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| 1 | 颈椎前路减压融合术对颈椎病眩晕患者的缓解效果——多中心前瞻性队列研究显示文摘颈椎病患者除颈部疼痛外常伴有眩晕症状,这种颈源性眩晕并非由前庭病理引起。研究表明,退行性椎间盘突出症与颈椎病患者的退行性眩晕有关,而颈椎前路椎间盘切除融合手术可缓解这一症状。本项多中心队列研究的目的在于分析颈椎前路减压(anterior cervical decompression,ACD)手术对颈源性眩晕的缓解效果,同时探讨其发病机制。 | Peng B Yang L Yang C 李洪吉 王建华 | 2018 | 中国骨科临床与基础研究杂志2018，10，4： | 15 |
| 2 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 3 | Mapping landslide susceptibility at the Three Gorges Reservoir, China, using gradient boosting decision tree,random forest and information value models显示文摘This work was to generate landslide susceptibility maps for the Three Gorges Reservoir(TGR) area, China by using different machine learning models. Three advanced machine learning methods, namely, gradient boosting decision tree(GBDT), random forest(RF) and information value(InV) models, were used, and the performances were assessed and compared. In total, 202 landslides were mapped by using a series of field surveys, aerial photographs, and reviews of historical and bibliographical data. Nine causative factors were then considered in landslide susceptibility map generation by using the GBDT, RF and InV models. All of the maps of the causative factors were resampled to a resolution of 28.5 m. Of the 486289 pixels in the area,28526 pixels were landslide pixels, and 457763 pixels were non-landslide pixels. Finally, landslide susceptibility maps were generated by using the three machine learning models, and their performances were assessed through receiver operating characteristic(ROC) curves, the sensitivity, specificity,overall accuracy(OA), and kappa coefficient(KAPPA). The results showed that the GBDT, RF and In V models in overall produced reasonable accurate landslide susceptibility maps. Among these three methods, the GBDT method outperforms the other two machine learning methods, which can provide strong technical support for producing landslide susceptibility maps in TGR. | CHEN Tao ZHU Li NIU Rui-qing TRINDER C John PENG Ling LEI Tao | 2020 | Journal of Mountain Science2020，17，3： | 7 |
| 4 | 甲醇合成反应热力学分析及实验研究显示文摘比较了近年来文献中甲醇合成反应平衡常数的各种计算方法 ,采用固定床反应器在反应温度为 2 30~ 2 70℃和反应压力为 5~ 8MPa的条件下对甲醇合成反应热力学进行了实验研究。结果表明 ,不同计算方法的预测结果存在较大的差异 ,而采用 Reid的热容数据及 SRK方程得到的计算结果与实验结果吻合很好 。 | 刁杰 王金福 王志良 金涌 John C Tao Xiang-Dong Peng | 2001 | 化学反应工程与工艺2001，17，1： | 7 |
| 5 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 6 | Distinct regulatory mechanism of immunoglobulin gene transcription in epithelial cancer cells显示文摘The restriction of immunoglobulin(Ig)expression to B lymphocytes is well established.However,several reports have confirmed that the Ig gene can be expressed in many non-B cancer cells and/or some normal cells.Our aim is to determine whether the Ig gene promoter can be activated in non-B cancer cells and to identify the regulatory mechanism for Ig gene expression.Our results show that the Ig promoter of VH4-59 was activated in several non-B cancer cell lines.Moreover,two novel positive regulatory elements,an enhancer-like element at 2800 to 2610 bp and a copromoter-like element at 2610 to 2300 bp,were identified in two epithelial cancer cell lines,HeLa S3 and HT-29.The octamer element(59-ATGCAAAT-39)located in the Ig promoter,a crucial element for B-cell-derived Ig gene transcription,was also very important for non-B-cell-derived Ig gene transcription.More importantly,we confirmed that octamer-related protein-1(Oct-1),but not Oct-2,was a crucial transcriptional factor for Ig gene transcription due to its ability to bind to the octamer element of the Ig promoter in epithelial cancer cells.These results suggested the presence of a distinct regulatory mechanism for Ig gene expression in non-B cancer cells. | Xiaohui Zhu Lina Wu Li Zhang Peng Hao Shuai Zhang Jing Huang Jie Zheng Yinan Liu Wenjun Li Yingmei Zhang Chunyan Zhou Youhui Zhang C Cameron Yin Xiaoyan Qiu | 2010 | Cellular & Molecular Immunology2010，7，4： | 5 |
| 7 | 新型泛过氧化物酶体增殖物激活受体激动剂MBT1805对α-萘异硫氰酸酯诱导的小鼠胆汁淤积症的治疗作用显示文摘【据Frontiers in Pharmacology 2021年10月报道】代谢组学分析揭示了新型泛过氧化物酶体增殖物激活受体激动剂MBT1805对α-萘异硫氰酸酯诱导的小鼠胆汁淤积症的治疗作用(作者Wang C等)胆汁淤积性肝损伤的治疗药物相对缺乏。 | WANG C PENG F ZHONG B 王畅 | 2021 | 临床肝胆病杂志2021，37，12： | 5 |
