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| 1 | 颈椎前路减压融合术对颈椎病眩晕患者的缓解效果——多中心前瞻性队列研究显示文摘颈椎病患者除颈部疼痛外常伴有眩晕症状,这种颈源性眩晕并非由前庭病理引起。研究表明,退行性椎间盘突出症与颈椎病患者的退行性眩晕有关,而颈椎前路椎间盘切除融合手术可缓解这一症状。本项多中心队列研究的目的在于分析颈椎前路减压(anterior cervical decompression,ACD)手术对颈源性眩晕的缓解效果,同时探讨其发病机制。 | Peng B Yang L Yang C 李洪吉 王建华 | 2018 | 中国骨科临床与基础研究杂志2018，10，4： | 15 |
| 2 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 3 | SPSBl-mediated HnRNP A1 alternative splicing and cell ubiquitylation regulates migration in EGF signaling显示文摘细胞外的信号被显示了影响拼接的其他的 pre-mRNA;然而,分子的机制和导致信号的拼接的规定的生物意义仍然保持大部分未知。这里,我们报导那个表皮的生长因素(EGF ) 通过一个著名拼接管理者的 ubiquitylation 导致拼接的变化, hnRNP A1。EGF 发信号 upregulates 一个 E3 ubiquitin (Ub ) ligase 适配器,敏捷的包含域的 SOCS 盒子蛋白质 1 (SPSB1 ) ,它结合离氨酸 29 连接 polyUb 链到 hnRNP A1 上的成员 Elongin B/C-Cullin 建筑群。重要地, hnRNP A1 的 SPSB1 和 ubiquitylation 在驾驶 EGF 的房间移植有一个关键角色。机械学地,和 SR 蛋白质 kinases (SRPK ) 的激活的 hnRNP A1 的导致 EGF 的 ubiquitylation 导致拼接的 Rac1 的 upregulation isoform, Rac1b,支持房间活动性。这些调查结果解开在蛋白质 ubiquitylation 并且在 EGF/EGF 受体发信号的其他的拼接之间的新奇串音,并且在 modulating 房间移植识别新 EGF/SPSB1/hnRNP A1/Rac1 轴,它可以为癌症治疗有重要含意。 | Feng Wang Xing Fu Peng Chen Ping Wu Xiaojuan Fan Na Li Hong Zhu Ting-Ting Jia Hongbin Ji Zefeng Wang Catherine C L Wong Ronggui Hu Jingyi Hui | 2017 | Cell Research2017，27，4： | 5 |
| 4 | Adaptive guaranteed cost control of systems with uncertain parameters显示文摘 | Chang M S L Peng T K C | 1972 | IEEE Transactions on Automatic Control1972，17，4： | 2 |
| 5 | Studies on 6,6￠-di-substituted Effects of the dpq in2+ with DFT method显示文摘 | ZHENG K C WANG J P PENG W L | 2001 | J Phys Chem A2001，105，10： | 1 |
| 6 | Characterization and degradation behavior of AZ31 alloy surface modified by bone-like hydroxyapatite for implant applications显示文摘 | Wen C L Guan S K Peng L et at | 2009 | Applied Surface Science2009，255，1314： | 1 |
| 7 | PBDEs in sediments of the Beijiang River,China: levels,distribution,and influence of total organic carbon 显示文摘 | CHEN L G HUANG Y M PENG X C | 2009 | Chemosphere2009，76，2： | 1 |
| 8 | Synthesis of Eu3+-activated yttrium oxysulfide red phosphor by flux fusion method显示文摘 | LO C L DUH J G CHIOU B S PENG C C | 2001 | Chemistry and Physics2001，71，： | 1 |
| 9 | Pectin transitions during blueberry fruit development and ripening 显示文摘 | Proctor A Peng L C | 1989 | J Food Sci1989，54，： | 1 |
| 10 | Molecular analysis of cellulose biosynthesis in Arabidopsis显示文摘 | ARIOLI T PENG L BETZNER A S BURN J WITTKE W HERTH W CAMILLERI C H(O)FTE H PLAZINSKI J BIRCH R CORKA GLOVER J REDMOND J WILLIAMSDN R E | 1998 | Science1998，279，： | 1 |
| 11 | Self-assembled star-shaped chlorin-core poly (6-caprolaetone) -poly ( ethyleneglycol ) diblock copolymer micelles for dual ehemo-photodynamic therapies 显示文摘 | Peng C L Shieh M J Tsai M H | 2008 | Biomaterials2008，29，26： | 1 |
| 12 | Study on combined control of regenerative braking and antilock braking system for hy- brid electric vehicles 显示文摘 | Peng D Zhang Y Yin C L | 2008 | International Journal of Automo- tive Technology2008，9，6： | 1 |
| 13 | Temperature- and duration- dependent rice straw-derived biochar: Characteristics and its effects on soil properties of an UltisoI in southern China显示文摘 | PENG X YE L L WANG C H | 2011 | Soil & Tillage Research2011，112，： | 1 |
| 14 | Adaptive guaranteed cost control of systems with uncertain parameters显示文摘 | Chang S S L Peng T K C | | 0，，04： | 1 |
| 15 | Multiscale entropy analysis of complex physiologic time series显示文摘 | Costa M Goldberger A L Peng C K | 2002 | Physical Review Letter2002，89，6： | 1 |
| 16 | Effect of Fe3 04 addition on removal of ammonium by zeolite NaA 显示文摘 | LIU H B PENG S C SHU L | 2013 | Journal of Colloid and Interface Science2013，390，1： | 1 |
| 17 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 18 | State feedback controller design of networked control systems 显示文摘 | Yue D Han Q L Peng C | 2004 | IEEE Trans on Circuits and Systems: Ⅱ2004，51，11： | 1 |
| 19 | Biaxial contouring control with friction dynamics using a contour index approach显示文摘 | PENG C C CHEN C L | 2007 | International Journal of Machine Tools and Manufacture2007，47，10： | 1 |
| 20 | Fabrication of Ti3AIC powder with high-purity by pressureless sintering 显示文摘 | PENG C WANG C QI L | 2004 | Materials Science Forum2004，，： | 1 |
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