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| 1 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 2 | China organ donation and transplantation update: the Hangzhou Resolution显示文摘The much-anticipated change in the practice of organ donation and transplantation in China is now underway and affirmed by an important Hangzhou Resolution promulgated at the 2013 China Transplant Congress.Support of the National Health and Family Planning Commission On October 29,2013,in a meeting of the National Health and Family Planning Commission (NHFPC)officials with Jie-Fu Huang,Head of National Organ Transplant Committee(OTC), Hai-Bo Wang,Director of China Organ Transplant Response System (COTRS) | Jie-Fu Huang Shu-Sen Zheng Yong-Feng Liu Hai-Bo Wang Jeremy Chapman Philip O'Connell Michael Millis John Fung Francis Delmonico | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，2： | 6 |
| 3 | LSTM RNN:detecting exploit kits using redirection chain sequences显示文摘While consumers use the web to perform routine activities,they are under the constant threat of attack from malicious websites.Even when visiting‘trusted’sites,there is always a risk that site is compromised,and,hosting a malicious script.In this scenario,the injected script would typically force the victim’s browser to undergo a series of redirects before reaching an attacker-controlled domain,which,delivers the actual malware.Although these malicious redirection chains aim to frustrate detection and analysis efforts,they could be used to help identify web-based attacks.Building upon previous work,this paper presents the first known application of a Long Short-Term Memory(LSTM)network to detect Exploit Kit(EK)traffic,utilising the structure of HTTP redirects.Samples are processed as sequences,where each timestep represents a redirect and contains a unique combination of 48 features.The experiment is conducted using a ground-truth dataset of 1279 EK and 5910 benign redirection chains.Hyper-parameters are tuned via K-fold cross-validation(5f-CV),with the optimal configuration achieving an F1 score of 0.9878 against the unseen test set.Furthermore,we compare the results of isolated feature categories to assess their importance. | Jonah Burgess Philip O’Kane Sakir Sezer Domhnall Carlin | 2021 | Cybersecurity2021，4，1： | 4 |
| 4 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 5 | 延长萎凋时间引起的无性系红茶化学成分的变化显示文摘用物理萎凋程度相同但萎凋时间不同的鲜叶制成的红茶的化学成分不同,咖啡碱含量随萎凋时间的延长而逐步增加,而茶黄素含量则因萎凋时间的延长而减少,尽管第Ⅰ组和第Ⅱ组挥发性芳香化合物(VFC)总量随着萎凋时间的延长而减小,但芳香指数(Ⅱ组VFC/Ⅰ组VFC)却因萎凋时间的延长而增大。茶红素水平没有因萎凋时间的变化而产生显著的变化,但茶师的评价以萎凋14小时最好。此后,随着萎凋时间的延长,茶师的评价降低。 | Philip o owuor 莫治雄 | 1991 | 广东茶业1991，0，2： | 3 |
| 6 | Heart Disease and Stroke Statistics—2006 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Thomas Thom Nancy Haase Wayne Rosamond Virginia J. Howard John Rumsfeld Teri Manolio Zhi-Jie Zheng Katherine Flegal Christopher O’Donnell Steven Kittner Donald Lloyd-Jones David C. Goff Yuling Hong Robert Adams Gary Friday Karen Furie Philip Gorelick Bret | 2006 | Circulation2006，，6： | 3 |
| 7 | Phytochemical analysis,hepatoprotective and antioxidant activity of Alchornea cordifolia methanol leaf extract on carbon tetrachloride-induced hepatic damage in rats显示文摘Objective:To investigate the hepatoprotective and antioxidant activities of Alchornea cordifolia (A.cordifolia) leaf extract.Methods:Various solvent fractions of the methanol extract of the leaf of the plant.4.cordifolia Mull.Arg(Fam:Euphorbiaceae) were evaluated for hepatoprotective activity by carbon tetrachloride-induced liver damage in rats.The degree of protection was measured by using biochemical parameters such as serum glutamate oxalate transaminase(SGOT/ AST),serum glutamate pyruvate transaminase(SCPT/ALT),alkaline phosphatase(ALP) and total bilirubin.The in vitro antioxidant activity of the extract was also evaluated by the I,I-diphenyl 2-picrylhydrazyl(DPPH) free