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| 1 | Recent trends in liver transplantation for alcoholic liver disease in the United States显示文摘AIM To examine temporal changes in the indications for liver transplantation(LT) and characteristics of patients transplanted for alcoholic liver disease(ALD).METHODS We performed a retrospective cohort analysis of trends in the indication for LT using the United Network for Organ Sharing(UNOS) database between 2002 and 2015. Patients were grouped by etiology of the liver disease and characteristics were compared using χ~2 and t-tests. Time series analysis was used identifying any year with a significant change in the number of transplants per year for ALD, and before and after eras were modeled using a general linear model. Subgroup analysis of recipients with ALD was performed by age group, gender, UNOS region and etiology(alcoholic cirrhosis, alcoholic hepatitis and hepatitis C-alcoholic cirrhosis dual listing).RESULTS Of 74216 liver transplant recipients, ALD(n = 9400, 12.7%) was the third leading indication for transplant after hepatitis C and hepatocellular carcinoma. Transplants for ALD, increased from 12.8%(553) in 2002 to 16.5%(1020) in 2015. Time series analysis indicated a significant increase in the number of transplants per year for ALD in 2013(P = 0.03). There were a stable number of transplants per year between 2002 and 2012(linear coefficient 3, 95%CI:-4.6, 11.2) an increase of 177 per year between 2013 and 2015(95%CI: 119, 234). This increase was significant for all age groups except those 71-83 years old, was observed for both genders, and was incompletely explained by a decrease in transplants for hepatitis C and ALD dual listing. All UNOS regions except region 9 saw an increase in the mean number of transplants per year when comparing eras, and this increase was significant in regions 2, 3, 4, 5, 6, 8, 10 and 11.CONCLUSION There has been a dramatic increase in the number of transplants for ALD starting in 2013. | Catherine E Kling James D Perkins Robert L Carithers Dennis M Donovan Lena Sibulesky | 2017 | World Journal of Hepatology2017，9，36： | 6 |
| 2 | Genome-level analysis of genetic regulation of liver gene expression networks显示文摘 | Gatti, D Maki, A Chesler, EJ Kirova, R Kosyk, O Lu, L Williams, RW Perkins, A Langston, MA Threadgill, DW Rusyn, I | 2007 | 中国生物学文摘2007，21，11： | 3 |
| 3 | D-MELD risk capping improves post-transplant and overall mortality under markov microsimulation显示文摘AIM: To hypothesize that the product of calculated Model for End-Stage Liver Disease score excluding exception points and donor age(D-MELD) risk capping ± Rule 14 could improve post liver transplant and overall survival after listing.METHODS: Probabilities derived from the United Network for Organ Sharing database between 2002 and 2004 were used to simulate potential outcomes for all patients listed for transplantation. The Markov simula-tion was then modified by screening matches using a 1200 or 1600 D-MELD risk cap ± allowing transplants for Model for End-Stage Liver Disease(MELD) ≤ 14(Rule 14). The differential impact of the rule changes was assessed.RESULTS: The Markov simulation accurately reproduced overall and post transplant survival. A 1200 D-MELD risk cap improved post-transplant survival. Both the 1200 and 1600 risk caps improved overall survival for waitlisted patients. The addition of Rule 14 further improved post transplant and overall survival by redistribution of donor livers to recipients in higher MELD subgroups. The mechanism for improved overall and post-transplant survival after listing was due to shifting a larger percentage of transplants to the moderate MELD score subgroup(MELD 15-29) while also ensuring that high MELD recipients have livers of high quality to achieve excellent post transplant survival.CONCLUSION: A 1200 D-MELD risk cap + Rule 14 provided the greatest overall benefit primarily by focusing liver transplantation towards the moderate MELD recipient. | Jeffrey B Halldorson Robert L Carithers Jr Renuka Bhattacharya Ramasamy Bakthavatsalam Iris W Liou Andre A Dick Jorge D Reyes James D Perkins | 2014 | World Journal of Transplantation2014，4，3： | 2 |
