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| 1 | The PPARγ-FGF1 axis: an unexpected mediator of adipose tissue homeostasis显示文摘 | Kai Sun Philipp E Scherer | 2012 | Cell Research2012，22，10： | 7 |
| 2 | Augmented reality assisted surgery: a urologic training tool显示文摘扩充现实广泛地在航空学被使用并且是在外科以内的一个发展中的概念。在这个预研项目,我们在古格尔·格拉斯 ® 上为使用开发了一个应用程序训练在怎么放可膨胀的阴茎修复术的泌尿学居民的光装头的显示。我们使用扩充的短语现实帮助了外科在外科的设置描述扩充现实的这个新奇应用程序。应用程序表明可膨胀的阴茎修复术放置的外科的过程的步。它也包含允许的软件用一个照相机的点从光装头的显示喂使教师能在阴茎修复术的放置期间与居民一起交往的兴趣的察觉。自愿参加学习的泌尿学受训练者和教师被给时间经历技术在起作用或 perioperative 背景并且要求完成反馈调查。从用 10 点规模的 30 个全部的参加者,教育实用性被评估 8.6,航行的容易被评估 7.6,到使用的可能性的被评估 7.4,并且在操作空间的分心被评估 4.9。当在受训练者和教师之间成层时,受训练者发现技术更教育有用,并且少些分散。总的来说, 81% 参加者在他们的住处程序想要这种技术,并且 93% 以后在操作房间里看见这种技术。这种技术的进一步的开发在完整的版本前被保证,并且进一步的研究是必要的更好描绘扩充现实的有效性在泌尿科的外科的训练的帮助外科。 | Ryan M Dickey Neel Srikishen Larry I Lipshultz Philippe E Spiess Rafael E Carrion Tariq S Hakky | 2016 | Asian Journal of Andrology2016，18，5： | 6 |
| 3 | 鸡后根神经节多巴胺细胞在体及体外培养中的免疫细胞化学观察显示文摘应用免疫细胞化学PAP法,研究了鸡胚和雏鸡后根神经节细胞内多巴胺递质的表现与胚胎发育过程中的变化,并在细胞培养条件下研究了周围靶组织——皮肤对后根节细胞胚胎发育的影响。鸡后根节细胞内多巴胺的免疫反应最先出现于E_(10),只占后根节细胞的0.8%,E_(18)时达5.6%,出壳后雏鸡为8.6%。在鸡后根节内,多巴胺免疫反应阳性细胞主要为较大的A类细胞,和极少较小的B类细胞。免疫反应阳性的周围神经末梢位于皮肤和交感干内。当取自E_9的鸡胚后根节细胞经7天培养后,部分神经细胞出现多巴胺免疫反应阳性;而取自E_6的鸡胚后根节细胞虽经10天培养后仍为免疫反应阴性;然而,将取自E_6后根节细胞与皮肤组织联合培养10天后,少量神经细胞及轴突出现多巴胺免疫阳性反应。作者认为:鸡后根节多巴胺细胞在胚胎时期的发育有赖于周围靶组织的作用。 | 周长满 Philippe E Audet G Geffard M Gaulin F | 1992 | 神经解剖学杂志1992，8，2： | 4 |
| 4 | Gelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain显示文摘AIM: To establish a novel, sensitive and high-throughput gelatinolytic assay to define new inhibitors and compare domain deletion mutants of gelatinase B/matrix metalloproteinase (MMP)-9. METHODS: Fluorogenic Dye-quenched (DQ)TM-gelatin was used as a substrate and biochemical parameters (substrate and enzyme concentrations, DMSO solvent concentrations) were optimized to establish a highthroughput assay system. Various small-sized libraries (ChemDiv, InterBioScreen and ChemBridge) of hetero-cyclic, drug-like substances were tested and compared with prototypic inhibitors. RESULTS: First, we designed a test system with gelatin as a natural substrate. Second, the assay was validated by selecting a novel pyrimidine-2,4,6-trione (barbitu- rate) inhibitor. Third, and in line with present structural data on collagenolysis, it was found that deletion of the O-glycosylated region significantly decreased gelatinolytic activity (kcat/kM ± 40% less than full-length MMP-9). CONCLUSION: The DQTM-gelatin assay is useful in high-throughput drug screening and exosite targeting. We demonstrate that flexibility between the catalytic and hemopexin domain is functionally critical for gelatinolysis. | Jennifer Vandooren Nathalie Geurts Erik Martens Philippe E Van den Steen Steven De Jonghe Piet Herdewijn Ghislain Opdenakker | 2011 | World Journal of Biological Chemistry2011，2，1： | 3 |
| 5 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 6 | Controlled syn-thesis of poly(ε-caprolactone)-grafted dextran copolymers as poten-tial environmentally friendly surfactants显示文摘 | Sabelle Ydens Delphine Rutot Philippe Deg e | 2000 | Macromolecules2000，33，： | 2 |
| 7 | Adipose tissue remodeling and obesity显示文摘 | Sun Kai Kusminski Christine M Scherer Philipp E | 2011 | Journal of Clinical Investigation2011，，6： | 2 |
| 8 | The functional complex network approach to foster forest resilience to global changes显示文摘Human impacts on Earth's ecosystems have greatly intensified in the last decades. This is reflected in unexpected disturbance events, as well as new and increasing socio-economic demands, all of which are affecting the resilience of forest ecosystems worldwide and the provision of important ecosystem services. This Anthropocene era is forcing us to reconsider past and current forest management and silvicultural practices, and search for new ones that are more flexible and better at dealing with the increasing uncertainty brought about by these accelerating and cumulative global changes. Here, we briefly review the focus and limitations of past and current forest management and silvicultural practices mainly as developed in Europe and