|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets显示文摘 | Hommes D W Peppelenbosch M P van Deventer S J | 2003 | Gut2003，52，1： | 14 |
| 2 | Bone morphogenetic protein-2 is a negative regulator of hepatocyte proliferation downregulated in the regenerating liver显示文摘AIM: To characterize the expression and dynamic changes of bone morphogenetic protein (BMP)-2 in hepatocytes in the regenerating liver in rats after partial hepatectomy (PH), and examine the effects of BMP-2 on proliferation of human Huh7 hepatoma cells. METHODS: Fifty-four adult male Wistar rats were randomly divided into three groups: A normal control (NC) group, a partial hepatectomized (PH) group and a sham operated (SO) group. To study the effect of liver regeneration on BMP-2 expression, rats were sacrificed before and at different time points after PH or the sham intervention (6, 12, 24 and 48 h). For each time point, six rats were used in parallel. Expression and distribution of BMP-2 protein were determined in regenerating liver tissue by Western blot analysis and immunohistochemistry. Effects of BMP-2 on cell proliferation of human Huh7 hepatoma cell line were assessed using an MTT assay.RESULTS: In the normal liver strong BMP-2 expression was observed around the central and portal veins. The expression of BMP-2 decreased rapidly as measured by both immunohistochemistry and Western blot analysis. This decrease was at a maximum of 3.22 fold after 12 h and returned to normal levels at 48 h after PH. No significant changes in BMP-2 immunoreactivity were observed in the SO group. BMP-2 inhibited serum induced Huh7 cell proliferation.CONCLUSION: BMP-2 is expressed in normal adult rat liver and negatively regulates hepatocyte proliferation. The observed down regulation of BMP-2 following partial hepatectomy suggests that such down regulation may be necessary for hepatocyte proliferation. | Cui-Ping Xu Wen-Min Ji Gijs R van den Brink Maikel P Peppelenbosch | 2006 | World Journal of Gastroenterology2006，12，47： | 10 |
| 3 | Telaprevir/boceprevir era: From bench to bed and back显示文摘Hepatitis C virus (HCV) infects approximately 200 million people worldwide. Interferon-based therapies have dominated over the past two decades. However, the overall response rates remain suboptimal. Thanks to the tremendous effort from both academia and industry, two serine protease inhibitors telaprevir and boceprevir for treating chronic hepatitis C have finally reached the clinic. Although these compounds are only approved for combination use with interferon and ribavirin in genotype 1 HCV infected chronic patients, the management of HCV patients however is now evolving incredibly. Here, we overviewed a series of landmark studies, regarding the clinical development of telaprevir and boceprevir. We discussed the mechanism-of-action of telaprevir/boceprevir and their potential application in HCV-positive liver transplantation patients. We further emphasized some emerging concerns with perspective of further development in this field. | Maikel P Peppelenbosch Harry LA Janssen Robert J de Knegt | 2012 | World Journal of Gastroenterology2012，18，43： | 3 |
| 4 | CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL. | Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed | 2018 | Cellular & Molecular Immunology2018，15，2： | 2 |
| 5 | Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets显示文摘 | Hommes D Peppelenbosch M van Deventer S | 2003 | Gut2003，52，1： | 1 |
| 6 | Inflammatory signal transduction in Crohn's disease and novel therapeutic approaches显示文摘 | Van Montfrans C Peppelenbosch M Te Velde A A | 2002 | Biochem Pharmacol2002，64，： | 1 |
| 7 | Functional genomic analyses of the gut microbiota for CRC screening显示文摘 | Konstantinov S R Kuipers E J Peppelenbosch M P | 2013 | Nature Reviews Gastroenterology & Hepatology2013，10，12： | 1 |
| 8 | Tissue factor signal transduction in angiogenesis显示文摘 | Versteeg HH Peppelenbosch MP Spek CA | 2003 | Carciogenesis2003，24，6： | 1 |
| 9 | Tissue factor and cancer metastasis:the role of intracellular and extracellular signaling pathways显示文摘 | Versteeg HH Spek CA Peppelenbosch MP | 2004 | Mol Med2004，10，： | 1 |
| 10 | SOCS3 in immune regulation of inflammatory bowel disease and inflammatory bowel disease-related cancer 显示文摘 | Li Y de Haar C Peppelenbosch MP | 2012 | Cytokine Growth Factor Rev2012，23，3： | 1 |
| 11 | Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-in- dueed colitis显示文摘 | Camoglio L Juffermans NP Peppelenbosch M | 2002 | Eur J Inanunol2002，32，1： | 1 |
| 12 | Anchoring skeletal muscledevelopment and disease:the role of ankyrin repeat domiancontaining proteins in muscle physiology显示文摘 | TEE J M PEPPELENBOSCH M P | 2010 | Critical Reviews inBiochemistry and Molecular Biology2010，45，4： | 1 |
| 13 | Surgical or endovascular repair of thrombosed dialysis vascular access: Is there any evidence?显示文摘 | Jan H.M. Tordoir Aron S. Bode Noud Peppelenbosch Frank M. van der Sande Michiel W. de Haan | 2009 | Journal of Vascular Surgery2009，，： | 1 |
| 14 | LPS signal transduction:the picture is becoming more complex显示文摘 | DIKS SH RICHEL DI PEPPELENBOSCH MP | | 0，，11： | 1 |
| 15 | Hedgehog morphogen in cardiovascular disease 显示文摘 | BIJLSMA M F PEPPELENBOSCH M P SPEK C A | 2006 | Circulation2006，114，18： | 1 |
| 16 | Tissue factor and cancer metastasis: the role of intracellular and extracellular signaling pathways显示文摘 | Versteeg H H Spek C A Peppelenbosch M P | 2004 | Mol Med2004，10，16： | 1 |
| 17 | Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn' s disease 显示文摘 | ten Hove T van Montfrans C Peppelenbosch M P | 2002 | Gut2002，50，2： | 1 |
| 18 | Kinome profiling of non-canonical TRAIL signaling reveals RIP1-Src-STAT3-dependent invasion in resistant non-small cell lung cancer cells显示文摘 | Azijli K Peppelenbosch MP Dekker H | 2012 | J Cell Sci2012，125，19： | 1 |
| 19 | Neuronal differentiation of embryonic stem cells显示文摘 | Van Inzen WG Peppelenbosch MP Van Den Brand MW l | 1996 | Biochim Biophys Acta1996，1312，1： | 1 |
| 20 | Kinome profiling of non-canonical TRAIL signaling reveals RIPI-Src- STAT3-dependent invasion in resistant non-small cell lung cancer cells显示文摘 | Azij:i K Yuvaraj S Peppelenbosch MP | 2012 | J Cell Sci2012，125，19： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员