5篇
您的检索式：作者名="PATRICK M. WOOD"
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| 1 | GDNF-Enhanced Axonal Regeneration and Myelination Following Spinal Cord Injury is Mediated by Primary Effects on Neurons显示文摘我们先前研究表明胶质细胞源性神经营养因子(GDNF)联合施万细胞移植能促进脊髓损伤后轴突再生和髓鞘形成。然而,GDNF介导这一过程的细胞靶点尚不清楚。在此,我们报道了GDNF可增加在体再生轴突的数目和直径,并促进体外背根神经节神经元的轴突向外生长,提示GDNF对神经元有直接作用。在施万细胞-背根神经节神经元共培养下,GDNF显著增加施万细胞生成的髓鞘数目;GDNF处理对孤立培养的施万细胞增殖无作用,但可促进已与神经轴突有突触联系的施万细胞增殖;GDNF可增加孤立施万细胞中分子量为140kDa的神经细胞黏附分子(NCAM)的表达,但对黏附分子L1表达或神经营养因子NGF、NT3及BDNF分泌没有影响。总之,这些结果支持假设:GDNF提高轴突再生和施万细胞髓鞘形成主要是通过GDNF对神经元的直接作用介导的,并且提示GDNF联合施万细胞移植可能是促进脊髓损伤后轴突再生和髓鞘形成的有效策略之一。 | LIQUN ZHANG ZHENGWEN MA GEORGE M. SMITH XUEJUN WEN YELENA PRESSMAN PATRICK M. WOOD AND XIAO-MING XU | 2009 | 神经损伤与功能重建2009，4，4： | 25 |
| 2 | A Systems Biology Approach for Studying Heterotopic Ossification: Proteomic Analysis of Clinical Serum and Tissue Samples显示文摘Heterotopic ossification(HO) refers to the abnormal formation of bone in soft tissue.Although some of the underlying processes of HO have been described, there are currently no clinical tests using validated biomarkers for predicting HO formation. As such, the diagnosis is made radiographically after HO has formed. To identify potential and novel biomarkers for HO, we used isobaric tags for relative and absolute quantitation(iTRAQ) and high-throughput antibody arrays to produce a semi-quantitative proteomics survey of serum and tissue from subjects with(HO^+) and without(HO^-) heterotopic ossification. The resulting data were then analyzed using a systems biology approach. We found that serum samples from subjects experiencing traumatic injuries with resulting HO have a different proteomic expression profile compared to those from the matched controls. Subsequent quantitative ELISA identified five blood serum proteins that were differentially regulated between the HO^+ and HO^- groups. Compared to HO^- samples, the amount of insulin-like growth factor I(IGF1) was up-regulated in HO^+ samples, whereas a lower amount of osteopontin(OPN), myeloperoxidase(MPO), runt-related transcription factor 2(RUNX2),and growth differentiation factor 2 or bone morphogenetic protein 9(BMP-9) was found in HO^+ samples(Welch two sample t-test; P < 0.05). These proteins, in combination with potential serum biomarkers previously reported, are key candidates for a serum diagnostic panel that may enable early detection of HO prior to radiographic and clinical manifestations. | Erin L. Crowgey Jennifer T. Wyffels Patrick M. Osborn Thomas T. Wood Laura E. Edsberg | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 1 |
| 3 | Consumption of a high-fat diet induces central insulin resistance independent of adiposity显示文摘 | Deborah J. Clegg Koro Gotoh Christopher Kemp Matthew D. Wortman Stephen C. Benoit Lynda M. Brown David D’Alessio Patrick Tso Randy J. Seeley Stephen C. Woods | 2011 | Physiology & Behavior2011，，1： | 1 |
| 4 | Listeria and Salmonella bacterial vectors of tumor-associated antigens for cancer immunotherapy显示文摘 | Yvonne Paterson Patrick D. Guirnalda Laurence M. Wood | 2010 | Seminars in Immunology2010，，3： | 1 |
| 5 | Cancer immunotherapy using Listeria monocytogenes and listerial virulence factors显示文摘 | Laurence M. Wood Patrick D. Guirnalda Matthew M. Seavey Yvonne Paterson | 2008 | Immunologic Research . 2008 (1-3)2008，，1： | 1 |
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