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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Understanding and forecasting tropical cyclone intensity change with the typhoon intensity prediction scheme(TIPS)显示文摘 | PATRICK J F | 1997 | Weather and Forecasting1997，12，4： | 1 |
| 3 | Determinants of early alcohol use in healthy adolescents: The differential contribution of neuroimaging and psychological factors 显示文摘 | NEES F TZSCHOPPE J PATRICK C J | 2011 | Neuropsychopharmacology2011，36，23： | 1 |
| 4 | Isolation and characterization of serum immunoglobulin classes of the ostrich (Struthio camdus) 显示文摘 | Hilary F Cadman Patrick J Kelly Mildred Dikanifura | 1994 | Avian Diseases1994，38，： | 1 |
| 5 | Kinetic separation of hexane isomers by fixed-bed adsorption with a microporous metal-organic framework显示文摘 | PATRICK S B ZAPATA F SILVA J A C | 2007 | J Phys Chem B2007，111，22： | 1 |
| 6 | Image understanding for iris biometrics:a survey 显示文摘 | Kevin W B Karen H Patrick J F | 2008 | Computer Vision and Image Understanding2008，110，2： | 1 |
| 7 | The development of the nucleus freedom cochlear implant system显示文摘 | James F Patrick Peter A Busby Peter J Gibson | 2006 | Trends in Amplification2006，10，4： | 1 |
| 8 | Analysis of the response of long period fiber gratings to external index of refraction 显示文摘 | Patrick H J Kersey A D Buchaltz F | 1998 | J Lightwave Technol 11998，16，9： | 1 |
| 9 | Modeling low reynolds number incompressible flows using SPH显示文摘 | Morris J P Patrick J F Zhu Yi | 1997 | Journal of ComputationalPhysics1997，136，： | 1 |
| 10 | Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial显示文摘 | Edward J Gane Stuart K Roberts Catherine AM Stedman Peter W Angus Brett Ritchie Rob Elston David Ipe Peter N Morcos Linda Baher Isabel Najera Tom Chu Uri Lopatin M Michelle Berrey William Bradford Mark Laughlin Nancy S Shulman Patrick F Smith | 2010 | The Lancet2010，，9751： | 1 |
| 11 | Modeling Low Reynolds Number Incompressible Flows Using SPH显示文摘 | Joseph P M Patrick J F Yi Zhu | 1997 | Journal of Computational Physics1997，，136： | 1 |
| 12 | Oxidation of Roading Asphalts 显示文摘 | Herrington P R Patrick J E Ball G F A | 1994 | IndEngChemRes1994，33，11： | 1 |
| 13 | Osteocalcin : Diagnostic meth- ods and clinical appl!cations显示文摘 | MICHAEL J P PATRICK F F | 1991 | Crit Rev Clin Lab Sci1991，28，4： | 1 |
| 14 | Metabolic engineering of sugars and simple sugar derivatives in plants显示文摘 | Patrick J W Botha F C Birch R G | 2013 | Plant Biotechnology Journal2013，11，2： | 1 |
| 15 | 显示文摘 | Michael J Daniel E Patrick F | 2005 | Clin Pulm Med2005，12，： | 1 |
| 16 | Modeling low Reynolds number incompressible flows using SPH显示文摘 | JOSEPH P M PATRICK J F ZHU Y | 1997 | J Computational Physics1997，136，： | 1 |
| 17 | The Nucleus 22-channel cochlear implant system显示文摘 | Patrick J F Clark G M | 1991 | Ear Hear1991，12，4： | 1 |
| 18 | Multiple independent emer- gences of type 2 vaccine-derived polioviruses during a large outbreak in northern Nigeria显示文摘 | Burns C C Shaw J Jorba J Bukbuk D Adu F Gumede N Pate M A Abanida E A Gasasira A Iber J Chen Q Vincent A Chenoweth P Henderson E Wannemuehler K Naeem A Umarni R N Nishimura Y Shimizu H Baba M Adeniji A Williams A J Kil- patrick D R Oberste M S Wassilak S G Tomori O Pallansch M A Kew O | 2013 | J Virol2013，87，9： | 1 |
| 19 | Dynamics of soll microbial biomass C and soil fertility in cropland mulched with plastic film in a semiarid ago-ecosystem 显示文摘 | LI F M SONG Q H PATRICK K J | 2004 | Soil Biol Biochem2004，36，： | 1 |
| 20 | Oxidation of roading asphalt显示文摘 | Herrington P R Patrick J E George F A B | 1994 | Ind Eng Chem Res1994，33，11： | 1 |
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