North America. We then discuss some recent promising concepts, such as managing forests as complex adaptive systems, and approaches based on resilience, functional diversity, assisted migration and multi-species plantations, to propose a novel approach to integrate the functionality of species-traits into a functional complex network approach as a flexible and multi-scale way to manage forests for the Anthropocene. This approach takes into consideration the high level of uncertainty associated with future environmental and societal changes. It relies on the quantification and dynamic monitoring of functional diversity and complex network indices to manage forests as a functional complex network. Using this novel approach, the most efficient forest management and silvicultural practices can be determined, as well as where, at what scale, and at what intensity landscape-scale resistance, resilience and adaptive capacity of forests to global changes can be improved. | Christian Messier Jürgen Bauhus Frederik Doyon Fanny Maure Rita Sousa-Silva Philippe Nolet Marco Mina Núria Aquilué Marie-Josée Fortin Klaus Puettmann | 2019 | Forest Ecosystems2019，6，3： | 2 |
| 9 | Excluding infection through procalcitonin testing improves outcomes of congestive heart failure patients presenting with acute respiratory symptoms: Results from the randomized ProHOSP trial显示文摘 | Philipp Schuetz Alexander Kutz Eva Grolimund Sebastian Haubitz Désirée Demann Alaadin V?geli Fabienne Hitz Mirjam Christ-Crain Robert Thomann Claudine Falconnier Claus Hoess Christoph Henzen Robert J. Marlowe Werner Zimmerli Beat Mueller | 2014 | International Journal of Cardiology2014，，3： | 2 |
| 10 | Nacylhomoserine lactones undergo lactonolysis in a pH-,temperature-,and acyl chain length-dependent manner during growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa显示文摘 | YATES E A PHILIPP B BUCKLEY C | 2002 | Infect Immun2002，70，： | 1 |
| 11 | Aortic pulse pressure and extent of coronary artery disease in percutaneous transluminat coronary angioplasty candidate 显示文摘 | Philippe F Chematy E Blacher J | 2002 | Am J Hypertens2002，15，8： | 1 |
| 12 | Aortic pulse pressure and extent of coronary artery disease in percutaneous transluminal coronary angioplasty candidates显示文摘 | Philippe F Chemaly E Blacher J | 2002 | Am J Hypertens2002，15，： | 1 |
| 13 | Phylogeny of dermatophytes and dimorphilic fungi based on large subunit ribosomal RNA sequence comparisons显示文摘 | Leclerc MC Philippe H Gueho E | 1994 | J Med Vet Mycol1994，32，： | 1 |
| 14 | Assay for tyrosine hydroxylase in hypothalamic homoge- nates using high - performance liquid chromatography with electro- chemical detection 显示文摘 | Philipp E | 1987 | Journal of Chromatography1987，419，419： | 1 |
| 15 | Selective blockage of in-termediate-Conductance Ca2+-Activated K+Channel sup-presses proliferation of microvascular and macrovascular en-dothelial cells and angiogenesis in vitro显示文摘 | Ivica G Ines E Philipp H | 2005 | ArteriosclerosisThromb Vasc Biol2005，25，： | 1 |
| 16 | In silieo predictions of the temperature-dependent viscosities and electrical conductivities of functionalized and nonfunctionalized ionic liquids 显示文摘 | PHILIPP E SAFAK B TOBIAS K | 2011 | J Phys Chem B2011，115，： | 1 |
| 17 | Interindividual reproducibility in perioperative rotational alignment of femoral components in knee prosthesis surgery using the transepicondylar axis显示文摘 | Jerosch J Peuker E Philipps B | 2002 | Knee Surg Sports Traumatol Arthrosc2002，10，： | 1 |
| 18 | Apyramid approach to subpixel registration based on intensity 显示文摘 | Philippe Th' evenaz Urs E Ruttimann Michael Unser | 1998 | IEEE Transactions on Image Processing1998，7，1： | 1 |
| 19 | Metabolism of sinigrin(2-P ropenyl glucosinolate) by the human colonic microflora in a dynamic in vitro large Intestinal mode 显示文摘 | Cyrille Krul Christe l e Humblot Catherine Philippe | 2002 | Carcinogenesis2002，23，6： | 1 |
| 20 | Assessment of ethanol consumption and water drinking by NPY Y2 receptor knockout mice 显示文摘 | Todd ET Philippe N Patrik E | 2004 | Peptide2004，25，： | 1 |
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