toxicity to the fetus at the expense of reduced activity of placental 11β-hydroxysteroid dehydrogenase type 2. Epigenetic modifications also may contribute to the dysregulation of the HPA axis. Affective disorders in pregnant women should be taken seriously, and therapies focused on preventing the deleterious effects of stressors should be implemented to promote the welfare of both mother and baby. | Phillipe Leff Gelman Mónica Flores-Ramos Margarita López-Martínez Carlos Cruz Fuentes Juan Pablo Reyes Grajeda | 2015 | Neuroscience Bulletin2015,31,3: | 6 |
| 5 | The importance of depression and alcohol use in coronary artery bypass graft surgery patients:risk factors for delirium and poorer quality of life显示文摘ObjectiveTo 调查消沉,焦虑和压力是否增加风险因为谵妄和在冠的动脉以后的生活(QOL ) 的差的质量绕过(CABG ) 180 个 CABG 病人的 surgery.MethodsA 总数(63.5 ± 的吝啬的年龄;10.1 年, 82.2% 男性) 完成了基线和手术后的自我报告问询表估计悲痛和 QOL。事件谵妄与结构化的临床的会见手术后地被诊断,病人们在在 63 个人(35% 样品) 开发的 consciousness.ResultsDelirium 为混乱和骚乱 post-operatively 每天被监视。在为 covariates 的调整以后,谵妄显著地与消沉被联系[机会比率(或) :1.08;95% 信心间隔(CI ) :1.03-1.13, P = 0.003 ] ,焦虑(或:1.07;95% CI:1.02-1.13, P = 0.01 ) 并且应力(或:1.05;95% CI:1.00-1.09, P = 0.03 ) 。外科手术前的消沉分数与更差的 QOL 包括被联系身体疼痛(β=− 0.39, P = 0.013 ) ,活力(β=− 0.32, P = 0.020 ) ,社会工作(β=− 0.51, P ≤0.001 ) ,感情的角色功能(β=− 0.44, P = 0.003 ) 并且一般健康(β=− 0.33, P = 0.038 ) 。在 covariates 之中,白酒使用的有害层次一致地与更差的 QOL.ConclusionsDepression 被联系,而消沉,焦虑和压力与谵妄风险被联系,白酒使用的有害层次一致地与更差的 QOL 被联系。这些调查结果点将推进在经历冠的 revascularization 的冠的心疾病人口检验消沉和白酒使用的有害层次的研究。 | Joanne M Humphreys Linley A Denson Robert A Baker Phillip J Tully | 2016 | Journal of Geriatric Cardiology2016,13,1: | 5 |
| 6 | 酗酒对年轻人血压水平和其他心血管健康指标的影响:2011-2014年美国国家健康与营养调查结果显示文摘无节制地饮酒(酗酒)在年轻人中流行率最高,然而,酗酒对年龄18~45岁的个体血压和其他心血管健康指标的影响知之甚少。为了确定长期酗酒对血压、血脂和血糖水平的影响,并确定这些关联在男性和女性之间是否存在差异,Piano等分析了来自美国国家健康与营养调查(the US national health and nutrition examination survey)的数据. | 刘莉 叶鹏 Piano MR Burke L Kang M Phillips SA | 2018 | 中华高血压杂志2018,26,8: | 5 |
| 7 | Dairy food consumption and body weight and fatness studied longitudinally over the adolescent period显示文摘 | PHILLIPS S M BANDINI L G CYR H | 2003 | International Journal of Obesity2003,27,: | 2 |
| 8 | European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease显示文摘 | S. Husby S. Koletzko I.R. Korponay-Szabó M.L. Mearin A. Phillips R. Shamir R. Troncone K. Giersiepen D. Branski C. Catassi M. Lelgeman M. M?ki C. Ribes-Koninckx A. Ventura K.P. Zimmer | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012,,1: | 2 |
| 9 | Intralesioanl fluorouracil/epinephrine injectable gel for treatment of condylomata acuminata:a phase 3 clinical study显示文摘 | Swinehart JM Sperling M Phillips S | 1997 | Arch Dermatol1997,133,1: | 2 |
| 10 | Airbome laser hydrography in Australia 显示文摘 | PENNY M F ABBOT R H PHILLIPS D M | 1986 | App Opt1986,25,13: | 2 |
| 11 | Prostate-specific antigen (PSA) screening: has the pendulum swung too far?显示文摘 | Jason M Phillips E David Crawford | 2011 | Asian Journal of Andrology2011,13,5: | 2 |
| 12 | European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease显示文摘 | S. Husby S. Koletzko I.R. Korponay-Szabó M.L. Mearin A. Phillips R. Shamir R. Troncone K. Giersiepen D. Branski C. Catassi M. Lelgeman M. M?ki C. Ribes-Koninckx A. Ventura K.P. Zimmer | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012,,1: | 2 |
| 13 | Hepatitis delta virus显示文摘 | Sarah A Hughes Heiner Wedemeyer Phillip M Harrison | 2011 | The Lancet2011,,9785: | 2 |
| 14 | Modelling pom pom type models with high-order finite volume schemes显示文摘 | ABOUBACAR M AGUAYO J P PHILLIPS P M | 2005 | Journal of Non-Newtonian Fluid Mechanics2005,126,23: | 1 |
| 15 | Early radiographic and clinical results of balloon kyphoplasty for the treatmene of osteoporotic vertebral compression fractures显示文摘 | Phillips FM Ho E Campbell Hupp M | 2003 | Spine2003,28,19: | 1 |
| 16 | Modeling of Species Distributions With MaxEnt: New Extensions anti a Comprehensive Evaluation 显示文摘 | PHILLIPS S J DUDIK M | 2008 | Ecography2008,31,2: | 1 |
| 17 | In vitro antibacterial effects of antilipopolysaccharide DNA aptamer-C1 qrs complexes 显示文摘 | Bruno J G Carrillo M P Phillips T | 2008 | Folia Microbiol(Praha)2008,53,4: | 1 |
| 18 | A new aluminum hydroxide octamer (SO4)5 · 16H2O显示文摘 | Casey W H Olmstead M M Phillips B L | 2005 | Inorg Chem2005,44,: | 1 |
| 19 | Refinement of diagnostic assays for a probable causal mutation for porcine and human malignant hyperthermia显示文摘 | Otsu K Phillips M S Khanna V K | 1992 | Genomics1992,13,: | 1 |
| 20 | Effect of oxygen on breath markers of oxidative sires显示文摘 | Phillips M Cataneo RN Greenberg J | 2003 | Eur Respir J2003,21,1: | 1 |