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| 1 | Current knowledge on diabetic retinopathy from human donor tissues显示文摘According to the American Diabetes Association,diabetes was the seventh leading cause of death,and diabetic retinopathy the leading cause of blindness in working age adults in the United States in 2010.Diabetes is characterized by hyperglycemia associated with either hypoinsulinemia or insulin resistance,and over time,this chronic metabolic condition may lead to various complications including kidney failure,heart attacks,and retinal degeneration.In order to better understand the molecular basis of this disease and its complications,animal models have been the primary approach used to investigate the effects of diabetes on various tissues or cell types of the body,including the retina.However,inherent to these animal models are critical limitations that make the insight gained from these models challenging to apply to the human pathology.These difficulties in translating the knowledge obtained from animal studies have led a growing number of research groups to explore the diabetes complications,especially diabetic retinopathy,on tissues from human donors.This review summarizes the data collected from diabetic patients at various stages of diabetic retinopathy and classifies the data based upon their relevance to the main aspects of diabetic retinopathy:retinal vasculature dysfunction,inflammation,and neurodegeneration.This review discusses the importance of those studies to discriminate and establish the relevance of the findings obtained from animal models but also the limitations of such approaches. | Jessica H Eisma Jennifer E Dulle Patrice E Fort | 2015 | World Journal of Diabetes2015，6，2： | 19 |
| 2 | Metastasized pancreatic carcinoma with neoadjuvant FOLFIRINOX therapy and R0 resection显示文摘Patients with metastasized carcinoma of the pancreas have a very poor prognosis, and long-term survival cannot be expected. This case report describes two patients with an initial diagnosis of metastatic pancreatic cancer, both with hepatic metastases and one with an additional peritoneal carcinomatosis. Initially, both patients were treated intravenously with the FOLFIRINOX chemotherapy regimen, consisting of 5-FU, folinic acid, irinotecan and oxaliplatin. Surprisingly, the FOLFIRINOX treatment resulted in complete resolution of the hepatic metastases in both patients, with no lesions detectable by computed tomography scan. Furthermore, treatment response included decreased diameter of the primary tumor in the tail of the pancreas and disappearance of the additional peritoneal carcinomatosis. Both patients were discussed by our multidisciplinary tumor board, which recommended surgical resections of the carcinoma. The R0 resection of the primary tumor was successful in both cases and, interestingly, the resected tissues showed no evidence of the hepatic metastases intraoperatively. In the first case, the patient received a postoperative 6-mo course of adjuvant chemotherapy with gemcitabine. In the second case, the patient continued to receive the FOLFIRINOX regimen for an additional 6 mo postoperatively. At 12 mo after the operation, a nonresectable retroperitoneal lymph node metastasis was detected in the first patient, whereas the second patient remained in complete remission at the time of this report(5 mo after the adjuvant therapy was discontinued). This case report is the first of its kind to describe two cases of hepatic metastatic pancreatic carcinoma that were resectable following treatment with FOLFIRINOX. Further studies are required to examine the role of FOLFIRINOX as a neoadjuvant treatment option in subgroups of patients with initially metastasized pancreatic carcinoma. | Sophie Schneitler Patric Krpil Jasmin Riemer Gerald Antoch Wolfram Trudo Knoefel Dieter Hussinger Dirk Graf | 2015 | World Journal of Gastroenterology2015，21，20： | 9 |
| 3 | Characterization of the caprine stearoyl-CoA desaturase gene and its mRNA showing an unusually long 3′-UTR sequence arising from a single exon显示文摘 | Laurence Bernard Christine Leroux Hélène Hayes Mathieu Gautier Yves Chilliard Patrice Martin | 2001 | Gene2001，，1： | 2 |
| 4 | Soil water absorption by mountain and piedmont显示文摘 | Patric J H | 1965 | Forests Soil Science of America Proceedings1965，29，： | 1 |
| 5 | Soil water absorption by mountain and piedmont显示文摘 | Patric J H | 1965 | Forests Soil Science of America Proceedings1965，29，： | 1 |
| 6 | Long-period fiber gratings for structural bend sensing 显示文摘 | Patric H J Chang C C Vohra S T | 1998 | Electron Lett1998，34，18： | 1 |
| 7 | Real user costs and the demand for sin-gle family housing显示文摘 | Hendershott Patric H | 1980 | Brookings Papers on Economic Activity1980，，2： | 1 |
| 8 | Canopy and Litter Interception of Rain- fall by Hardwoods of Eastern United States显示文摘 | Helvey J D J H Patric | 1965 | Water Re- sources Research1965，1，： | 1 |
| 9 | Euro- pean brown hare syndrome virus: molecular cloning and se- quencing of the genome显示文摘 | GHISLAINE L G STEPHANIE H PATRICE V | 1996 | J Gen Virol1996，77，8： | 1 |
| 10 | Hapten synthesis for a monoclonal antibody based ELISA for deltamethrin 显示文摘 | Patrice N Jean-Pierre H | 1998 | J Agric and Food Chemistry1998，46，： | 1 |
| 11 | Regional atmospheric deposition patterns of Ag, As,Bi,Cd,Hg,Mo,Sb and TI in a 188 000 kmZarea in the European Arctic as displayed by terrestrial moss samples-Long-range atmospheric transport vs local im- pact 显示文摘 | Reimann Clemens De Caritat Patrice Halleraker Jo H | 1997 | Atmospheric Environment1997，3，23： | 1 |
| 12 | Spinal cord monitoring in scoliosis surgery using an epidural electrode:results of a prospective,consecutive series of 191 cases显示文摘 | Franck A Patrice H Jerome SG | 2006 | Spine2006，51，22： | 1 |
| 13 | Structural characterization of bis(L-Met) 显示文摘 | Roxy B W Patrice de M Derek J H | 1977 | Inorg Chem1977，16，6： | 1 |
| 14 | Ultrafine particulate matter and high-level benzene urban air pollution in relation to oxidative DNA damage 显示文摘 | Avogbe Patrice H Ayi-Fanou | 2005 | Carcinogenesis2005，26，3： | 1 |
| 15 | Soil water absorption by mountain and piedmont forests显示文摘 | Patric J H Douglass J E Hewlett J D | 1965 | Soil Science Society of America Journal1965，29，3： | 1 |
| 16 | Soil water absorption by mountain and piedmont 显示文摘 | Patric J H Helvey J D | 1965 | Forests Soil Science of America proceedings1965，29，： | 1 |
| 17 | Canopy and litter interception of rainfall by hardwoods of eastern United States显示文摘 | HELVEY J D PATRIC J H | 1965 | Water Resour Res1965，1，2： | 1 |
| 18 | Reinforcing mechanisms of starch nanocrystals in a nonvulcanized natural rubber matrix显示文摘 | PATRICE M(E)L(E) H(E)L(E)NE ANGELLIER-COUSSY SONIA MOLINA-BOISSEAU | | 0，，05： | 1 |
| 19 | Care Groups:A Model to Mentor Novice Nursing Students显示文摘 | Richard L Pullen Jr Patrice H | 2001 | Nurse Educ2001，26，6： | 1 |
| 20 | Multimodal Treatment of Hepatocellular Carcinoma显示文摘 | Dirk Graf Daniel Vallb?hmer Wolfram Trudo Knoefel Patric Kr?pil Gerald Antoch Abdurrahaman Sagir Dieter H?ussinger | 2014 | European Journal of Internal Medicine2014，，： | 1 |
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