radical scavenging assay.The extract was subjected to preliminary phytoehemical screening.Results:The ethyl acetate and chloroform fractions,at a dose of 300 mg/kg,produced significant(P<0.05) hepatoprolection by decreasing the activities of the serum enzymes and bilirubin while there were marked scavenging of the DPPH free radicals by the fractions.The effects were comparable to those of the standard drugs used for the respective experiments,silymarin and ascorbic acid.Alkaloids,flavonoids,saponins and tannins were delected in the phylochemical screening.Conclusion:From this study,it was concluded that the plant of A.cordifolia possesses hepatoprotective as well as antioxidant activities and these activities reside mainly in the ethyl acetate and acetone fractions of methanol leaf extract. | Patience O Osadebe Festus BC Okoye Philip F Uzor Nneka R Nnamani Ijeoma E Adiele Nkemakonam C Obiano | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 2 |
| 8 | The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase显示文摘 | Thomas F Franke Sung-Il Yang Tung O Chan Ketaki Datta Andrius Kazlauskas Deborah K Morrison David R Kaplan Philip N Tsichlis | 1995 | Cell1995，，5： | 2 |
| 9 | Developmet of an amperometric L-ascorbic acid (Vitamin C)sensor based on electropolymerised aniline for pharmaceutical and food analysis显示文摘 | Philip J O' Connell Cicile Gormally Miloslav Pravda | 2001 | Analytica Chimica Acta2001，431，： | 2 |
| 10 | Impact of Premorbid Undernutrition on Outcome in Stroke Patients显示文摘 | James P. Davis Andrew A. Wong Philip J. Schluter Robert D. Henderson John D. O’Sullivan Stephen J. Read | 2004 | Stroke: Journal of the American Heart Association2004，，8： | 2 |
| 11 | Gastric acid control with esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole: a five-way crossover study显示文摘 | Philip Miner Philip O Katz Yusong Chen Mark Sostek | 2003 | The American Journal of Gastroenterology2003，，12： | 2 |
| 12 | Radiation and convection-driven transient heat transfer during sublimation growth of silicon carbide single crystals 显示文摘 | KLEIN O PHILIP P SPREKELS J | 2001 | Journal of Crystal Growth2001，222，4： | 1 |
| 13 | The oxidation of aldehydes to acids with calcium hypochlorite 显示文摘 | Stephen O N Philip M K | 1982 | Tetra- hedron Letters1982，23，31： | 1 |
| 14 | Local Heat Transfer and Pressure Drop for Finned-Tube Heat Exchangers Using Oval Tubes and Vortex Generatots 显示文摘 | O'Brien James E Sohal Manohar S Wallstedt Philip C | 2004 | Journal of Heat Transfer2004，126，82： | 1 |
| 15 | Changes in carbon balance of tropical forests:Evidence from long-term plots显示文摘 | Philips O L Halhi Y Higuchi N | | 0，，5388： | 1 |
| 16 | Adsorption,sequestration,and bioaccessibility of As(V)in soils显示文摘 | JAE K Y MARK O B PHILIP M J | 2002 | EnvironSci Technol2002，36，21： | 1 |
| 17 | A preliminary assessment of consumer's exposure to organochlorine pesticides in fruits and vegetables and the potential health risk in Acera Metropolis,Ghana显示文摘 | CRENTSIL K B AUGUSTINE D PHILIP O Y | 2011 | Food Chemistry2011，128，4： | 1 |
| 18 | Relation of Increased Prebeta-1 High-Density Lipoprotein Levels to Risk of Coronary Heart Disease显示文摘 | Lin T. Guey Clive R. Pullinger Brian Y. Ishida Patricia M. O’Connor Christian Zellner Omar L. Francone Jason M. Laramie Josefina M. Naya-Vigne Ketevan A. Siradze Prakash Deedwania Rita F. Redberg Philip H. Frost Albert B. Seymour John P. Kane Mary J. Mall | 2011 | The American Journal of Cardiology2011，，3： | 1 |
| 19 | Cereal harvesting-A mathematical model显示文摘 | Philips P R O'Callaghan J R | 1974 | Journal of Agricultural Engineering Research1974，19，4： | 1 |
| 20 | Intraoperative ad- herence to a low tidal volume ventilation strategy in critically ill patients with preexisting acute lung injury显示文摘 | Chaiwat O Vavilala MS Philip S | 2011 | J Crit Care2011，26，2： | 1 |
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