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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | An EOQ model for items with Weibull distribution deterioration 显示文摘 | Covert R P Philip G C | 1973 | AIIE Transac- tions1973，5，4： | 1 |
| 3 | A- nalysis of behavior-related adverse experiences in clini- cal trials of montelukast显示文摘 | PHILIP G HUSTAD C M MALICE M P | 2009 | J Allergy Clin Immunol2009，124，： | 1 |
| 4 | The Writing Assignments and Writing Problems of Doctoral Students:Faculty Perceptions, Pedagogical Issues,and Needed Research显示文摘 | Christine P C Philip H | 1992 | English for Specific Purposes1992，，11： | 1 |
| 5 | Human Bcl-2 protects against AMPA receptor-mediated apoptosis 显示文摘 | Nam S C Philip M B Catherine J P | 2000 | Neurochem2000，74，4： | 1 |
| 6 | Asymptotics for linear processes显示文摘 | Philips P C B Solo V | 1992 | Ann Statist1992，20，： | 1 |
| 7 | A statistical-topographic model for mapping climatological precipitation over mountainous terrain 显示文摘 | Daly C Neilson R P Philips D L | 1994 | Journal of Applied Meteorology1994，33，： | 1 |
| 8 | An introduction toevaluating biometric systems显示文摘 | Philips P J martin A Wilson C L | | Computer0，32，2： | 1 |
| 9 | Staging of carcinoid tumours with 18 F-DOPA PET: a prospective, diagnostic accuracy study显示文摘 | Klaas P Koopmans Elisabeth GE de Vries Ido P Kema Philip H Elsinga Oliver C Neels Wim J Sluiter Anouk NA van der Horst-Schrivers Pieter L Jager | 2006 | Lancet Oncology2006，，9： | 1 |
| 10 | Adaptive cooling of integrated circuits using digital microfluidics 显示文摘 | Philip Y P Vamsee K P Krishnendu C | 2008 | IEEE Transactions on Very Large Scale Integration Systems2008，16，4： | 1 |
| 11 | Nucleotide sequence of the 5′-terminus of Newcastle disease virus and assembly of the complete genomic sequence: agreement with the “rule of six”显示文摘 | Philips R J Samson A C R Emmerson P T | 1998 | Arch Virol1998，143，： | 1 |
| 12 | Time Series Regression with a Unit Root显示文摘 | Philips P C B | 1987 | Economitrica1987，，3： | 1 |
| 13 | Ectopic pregnancy and medical abortion显示文摘 | Shannon C Brothers P Philip N | 2004 | Obstel Cynecol2004，104，1： | 1 |
| 14 | Ectopic pregnancy and medical abortion显示文摘 | Shannon C Brothers P Philip N | 2004 | Obstet Gynecol2004，104，： | 1 |
| 15 | Phase Ⅱ study of erlotinib in patients with advanced biliary cancer 显示文摘 | Philip P A Mahoney M R Allmer C | 2006 | J Clin Oncol2006，24，19： | 1 |
| 16 | Characterisation of pea cytosolic glutathione reductase expressed in transgenic tobacco显示文摘 | Rebecca G S Gary P C Philip M M | 2000 | Planta2000，211，： | 1 |
| 17 | An EOQ model for items with weibull distribution deterioration 显示文摘 | COVERT R P PHILIP G C | 1973 | liE Transactions1973，5，： | 1 |
| 18 | Investigating the levels and trends of organochlorine pesticides and polychlorinated biphenyl in sewage sludge显示文摘 | Bradley O C Nichola A P Philip J M | 2010 | Environment International2010，36，4： | 1 |
| 19 | A new synthesis of peracetic acid显示文摘 | Philips B Frostick F C Starcher P S | 1957 | J Am Chem Soc1957，79，22： | 1 |
| 20 | An EOQ model for items with Weibull distribution deterioration显示文摘 | Covert R P Philip G C | 1973 | IIE Transactions1973，5，2： | 1 |
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