| 8 | Energy Efficient Run-Time Incremental Mapping for 3-D Networks-on-Chip显示文摘3-D Networks-on-Chip(NoC) emerge as a potent solution to address both the interconnection and design complexity problems facing future Multiprocessor System-on-Chips(MPSoCs).Effective run-time mapping on such 3-D NoC-based MPSoCs can be quite challenging,as the arrival order and task graphs of the target applications are typically not known a priori,which can be further complicated by stringent energy requirements for NoC systems.This paper thus presents an energy-aware run-time incremental mapping algorithm(ERIM) for 3-D NoC which can minimize the energy consumption due to the data communications among processor cores,while reducing the fragmentation effect on the incoming applications to be mapped,and simultaneously satisfying the thermal constraints imposed on each incoming application.Specifically,incoming applications are mapped to cuboid tile regions for lower energy consumption of communication and the minimal routing.Fragment tiles due to system fragmentation can be gleaned for better resource utilization.Extensive experiments have been conducted to evaluate the performance of the proposed algorithm ERIM,and the results are compared against the optimal mapping algorithm(branch-and-bound) and two heuristic algorithms(TB and TL).The experiments show that ERIM outperforms TB and TL methods with significant energy saving(more than 10%),much reduced average response time,and improved system utilization. | Xiao-Hang Wang Peng Liu Mei Yang Maurizio Palesi Ying-Tao Jiang Michael C Huang | 2013 | Journal of Computer Science & Technology2013，28，1： | 5 |
| 9 | SPSBl-mediated HnRNP A1 alternative splicing and cell ubiquitylation regulates migration in EGF signaling显示文摘细胞外的信号被显示了影响拼接的其他的 pre-mRNA;然而,分子的机制和导致信号的拼接的规定的生物意义仍然保持大部分未知。这里,我们报导那个表皮的生长因素(EGF ) 通过一个著名拼接管理者的 ubiquitylation 导致拼接的变化, hnRNP A1。EGF 发信号 upregulates 一个 E3 ubiquitin (Ub ) ligase 适配器,敏捷的包含域的 SOCS 盒子蛋白质 1 (SPSB1 ) ,它结合离氨酸 29 连接 polyUb 链到 hnRNP A1 上的成员 Elongin B/C-Cullin 建筑群。重要地, hnRNP A1 的 SPSB1 和 ubiquitylation 在驾驶 EGF 的房间移植有一个关键角色。机械学地,和 SR 蛋白质 kinases (SRPK ) 的激活的 hnRNP A1 的导致 EGF 的 ubiquitylation 导致拼接的 Rac1 的 upregulation isoform, Rac1b,支持房间活动性。这些调查结果解开在蛋白质 ubiquitylation 并且在 EGF/EGF 受体发信号的其他的拼接之间的新奇串音,并且在 modulating 房间移植识别新 EGF/SPSB1/hnRNP A1/Rac1 轴,它可以为癌症治疗有重要含意。 | Feng Wang Xing Fu Peng Chen Ping Wu Xiaojuan Fan Na Li Hong Zhu Ting-Ting Jia Hongbin Ji Zefeng Wang Catherine C L Wong Ronggui Hu Jingyi Hui | 2017 | Cell Research2017，27，4： | 5 |
| 10 | Effect of Temperature and Strain Rate on Dynamic Properties of Low Silicon TRIP Steel显示文摘The dynamic tensile test of 0·11C-0·62Si-1·65 Mn TRIP steel was carried out at different strain ratesand test temperatures . The results showthat both temperature and strain rate affect the retained austenite trans-formation . At high strain rates ,the uniformelongation decreases , whereas the total elongation and energy absorp-tionincrease . The tensile strengthis less strain rate sensitive . With raising test temperature ,the tensile strengthis reduced and the mechanical properties generally deteriorate ,especially at 110 ℃. However ,excellent mechani-cal properties were obtained at 50 ℃and 75 ℃. | TIAN Rong LI Lin B C De Cooman WEI Xi-chen SUN Peng | 2006 | Journal of Iron and Steel Research(International)2006，13，3： | 5 |
| 11 | New and efficient large-update interior-point method for linear optimization 显示文摘 | PENG J M ROOS C TERLAKY T | 2001 | J Comput Technol2001，4，： | 2 |
| 12 | Adaptive guaranteed cost control of systems with uncertain parameters显示文摘 | Chang M S L Peng T K C | 1972 | IEEE Transactions on Automatic Control1972，17，4： | 2 |
| 13 | Nitrification at low oxygen concentration in biofilm reactor 显示文摘 | Bernet N Peng D C Delgenes J P | 2001 | J Environ Eng ASCE2001，127，3： | 1 |
| 14 | Chlorophyll meter estimates leaf area based nitrogen concentration of rice 显示文摘 | Peng S B Laza R C Garcia F V | 1995 | Communication of Soil Science and Plant Analysis1995，26，： | 1 |
| 15 | Theoretical studies on molecular structure and vibrational spectra of copper phthalocyanine 显示文摘 | LID C PENG Z H | 2005 | Vibrational Spectroscopy2005，39，2： | 1 |
| 16 | Nitrification at low oxygen concentration in biofilm reactor显示文摘 | Bernet N Peng D C Delgenes J P | 2001 | J Environ Eng2001，127，3： | 1 |
| 17 | White spot syndrome baculovirus(WSBV) detected in cultured and captured shrimp, crabs and other arthropods 显示文摘 | Lo C F Ho C H Peng S E | 1996 | Dis Aquat Org1996，27，： | 1 |
| 18 | The physicochemie, al and functional properties of soybean 11S globulin-a review 显示文摘 | Peng I C Quass D W Dayton W R | 1984 | Cereal Chemistry1984，61，6： | 1 |
| 19 | Epitaxial growth of highly luminescent CdSe/CdS core/shell nanocrystals with photostability and electronic accessibility显示文摘 | Schlamp M C Kadavanich A V | 1997 | J Am Chem Soc1997，119，： | 1 |
| 20 | Studies on 6,6￠-di-substituted Effects of the dpq in2+ with DFT method显示文摘 | ZHENG K C WANG J P PENG W L | 2001 | J Phys Chem A2001，105，10： | 1 |
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