| 4 | The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) functions as a dominant regulator of apoptosis in hippocampal neurons Involving activation of the ERK sur- vival pathway and upregulation of the antiapoptotic protein Bag-1 显示文摘 | Perkins D Pereira EFR Aurelian L | 2003 | Journal of virology2003，77，2： | 1 |
| 5 | Metastability in Near-surface Rocks of Minerals in the System Al2O3-SiO2-H2O显示文摘 | Anovitz L M Perkins D Essene E J | | 0，，39： | 1 |
| 6 | Oxidation of elemental mercury by hydroperoxides in aqueous solutions 显示文摘 | Wigfield D C Perkins S L | 1985 | Canadian Journal of Chemistry1985，63，： | 1 |
| 7 | Finding common ground : The importance of place attachment to community participation and planning 显示文摘 | Manzo L C Perkins D D | 2006 | Journal of Plan- ning Literature2006，20，4： | 1 |
| 8 | Regulation of cyclin D1 gene expression显示文摘 | WlTZEL I I KOH L F PERKINS N D | 2010 | Biochem Soc Trans2010，38，： | 1 |
| 9 | Catalysis at the metal-support interface exemplified by the photocatalytic reforming of methanol on Pd/TiO2显示文摘 | BOWKER M JAMES D STONE P BENNETT R PERKINS N MILLARD L GREAVES J DICKINSON A | 2003 | J Catal2003，217，2： | 1 |
| 10 | A new sparsity preserving quasi-Newton update for solving nonlinear equations显示文摘 | Bogle I D L Perkins J D | 1990 | SIAM J Sci Statist Comp1990，11，： | 1 |
| 11 | Paelitaxel-Induced Apoptosis and Mitotic Arrest Assessed by Serial Fine-Needle Aspiration : Implications for Early Prediction of Breast Cancer Response to Neoadjuvant Treatment 显示文摘 | SYMMANS W F VOLM M D SHAPIRO R L PERKINS A B KIM A Y DEMARIA S YEE H T MCMULLEN H ORATZ R KLEIN P FORMENTI S C MUGGIA F | 2000 | Clin Cancer Res2000，6，12： | 1 |
| 12 | Herpes simplex virus type 1 ICP27 regulates expression of a variant, secreted form of glycoprotein C by an intron retention mechanism显示文摘 | Sedlackova L Perkins K D Lengyel J | 2008 | J Virol2008，82，15： | 1 |
| 13 | Analysis of robust innale immune response after transplantation in the absence of adaptive immunity 显示文摘 | HE H STONE J R PERKINS D L | 2002 | Transplantation2002，73，6： | 1 |
| 14 | Regulation of cyclin D1 gene expression显示文摘 | Witzel I I Koh L F Perkins N D | 2010 | Biochem Soc Trans2010，38，1： | 1 |
| 15 | Comparison of the ABI 7700 system (TaqMan) and competitive PCR for quantitation of IS6110 DNA in sputum during treatment of tuberculosis显示文摘 | Desjardin L E Chen Y Perkins M D | 1998 | J Clin Mierobiol1998，36，： | 1 |
| 16 | Microbial markers as surrogates for response to chemotherapy of tuberculosis显示文摘 | Des Jardin L E Chen Y Perkins M D | 1996 | Am J Respir Crit Care Med1996，155，1： | 1 |
| 17 | Histogenetic phenotypes of B cells in posttransplant lymphoproliferative disorders by immunohistochemical analysis correlate with transplant type:solid organ vs hematopoietic stem cell transplantation显示文摘 | Novoa-Takara L Perkins SL Qi D | | 0，，01： | 1 |
| 18 | Adolescent Place Attachment, Social Capital, and Perceived Safety : A Comparison of 13 Countries显示文摘 | DALLAGO L PERKINS D D SANTINELLO M | 2009 | American Journal of Community Psychology2009，44，1： | 1 |
| 19 | Combinatorial studies of Zn-Al-O and Zn-Sn-O transparent conducting oxide thin films显示文摘 | del Cueto J Alleman J L | 2002 | Thin Solid Films2002，4，11： | 1 |
| 20 | The herpes simplex virus type 2 R1 protein kinase (ICPI0 PK) functions as a dominant regulator of apoptosis in hippocampal neurons involving activation of the ERK survival pathway and upregulation of the antiapoptotic protein Bag-1 显示文摘 | PERKINS D PEREIRA EFR AURELIAN L | 2003 | Journal of Virology2003，77，2： | 1 |
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