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| 1 | Recent trends in liver transplantation for alcoholic liver disease in the United States显示文摘AIM To examine temporal changes in the indications for liver transplantation(LT) and characteristics of patients transplanted for alcoholic liver disease(ALD).METHODS We performed a retrospective cohort analysis of trends in the indication for LT using the United Network for Organ Sharing(UNOS) database between 2002 and 2015. Patients were grouped by etiology of the liver disease and characteristics were compared using χ~2 and t-tests. Time series analysis was used identifying any year with a significant change in the number of transplants per year for ALD, and before and after eras were modeled using a general linear model. Subgroup analysis of recipients with ALD was performed by age group, gender, UNOS region and etiology(alcoholic cirrhosis, alcoholic hepatitis and hepatitis C-alcoholic cirrhosis dual listing).RESULTS Of 74216 liver transplant recipients, ALD(n = 9400, 12.7%) was the third leading indication for transplant after hepatitis C and hepatocellular carcinoma. Transplants for ALD, increased from 12.8%(553) in 2002 to 16.5%(1020) in 2015. Time series analysis indicated a significant increase in the number of transplants per year for ALD in 2013(P = 0.03). There were a stable number of transplants per year between 2002 and 2012(linear coefficient 3, 95%CI:-4.6, 11.2) an increase of 177 per year between 2013 and 2015(95%CI: 119, 234). This increase was significant for all age groups except those 71-83 years old, was observed for both genders, and was incompletely explained by a decrease in transplants for hepatitis C and ALD dual listing. All UNOS regions except region 9 saw an increase in the mean number of transplants per year when comparing eras, and this increase was significant in regions 2, 3, 4, 5, 6, 8, 10 and 11.CONCLUSION There has been a dramatic increase in the number of transplants for ALD starting in 2013. | Catherine E Kling James D Perkins Robert L Carithers Dennis M Donovan Lena Sibulesky | 2017 | World Journal of Hepatology2017，9，36： | 6 |
| 2 | Genome-level analysis of genetic regulation of liver gene expression networks显示文摘 | Gatti, D Maki, A Chesler, EJ Kirova, R Kosyk, O Lu, L Williams, RW Perkins, A Langston, MA Threadgill, DW Rusyn, I | 2007 | 中国生物学文摘2007，21，11： | 3 |
| 3 | D-MELD risk capping improves post-transplant and overall mortality under markov microsimulation显示文摘AIM: To hypothesize that the product of calculated Model for End-Stage Liver Disease score excluding exception points and donor age(D-MELD) risk capping ± Rule 14 could improve post liver transplant and overall survival after listing.METHODS: Probabilities derived from the United Network for Organ Sharing database between 2002 and 2004 were used to simulate potential outcomes for all patients listed for transplantation. The Markov simula-tion was then modified by screening matches using a 1200 or 1600 D-MELD risk cap ± allowing transplants for Model for End-Stage Liver Disease(MELD) ≤ 14(Rule 14). The differential impact of the rule changes was assessed.RESULTS: The Markov simulation accurately reproduced overall and post transplant survival. A 1200 D-MELD risk cap improved post-transplant survival. Both the 1200 and 1600 risk caps improved overall survival for waitlisted patients. The addition of Rule 14 further improved post transplant and overall survival by redistribution of donor livers to recipients in higher MELD subgroups. The mechanism for improved overall and post-transplant survival after listing was due to shifting a larger percentage of transplants to the moderate MELD score subgroup(MELD 15-29) while also ensuring that high MELD recipients have livers of high quality to achieve excellent post transplant survival.CONCLUSION: A 1200 D-MELD risk cap + Rule 14 provided the greatest overall benefit primarily by focusing liver transplantation towards the moderate MELD recipient. | Jeffrey B Halldorson Robert L Carithers Jr Renuka Bhattacharya Ramasamy Bakthavatsalam Iris W Liou Andre A Dick Jorge D Reyes James D Perkins | 2014 | World Journal of Transplantation2014，4，3： | 2 |
| 4 | Probability-based protein identification by searching sequence databases using mass spectrometry data显示文摘 | Pappin D J Creasy D M | 1999 | Electrophoresis1999，，20： | 1 |
| 5 | Studies of wax deposi tion in the Trans-Alaska Pipeline显示文摘 | Burger E D Perkins T K Striegler J H | 1981 | Journal of Petroleum Tech nology1981，33，6： | 1 |
| 6 | The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) functions as a dominant regulator of apoptosis in hippocampal neurons Involving activation of the ERK sur- vival pathway and upregulation of the antiapoptotic protein Bag-1 显示文摘 | Perkins D Pereira EFR Aurelian L | 2003 | Journal of virology2003，77，2： | 1 |
| 7 | In vivo and in vitro effects of salbutamol on alveolar epithelial repair in acute lung injury显示文摘 | Perkins G D Gao F Thickett D R | | 0，，03： | 1 |
| 8 | Metastability in Near-surface Rocks of Minerals in the System Al2O3-SiO2-H2O显示文摘 | Anovitz L M Perkins D Essene E J | | 0，，39： | 1 |
| 9 | Integrating cell-signalling pathways with NF-kappaB and IKK function显示文摘 | PERKINS N D | 2007 | Nat Rev Mol Cell Biol2007，8，1： | 1 |
| 10 | Optimal grade transition and selection of closed-loop controllers in a gas-phase olefin polymerization fluidized bed reactor显示文摘 | CHATZIDOUKAS C PERKINS J D PISTIKOPOULOS E N | 2003 | Chemical Engineering Science2003，58，16： | 1 |
| 11 | Oxidation of elemental mercury by hydroperoxides in aqueous solutions 显示文摘 | Wigfield D C Perkins S L | 1985 | Canadian Journal of Chemistry1985，63，： | 1 |
| 12 | Controlled trial prednisolone in acute polyneuropathy显示文摘 | Hughes R A Newsom-Davis J M Perkin G D | 1978 | Lancet1978，2，： | 1 |
| 13 | NF - kappaB: tumor promoter or suppressor? 显示文摘 | PERKINS N D | 2004 | Trends Cell Biol2004，14，2： | 1 |
| 14 | Do grain boundaries affect microwave dielectric loss in oxides 显示文摘 | BREEZE J D PERKINS J M MCCOMB D W | 2009 | J Am Ceram Soe2009，92，3： | 1 |
| 15 | Rec- net Advances in Optimization - Based Simultaneous Process and Control Design 显示文摘 | Vassilis Sakizlis John D Perkins Efstratios N Pistikopoulos | 2004 | Computers and Chemical Engineering2004，28，10： | 1 |
| 16 | Finding common ground : The importance of place attachment to community participation and planning 显示文摘 | Manzo L C Perkins D D | 2006 | Journal of Plan- ning Literature2006，20，4： | 1 |
| 17 | The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) blocks apoptosis in hippocampal neurons, involving activation of the MEK/MAPK survival pathway 显示文摘 | Perkins D Pereira E F Gober M | 2002 | J Virol2002，76，3： | 1 |
| 18 | Analysis of resonant coupled coils in the design of radio frequency transcutaneous links 显示文摘 | Donaldson N D Perkins T A | 1983 | Medical and Biological Engineering and Computing1983，21，5： | 1 |
| 19 | Regulation of cyclin D1 gene expression显示文摘 | WlTZEL I I KOH L F PERKINS N D | 2010 | Biochem Soc Trans2010，38，： | 1 |
| 20 | Probability-based protein identification by searching sequence databases using mass spectrometry data显示文摘 | Perkins DN Pappin D J Creasy DM Cottrell JS | 1999 | Electrophoresis1999，20，18： | 1 |
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