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| 1 | Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy显示文摘AIM:To investigate whether tumor marker staining can improve the sensitivity of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)to diagnose pancreatic malignancy. METHODS:Patients who underwent EUS-FNA were retrospectively identified.Each EUS-FNA specimen was evaluated by routine cytology and stained for tumor markers p53,Ki-67,carcinoembryonic antigen(CEA) and CA19-9.Sensitivity,specificity,positive and negative predictive values(PPV and NPV),and positive and negative likelihood ratios(PLR and NLR)were calculated in order to evaluate the performance of each test to detect malignancy. RESULTS:Sixty-one specimens had complete sets of stains,yielding 49 and 12 specimens from pancreatic adenocarcinomas and benign pancreatic lesions due to pancreatitis,respectively.Cytology alone had sensitivity and specificity of 41%and 100%to detect malignancy, respectively.In 46%of the specimens,routine cytology alone was deemed indeterminate.The addition of either p53 or Ki-67 increased the sensitivity to 51%and 53%,respectively,with perfect specificity,PPV and PLR (100%,100%and infinite).Both stains in combination increased the sensitivity to 57%.While additional staining with CEA and CA19-9 further increased the sensitivity to 86%,the specificity,PPV and PLR were significantly reduced(at minimum 42%,84%and 1,respectively).Markers in all combinations performed poorly as a negative test(NPV 26%to 47%,and NLR 0.27 and 0.70).CONCLUSION:Immunohistochemical staining for p53 and Ki-67 can improve the sensitivity of EUS-FNA to diagnose pancreatic adenocarcinoma. | Alexander W Jahng Sonya Reicher David Chung Donna Varela Rahul Chhablani Anil Dev Binh Pham Jose Nieto Rose J Venegas Samuel W French Bruce E Stabile Viktor E Eysselein | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 3 |
| 2 | 残余应力导致三层聚烯烃管道防腐层剥离与开裂显示文摘这是美国运输部发起的研究项目,一个管道防腐层专家团队参与了本研究项目,评价了三层聚烯烃管道外防腐涂层(3LPO)的完整性。研究表明,三层聚烯烃管道外防腐涂层(3LPO)存在剥离和面层开裂两大完整性问题。过去几年里,据文献报道,三层聚烯烃管道外防腐涂层(3LPO)的熔结环氧粉末(FBE)底漆与钢管界面上发生多起防腐层剥离事故,以及聚丙烯(PP)面层发生开裂事故。这些防腐层事故引起人们对使用三层聚烯烃管道外防腐涂层(3LPO)的关注。一般来讲,三层聚烯烃管道外防腐涂层(3LPO)采用比较厚的聚烯烃面层增强防腐层抗机械损伤和防止水渗透的能力。但是,聚烯烃的热膨胀系数比钢材高得多,结果在防腐层系统里产生比较高的残余热应力。因为残余应力高,造成防腐层剥离,尤其在管端截短防腐层和任何防腐层的边上,因为这些是高应力集中部位。特别是假如钢管表面预处理不当,就无法保证防腐层持久达到很强的粘合强度。如果熔结环氧粉末(FBE)底漆配方选择不当,发生热氧化降解,也导致防腐层过早失效。如果使用温度很高,聚丙烯也会因为热氧化降解而变脆。在残余应力下,这样脆性的聚丙烯面层就会开裂。本文分析了三层聚烯烃管道外防腐涂层(3LPO)中的残余应力,并且探讨了残余应力对三层聚烯烃管道外防腐涂层(3LPO)剥离和聚丙烯(PP)面层开裂机理的影响。 | B.T.A.Cheng S Hung-jue J Han D Wong A Kehr M Mallozzi F Aguirre H Pham W Snider 王向农(译) | 2011 | 防腐保温技术2011，19，3： | 3 |
| 3 | Invivo imaging of siRNA delivery and silencing in tumors显示文摘 | MEDAROVA Z PHAM W FARRAR C | 2007 | Nat Med2007，13，3： | 1 |
| 4 | Relationships between sensory descriptors, consumer acceptability and volatile flavor compounds of American dry-cured ham显示文摘 | PHAM A J SCHILLING M W MIKEL W B | 2008 | Meat Science2008，80，3： | 1 |
| 5 | Anthropogenic influence on surface water quality of the Nhue and Day sub-river systems in Vietnam显示文摘 | Pham T M H Sthiannopkao S Kim K W | 2010 | Environmental Geochemistry and Health2010，32，3： | 1 |
| 6 | Biological denitrification in microbial fuel cells 显示文摘 | Clauwaert P Rabaey K Aelterman P Schamphelaire LD Pham TH Boeckx P Boon N Verstraete W | 2007 | Environ Sci Teehnol2007，41，9： | 1 |
| 7 | Effect of dietary lysine supplement on the performance of Mong Cai sows and their piglets显示文摘 | PHAM K T LE DUC N HENDRIKS W H | 2010 | Journal of Animal Science2010，23，3： | 1 |
| 8 | Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon I9 and 21 mutations treated with gefitinib or er显示文摘 | Riely G J Pao W Pham D | 2006 | Clin Cancer Res2006，12，： | 1 |
| 9 | Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib显示文摘 | Riely GJ Pao W Pham DK | | 0，，02： | 1 |
| 10 | Glucocorticoid-induced bone loss in mice can be reversed by the actions of parathyroid hormone and risedronate on different pathways for bone formation and miner- alization 显示文摘 | Yao W Cheng Z Pham A | 2008 | Arthritis Rheum2008，58，11： | 1 |
| 11 | Reliability modeling of multi-state degraded systems with multi-competing failures and random shocks显示文摘 | Li W J Pham H | 2005 | IEEE Transactions on Reliability2005，54，2： | 1 |
| 12 | Semi Fragile Watermark with Self Authentication and Self Recovery 显示文摘 | Seng W C Du J Pham B | 2009 | Malaysian Journal of Computer Science(S0127-9084)2009，22，1： | 1 |
| 13 | Mixed hematopoietic chimerism induces donor - specific tolerance for lung allografts in rodents显示文摘 | Pham SM Mitruka SN Youm W | 1999 | Am JRespirCrit CareMed1999，159，： | 1 |
| 14 | Phenolic acid composition of sprouted wheats by ultra-performance liquid chromatography (UPLC) and their antioxidant activities 显示文摘 | Pham V H Hatcher D W Barker W | 2011 | Food Chemistry2011，126，18： | 1 |
| 15 | Fibril formation by pH and temperature responsivesilk-elastin block copolymers 显示文摘 | Golinska M D Pham T T H Werten M W T etal | 2013 | Biomacromolecules 92013，14，： | 1 |
| 16 | Distinct Roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA Silencing Pathways显示文摘 | Lee Y S Nakahara K Pham J W | 2004 | Cell2004，117，1： | 1 |
| 17 | Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib 显示文摘 | Riely GJ Pao W Pham D | 2006 | Clin Cancer Res2006，12，3： | 1 |
| 18 | The role of graphene oxide content on the adsorp- tion-enhanced photocatalysis of titanium dioxide/gra- phene oxide composites显示文摘 | NGUYEN-PHAN T D PHAM V H SHIN E W | 2011 | Chem Eng J2011，170，1： | 1 |
| 19 | Promoted calcium-phosphate precipitation from solution on titanium for improved biocompatibil ityby ion implantation显示文摘 | Maitz MF Pham MT Matz W | 2002 | Surf Coat Technol2002，1581，： | 1 |
| 20 | Vapor-injected scroll co- mpressors显示文摘 | Beeton W L Pham H M | 2003 | ASHRAE Journal2003，45，4： | 1 |
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