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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | C-reactive protein and reclassification of cardiovascular risk in the Framingham Heart Study显示文摘 | Wilson PW Pencina M Jacques P | 2008 | Circ Cardiovasc Qual Outcomes2008，1，2： | 1 |
| 3 | Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts 显示文摘 | Bhasin S Pencina M Jasuja GK | 2011 | J Clin Endoerinol Metab2011，96，8： | 1 |
| 4 | Vitamin D deficiency and risk of cardiovascular disease 显示文摘 | Wang TJ Pencina M J Booth SL | 2008 | Circulation2008，117，4： | 1 |
| 5 | C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study显示文摘 | Wilson PW Nam BH Pencina M | 2005 | Arch Intern Med2005，165，21： | 1 |
| 6 | General cardiovascular risk profile for use in primary care: the Framingham Heart Study显示文摘 | D' Agostino R B Sr Vasan R S Pencina M J | 2008 | Circulation2008，117，6： | 1 |
| 7 | Associations of carotid artery intima-media thickness (IMT) with risk factors and preva- lent cardiovascular disease: comparison of mean common carotid artery IMT with maximum internal carotid artery IMT显示文摘 | Polak J F Pencina M J Meisner A | 2010 | Ultra- sound Med2010，29，： | 1 |
| 8 | General cardiovascular risk profile for use in primary care:the Framingham Heart Study显示文摘 | D'Agostino R B Sr Vasan R S Pencina M J | 2008 | Circulation2008，117，6： | 1 |
| 9 | Impact of impaired fasting glucose on cardiovascular disease : the Framingham Heart Study 显示文摘 | Levitzky Y S Pencina M J DAgostino R B | 2008 | J AM ColICardio12008，51，15： | 1 |
| 10 | Impact of impaired fast- ing glucose on cardiovascular disease 显示文摘 | Levitzky YS Pencina M J Meigs JB | 2008 | JACC2008，51，4： | 1 |
| 11 | General cardiovascular risk profile for use in primary care:the Framingham Heart Study显示文摘 | D’AGOSTINO R B S R VASAN R S PENCINA M J | 2008 | Circulation2008，117，6： | 1 |
| 12 | Carotid-wall intima-media thickness and cardiovascular events 显示文摘 | Polak J F Pencina M T Pencina K M | 2011 | N En- gl J Med2011，365，3： | 1 |
| 13 | Carotid-wall intima-media thickness and cardiovascular events 显示文摘 | Joseph F Polak Michael J Pencina Karol M | 2011 | New Eng- land Journal of Medicine2011，365，3： | 1 |
| 14 | Sex hormone-binding globulin,but not testosterone,is associated prospectively and independently with incident metabolic syndrome in men显示文摘 | Bhasin S Jasjua GK Pencina M | 2011 | Diabetes Care2011，34，11： | 1 |
| 15 | Association of parental hypertension with concentrations of select biomarkers in nonhy- pertensive offspring显示文摘 | Lieb W Pencina M J Wang TJ | 2008 | Hyperten - sion2008，52，2： | 1 |
| 16 | C-reactive pro- tein and reclassification of cardiovascular risk in the Framingham Heart Study 显示文摘 | Wilson PW Pencina M Jacques P | 2008 | Cric Cardiovasc Qual Qut- comes2008，1，2： | 1 |
| 17 | Sex hormone-binding globulin,but not testosterone,is associated prospectively and independently with incident metabolic syndrome in men:the framingham heart study显示文摘 | Bhasin S Jasjua GK Pencina M | | 0，，11： | 1 |
| 18 | Impact of impaired fasting glucose on cardiovascular disease : the Framingham Heart Study显示文摘 | Levitzky YS Pencina M J Meigs JB | 2008 | JACC2008，51，3： | 1 |
| 19 | Vitamin D deficiency and risk of cardiovascular disease显示文摘 | Wang TJ Pencina M J Booth SL | | 0，，04： | 1 |
| 20 | A cost-mini- mization analysis of dexmedetomidine compared with midazolam for long-term sedation in the intensive care unit 显示文摘 | DASTA JF KANE-GILL SL PENCINA M | 2010 | Crit Care Med2010，38，2： | 1 |
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